KR195_HUMAN
ID KR195_HUMAN Reviewed; 72 AA.
AC Q3LI72; A4IF22;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Keratin-associated protein 19-5;
GN Name=KRTAP19-5; Synonyms=KAP19.5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair root;
RA Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT "Identification of complete keratin-associated protein (KAP) gene cluster
RT spanning 800 kb region on human chromosome 21q22.11.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q3LI72; Q8IWG5: ANKHD1; NbExp=3; IntAct=EBI-1048945, EBI-355540;
CC Q3LI72; P41238: APOBEC1; NbExp=3; IntAct=EBI-1048945, EBI-12819523;
CC Q3LI72; Q03989: ARID5A; NbExp=3; IntAct=EBI-1048945, EBI-948603;
CC Q3LI72; Q86V38: ATN1; NbExp=6; IntAct=EBI-1048945, EBI-11954292;
CC Q3LI72; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-1048945, EBI-1166928;
CC Q3LI72; O14503: BHLHE40; NbExp=3; IntAct=EBI-1048945, EBI-711810;
CC Q3LI72; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-1048945, EBI-1383687;
CC Q3LI72; Q13554: CAMK2B; NbExp=3; IntAct=EBI-1048945, EBI-1058722;
CC Q3LI72; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-1048945, EBI-744545;
CC Q3LI72; Q96LX7-5: CCDC17; NbExp=3; IntAct=EBI-1048945, EBI-12165781;
CC Q3LI72; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-1048945, EBI-12139335;
CC Q3LI72; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-1048945, EBI-947551;
CC Q3LI72; P27658: COL8A1; NbExp=3; IntAct=EBI-1048945, EBI-747133;
CC Q3LI72; Q9BSW2: CRACR2A; NbExp=3; IntAct=EBI-1048945, EBI-739773;
CC Q3LI72; Q02930-3: CREB5; NbExp=3; IntAct=EBI-1048945, EBI-10192698;
CC Q3LI72; P02489: CRYAA; NbExp=3; IntAct=EBI-1048945, EBI-6875961;
CC Q3LI72; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-1048945, EBI-3867333;
CC Q3LI72; O75553: DAB1; NbExp=3; IntAct=EBI-1048945, EBI-7875264;
CC Q3LI72; Q15038: DAZAP2; NbExp=11; IntAct=EBI-1048945, EBI-724310;
CC Q3LI72; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-1048945, EBI-9679045;
CC Q3LI72; Q96MA1: DMRTB1; NbExp=3; IntAct=EBI-1048945, EBI-954466;
CC Q3LI72; P50570-2: DNM2; NbExp=3; IntAct=EBI-1048945, EBI-10968534;
CC Q3LI72; O95967: EFEMP2; NbExp=3; IntAct=EBI-1048945, EBI-743414;
CC Q3LI72; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-1048945, EBI-744099;
CC Q3LI72; Q6NXG1: ESRP1; NbExp=3; IntAct=EBI-1048945, EBI-10213520;
CC Q3LI72; Q03828: EVX2; NbExp=3; IntAct=EBI-1048945, EBI-17280301;
CC Q3LI72; Q92567-2: FAM168A; NbExp=3; IntAct=EBI-1048945, EBI-11978259;
CC Q3LI72; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-1048945, EBI-745689;
CC Q3LI72; P22607: FGFR3; NbExp=3; IntAct=EBI-1048945, EBI-348399;
CC Q3LI72; P01100: FOS; NbExp=3; IntAct=EBI-1048945, EBI-852851;
CC Q3LI72; Q9BZE0: GLIS2; NbExp=5; IntAct=EBI-1048945, EBI-7251368;
CC Q3LI72; Q8IVS8: GLYCTK; NbExp=3; IntAct=EBI-1048945, EBI-748515;
CC Q3LI72; O95872: GPANK1; NbExp=3; IntAct=EBI-1048945, EBI-751540;
CC Q3LI72; P62993: GRB2; NbExp=3; IntAct=EBI-1048945, EBI-401755;
CC Q3LI72; Q7Z429: GRINA; NbExp=3; IntAct=EBI-1048945, EBI-2832909;
CC Q3LI72; P06396: GSN; NbExp=3; IntAct=EBI-1048945, EBI-351506;
CC Q3LI72; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-1048945, EBI-11978177;
CC Q3LI72; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-1048945, EBI-11956675;
