KR196_HUMAN
ID KR196_HUMAN Reviewed; 58 AA.
AC Q3LI70; Q3LI71;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Keratin-associated protein 19-6;
GN Name=KRTAP19-6; Synonyms=KAP19.6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair root;
RA Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT "Identification of complete keratin-associated protein (KAP) gene cluster
RT spanning 800 kb region on human chromosome 21q22.11.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q3LI70; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-12805508, EBI-1166928;
CC Q3LI70; O75934: BCAS2; NbExp=3; IntAct=EBI-12805508, EBI-1050106;
CC Q3LI70; Q9H1P6: C20orf85; NbExp=3; IntAct=EBI-12805508, EBI-12155483;
CC Q3LI70; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-12805508, EBI-744545;
CC Q3LI70; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-12805508, EBI-1104933;
CC Q3LI70; O75909-2: CCNK; NbExp=3; IntAct=EBI-12805508, EBI-12010594;
CC Q3LI70; Q8TCT0: CERK; NbExp=3; IntAct=EBI-12805508, EBI-10274247;
CC Q3LI70; Q02930-3: CREB5; NbExp=3; IntAct=EBI-12805508, EBI-10192698;
CC Q3LI70; Q49AN0: CRY2; NbExp=3; IntAct=EBI-12805508, EBI-2212355;
CC Q3LI70; A8MUP2: CSKMT; NbExp=3; IntAct=EBI-12805508, EBI-12842046;
CC Q3LI70; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-12805508, EBI-3867333;
CC Q3LI70; Q96MA1: DMRTB1; NbExp=3; IntAct=EBI-12805508, EBI-954466;
CC Q3LI70; Q86UW9: DTX2; NbExp=3; IntAct=EBI-12805508, EBI-740376;
CC Q3LI70; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-12805508, EBI-744099;
CC Q3LI70; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-12805508, EBI-745689;
CC Q3LI70; Q9NW38: FANCL; NbExp=3; IntAct=EBI-12805508, EBI-2339898;
CC Q3LI70; Q9BVV2: FNDC11; NbExp=3; IntAct=EBI-12805508, EBI-744935;
CC Q3LI70; O75593: FOXH1; NbExp=3; IntAct=EBI-12805508, EBI-1759806;
CC Q3LI70; O95872: GPANK1; NbExp=3; IntAct=EBI-12805508, EBI-751540;
CC Q3LI70; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-12805508, EBI-11978177;
CC Q3LI70; P49639: HOXA1; NbExp=3; IntAct=EBI-12805508, EBI-740785;
CC Q3LI70; Q9ULV5-2: HSF4; NbExp=3; IntAct=EBI-12805508, EBI-12056251;
CC Q3LI70; Q0VD86: INCA1; NbExp=3; IntAct=EBI-12805508, EBI-6509505;
CC Q3LI70; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-12805508, EBI-14069005;
CC Q3LI70; Q5T749: KPRP; NbExp=3; IntAct=EBI-12805508, EBI-10981970;
CC Q3LI70; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-12805508, EBI-10176396;
CC Q3LI70; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-12805508, EBI-3957672;
CC Q3LI70; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-12805508, EBI-1043191;
CC Q3LI70; Q14847-2: LASP1; NbExp=3; IntAct=EBI-12805508, EBI-9088686;
CC Q3LI70; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-12805508, EBI-2341787;
CC Q3LI70; O14770-4: MEIS2; NbExp=3; IntAct=EBI-12805508, EBI-8025850;
CC Q3LI70; Q13064: MKRN3; NbExp=3; IntAct=EBI-12805508, EBI-2340269;
CC Q3LI70; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-12805508, EBI-5662487;
CC Q3LI70; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-12805508, EBI-2858213;
CC Q3LI70; Q9BVI4: NOC4L; NbExp=3; IntAct=EBI-12805508, EBI-395927;
CC Q3LI70; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12805508, EBI-741158;
CC Q3LI70; O43482: OIP5; NbExp=3; IntAct=EBI-12805508, EBI-536879;
CC Q3LI70; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-12805508, EBI-11022007;
CC Q3LI70; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-12805508, EBI-12014286;
CC Q3LI70; Q9NRY6: PLSCR3; NbExp=3; IntAct=EBI-12805508, EBI-750734;
CC Q3LI70; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-12805508, EBI-769257;
