ID   KR195_MOUSE             Reviewed;          62 AA.
AC   O08632;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Keratin-associated protein 19-5;
DE   AltName: Full=Glycine tyrosine-rich hair protein {ECO:0000312|EMBL:BAA19683.1};
DE   AltName: Full=High-glycine tyrosine keratin type 1 alpha {ECO:0000303|PubMed:9374545};
DE            Short=HGTp type 1 alpha {ECO:0000303|PubMed:9374545};
DE   AltName: Full=Keratin-associated protein 8-2;
GN   Name=Krtap19-5; Synonyms=Krtap8-2;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAA19683.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Skin {ECO:0000312|EMBL:BAA19683.1};
RX   PubMed=9374545; DOI=10.1074/jbc.272.48.30512;
RA   Aoki N., Ito K., Ito M.;
RT   "Isolation and characterization of mouse high-glycine/tyrosine proteins.";
RL   J. Biol. Chem. 272:30512-30518(1997).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins. {ECO:0000305}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in skin during two hair growth cycles.
CC       Expression restricted to the cortical cells of hair follicles,
CC       appearing first in the cortical cells processing the flat nuclei
CC       located a few cells above the dermal papilla.
CC       {ECO:0000269|PubMed:9374545}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; D86422; BAA19683.1; -; mRNA.
DR   CCDS; CCDS37388.1; -.
DR   RefSeq; NP_034806.2; NM_010676.2.
DR   AlphaFoldDB; O08632; -.
DR   STRING; 10090.ENSMUSP00000055511; -.
DR   MaxQB; O08632; -.
DR   PaxDb; O08632; -.
DR   PRIDE; O08632; -.
DR   ProteomicsDB; 263675; -.
DR   DNASU; 16704; -.
DR   GeneID; 16704; -.
DR   KEGG; mmu:16704; -.
DR   CTD; 337972; -.
DR   MGI; MGI:1330295; Krtap19-5.
DR   eggNOG; ENOG502TDP7; Eukaryota.
DR   Reactome; R-MMU-6805567; Keratinization.
DR   BioGRID-ORCS; 16704; 1 hit in 71 CRISPR screens.
DR   PRO; PR:O08632; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; O08632; protein.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR   Pfam; PF11759; KRTAP; 1.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..62
FT                   /note="Keratin-associated protein 19-5"
FT                   /id="PRO_0000361663"
FT   REGION          5..56
FT                   /note="14 X 2 AA repeats of G-[YCGS]"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   62 AA;  6688 MW;  493A2EB2B0C219A5 CRC64;
     MSYYGSYYGG LGSGIRGFGN LGYGYGCGCG FGGYGYGSGY GRYGYGYPRP LYYGGYGFSR
     FY