CC Q3LI72; A0A024R5S0: hCG_2003792; NbExp=3; IntAct=EBI-1048945, EBI-10188461;
CC Q3LI72; V9HW27: HEL-S-101; NbExp=3; IntAct=EBI-1048945, EBI-10178933;
CC Q3LI72; O14964: HGS; NbExp=3; IntAct=EBI-1048945, EBI-740220;
CC Q3LI72; P17482: HOXB9; NbExp=3; IntAct=EBI-1048945, EBI-745290;
CC Q3LI72; Q0VD86: INCA1; NbExp=5; IntAct=EBI-1048945, EBI-6509505;
CC Q3LI72; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-1048945, EBI-14069005;
CC Q3LI72; Q92876: KLK6; NbExp=3; IntAct=EBI-1048945, EBI-2432309;
CC Q3LI72; Q5T749: KPRP; NbExp=3; IntAct=EBI-1048945, EBI-10981970;
CC Q3LI72; O76011: KRT34; NbExp=3; IntAct=EBI-1048945, EBI-1047093;
CC Q3LI72; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-1048945, EBI-10176396;
CC Q3LI72; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-1048945, EBI-11992140;
CC Q3LI72; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-1048945, EBI-11962084;
CC Q3LI72; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-1048945, EBI-10261141;
CC Q3LI72; Q9Y5V3: MAGED1; NbExp=9; IntAct=EBI-1048945, EBI-716006;
CC Q3LI72; Q8NDC0: MAPK1IP1L; NbExp=3; IntAct=EBI-1048945, EBI-741424;
CC Q3LI72; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-1048945, EBI-5662487;
CC Q3LI72; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-1048945, EBI-2858213;
CC Q3LI72; O43482: OIP5; NbExp=3; IntAct=EBI-1048945, EBI-536879;
CC Q3LI72; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-1048945, EBI-10225049;
CC Q3LI72; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-1048945, EBI-12813389;
CC Q3LI72; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-1048945, EBI-10181968;
CC Q3LI72; Q9HBE1-4: PATZ1; NbExp=5; IntAct=EBI-1048945, EBI-11022007;
CC Q3LI72; P78337: PITX1; NbExp=3; IntAct=EBI-1048945, EBI-748265;
CC Q3LI72; Q99697-2: PITX2; NbExp=3; IntAct=EBI-1048945, EBI-12138495;
CC Q3LI72; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-1048945, EBI-769257;
CC Q3LI72; Q16633: POU2AF1; NbExp=3; IntAct=EBI-1048945, EBI-943588;
CC Q3LI72; Q96I34: PPP1R16A; NbExp=3; IntAct=EBI-1048945, EBI-710402;
CC Q3LI72; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-1048945, EBI-12000762;
CC Q3LI72; Q9UGI9: PRKAG3; NbExp=3; IntAct=EBI-1048945, EBI-7428853;
CC Q3LI72; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-1048945, EBI-1567797;
CC Q3LI72; Q9NZ81: PRR13; NbExp=5; IntAct=EBI-1048945, EBI-740924;
CC Q3LI72; P86480: PRR20D; NbExp=3; IntAct=EBI-1048945, EBI-12754095;
CC Q3LI72; P25788: PSMA3; NbExp=3; IntAct=EBI-1048945, EBI-348380;
CC Q3LI72; P49721: PSMB2; NbExp=3; IntAct=EBI-1048945, EBI-359335;
CC Q3LI72; P28070: PSMB4; NbExp=3; IntAct=EBI-1048945, EBI-603350;
CC Q3LI72; Q93062: RBPMS; NbExp=4; IntAct=EBI-1048945, EBI-740322;
CC Q3LI72; Q93062-3: RBPMS; NbExp=6; IntAct=EBI-1048945, EBI-740343;
CC Q3LI72; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-1048945, EBI-11987469;
CC Q3LI72; Q9BQY4: RHOXF2; NbExp=6; IntAct=EBI-1048945, EBI-372094;
CC Q3LI72; Q9H0F5: RNF38; NbExp=3; IntAct=EBI-1048945, EBI-2341200;
CC Q3LI72; Q7L0R7: RNF44; NbExp=3; IntAct=EBI-1048945, EBI-2845060;
CC Q3LI72; Q14D33: RTP5; NbExp=3; IntAct=EBI-1048945, EBI-10217913;
CC Q3LI72; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-1048945, EBI-6257312;
CC Q3LI72; Q13214-2: SEMA3B; NbExp=3; IntAct=EBI-1048945, EBI-11017428;