CC Q3LI70; Q12837: POU4F2; NbExp=3; IntAct=EBI-12805508, EBI-17236143;
CC Q3LI70; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-12805508, EBI-12000762;
CC Q3LI70; O75360: PROP1; NbExp=3; IntAct=EBI-12805508, EBI-9027467;
CC Q3LI70; P49721: PSMB2; NbExp=3; IntAct=EBI-12805508, EBI-359335;
CC Q3LI70; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-12805508, EBI-11987469;
CC Q3LI70; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-12805508, EBI-372094;
CC Q3LI70; Q06455-2: RUNX1T1; NbExp=3; IntAct=EBI-12805508, EBI-11984663;
CC Q3LI70; Q9H1K4: SLC25A18; NbExp=3; IntAct=EBI-12805508, EBI-6269587;
CC Q3LI70; Q16637: SMN2; NbExp=3; IntAct=EBI-12805508, EBI-395421;
CC Q3LI70; Q8NCR6: SMRP1; NbExp=3; IntAct=EBI-12805508, EBI-10269322;
CC Q3LI70; P14678-2: SNRPB; NbExp=3; IntAct=EBI-12805508, EBI-372475;
CC Q3LI70; P09234: SNRPC; NbExp=3; IntAct=EBI-12805508, EBI-766589;
CC Q3LI70; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-12805508, EBI-11959123;
CC Q3LI70; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-12805508, EBI-750487;
CC Q3LI70; Q96M29: TEKT5; NbExp=3; IntAct=EBI-12805508, EBI-10239812;
CC Q3LI70; Q96A09: TENT5B; NbExp=3; IntAct=EBI-12805508, EBI-752030;
CC Q3LI70; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-12805508, EBI-11952651;
CC Q3LI70; Q8N831: TSPYL6; NbExp=3; IntAct=EBI-12805508, EBI-12023322;
CC Q3LI70; O95231: VENTX; NbExp=3; IntAct=EBI-12805508, EBI-10191303;
CC Q3LI70; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-12805508, EBI-11957216;
CC Q3LI70; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-12805508, EBI-2559305;
CC Q3LI70; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-12805508, EBI-744257;
CC Q3LI70; Q96EJ4; NbExp=3; IntAct=EBI-12805508, EBI-750454;
CC -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE46363.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AB096947; BAE46362.1; -; mRNA.
DR EMBL; AB096948; BAE46363.1; ALT_FRAME; mRNA.
DR EMBL; AP000567; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS13598.1; -.
DR RefSeq; NP_001290049.1; NM_001303120.1.
DR RefSeq; NP_853643.1; NM_181612.3.
DR AlphaFoldDB; Q3LI70; -.
DR BioGRID; 130656; 85.
DR IntAct; Q3LI70; 64.
DR STRING; 9606.ENSP00000375107; -.
DR BioMuta; KRTAP19-6; -.
DR DMDM; 215274009; -.
DR PaxDb; Q3LI70; -.
DR PRIDE; Q3LI70; -.
DR TopDownProteomics; Q3LI70; -.
DR DNASU; 337973; -.
DR Ensembl; ENST00000334046.5; ENSP00000375107.3; ENSG00000186925.6.
DR GeneID; 337973; -.
DR KEGG; hsa:337973; -.
DR MANE-Select; ENST00000334046.5; ENSP00000375107.3; NM_181612.3; NP_853643.1.
DR UCSC; uc002yok.2; human.
DR CTD; 337973; -.
DR GeneCards; KRTAP19-6; -.
DR HGNC; HGNC:18941; KRTAP19-6.
DR HPA; ENSG00000186925; Not detected.
DR neXtProt; NX_Q3LI70; -.
DR PharmGKB; PA134901069; -.
DR VEuPathDB; HostDB:ENSG00000186925; -.
DR eggNOG; ENOG502TEB6; Eukaryota.
DR GeneTree; ENSGT00950000184153; -.
DR HOGENOM; CLU_184630_0_0_1; -.
DR OMA; CHPSCHE; -.
DR PathwayCommons; Q3LI70; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q3LI70; -.
DR BioGRID-ORCS; 337973; 95 hits in 986 CRISPR screens.
DR GenomeRNAi; 337973; -.
DR Pharos; Q3LI70; Tdark.
DR PRO; PR:Q3LI70; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q3LI70; protein.
DR Bgee; ENSG00000186925; Expressed in cell and 17 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR Pfam; PF11759; KRTAP; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..58
FT /note="Keratin-associated protein 19-6"
FT /id="PRO_0000223908"
SQ SEQUENCE 58 AA; 6267 MW; 99560DB898B6BDD0 CRC64;
MRYYGSYYRG LGYGCGGFGG LGYGCGCGGY RYGSGYGGYR YGCCRPSCRE GYGFSGFY