CC Q3LI72; Q16637: SMN2; NbExp=3; IntAct=EBI-1048945, EBI-395421;
CC Q3LI72; Q8NCR6: SMRP1; NbExp=3; IntAct=EBI-1048945, EBI-10269322;
CC Q3LI72; P09234: SNRPC; NbExp=3; IntAct=EBI-1048945, EBI-766589;
CC Q3LI72; Q5JUK2: SOHLH1; NbExp=3; IntAct=EBI-1048945, EBI-12288855;
CC Q3LI72; Q9NQB0-10: TCF7L2; NbExp=3; IntAct=EBI-1048945, EBI-11746252;
CC Q3LI72; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-1048945, EBI-8644516;
CC Q3LI72; Q96LM6: TEX37; NbExp=3; IntAct=EBI-1048945, EBI-743976;
CC Q3LI72; Q08117-2: TLE5; NbExp=3; IntAct=EBI-1048945, EBI-11741437;
CC Q3LI72; Q15025: TNIP1; NbExp=3; IntAct=EBI-1048945, EBI-357849;
CC Q3LI72; Q8N831: TSPYL6; NbExp=3; IntAct=EBI-1048945, EBI-12023322;
CC Q3LI72; Q9UHD9: UBQLN2; NbExp=3; IntAct=EBI-1048945, EBI-947187;
CC Q3LI72; Q08AM6: VAC14; NbExp=6; IntAct=EBI-1048945, EBI-2107455;
CC Q3LI72; Q14119: VEZF1; NbExp=3; IntAct=EBI-1048945, EBI-11980193;
CC Q3LI72; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-1048945, EBI-2559305;
CC Q3LI72; A0A0C4DGF1: ZBTB32; NbExp=5; IntAct=EBI-1048945, EBI-10188476;
CC Q3LI72; Q15915: ZIC1; NbExp=3; IntAct=EBI-1048945, EBI-11963196;
CC Q3LI72; Q96IQ9: ZNF414; NbExp=5; IntAct=EBI-1048945, EBI-744257;
CC -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
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DR EMBL; AB096946; BAE46361.1; -; mRNA.
DR EMBL; BC100836; AAI00837.1; -; mRNA.
DR EMBL; BC100837; AAI00838.1; -; mRNA.
DR EMBL; BC100838; AAI00839.1; -; mRNA.
DR EMBL; BC100839; AAI00840.1; -; mRNA.
DR EMBL; BC113020; AAI13021.1; -; mRNA.
DR EMBL; BC113021; AAI13022.1; -; mRNA.
DR CCDS; CCDS13597.1; -.
DR RefSeq; NP_853642.1; NM_181611.1.
DR AlphaFoldDB; Q3LI72; -.
DR BioGRID; 130655; 103.
DR IntAct; Q3LI72; 98.
DR STRING; 9606.ENSP00000334985; -.
DR iPTMnet; Q3LI72; -.
DR PhosphoSitePlus; Q3LI72; -.
DR BioMuta; KRTAP19-5; -.
DR DMDM; 88909171; -.
DR MassIVE; Q3LI72; -.
DR PaxDb; Q3LI72; -.
DR PeptideAtlas; Q3LI72; -.
DR PRIDE; Q3LI72; -.
DR ProteomicsDB; 61770; -.
DR Antibodypedia; 76478; 28 antibodies from 5 providers.
DR DNASU; 337972; -.
DR Ensembl; ENST00000334151.3; ENSP00000334985.2; ENSG00000186977.3.
DR GeneID; 337972; -.
DR KEGG; hsa:337972; -.
DR MANE-Select; ENST00000334151.3; ENSP00000334985.2; NM_181611.3; NP_853642.1.
DR UCSC; uc011ada.3; human.
DR CTD; 337972; -.
DR GeneCards; KRTAP19-5; -.
DR HGNC; HGNC:18940; KRTAP19-5.
DR HPA; ENSG00000186977; Tissue enriched (skin).
DR neXtProt; NX_Q3LI72; -.
DR PharmGKB; PA134992782; -.
DR VEuPathDB; HostDB:ENSG00000186977; -.
DR eggNOG; ENOG502TDP7; Eukaryota.
DR GeneTree; ENSGT00940000165160; -.
DR HOGENOM; CLU_184630_0_0_1; -.
DR OMA; KSHAGCQ; -.
DR PathwayCommons; Q3LI72; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q3LI72; -.
DR BioGRID-ORCS; 337972; 5 hits in 1020 CRISPR screens.
DR GenomeRNAi; 337972; -.
DR Pharos; Q3LI72; Tdark.
DR PRO; PR:Q3LI72; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q3LI72; protein.
DR Bgee; ENSG00000186977; Expressed in sural nerve and 31 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR Pfam; PF11759; KRTAP; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..72
FT /note="Keratin-associated protein 19-5"
FT /id="PRO_0000223907"
SQ SEQUENCE 72 AA; 7624 MW; EEBDA9D9506BCCD7 CRC64;
MNYYGNYYGG LGYGYGGFDD LGYGYGCGCG SFRRLGYGGG YGGYGYGSGF GGYGYRSCRP
SCYGGYGFSG FY
