KR197_HUMAN
ID KR197_HUMAN Reviewed; 63 AA.
AC Q3SYF9; Q08EP7;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Keratin-associated protein 19-7;
GN Name=KRTAP19-7; Synonyms=KAP19.7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair root;
RA Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT "Identification of complete keratin-associated protein (KAP) gene cluster
RT spanning 800 kb region on human chromosome 21q22.11.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q3SYF9; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-10241353, EBI-11954519;
CC Q3SYF9; Q03989: ARID5A; NbExp=3; IntAct=EBI-10241353, EBI-948603;
CC Q3SYF9; Q9H6L4: ARMC7; NbExp=3; IntAct=EBI-10241353, EBI-742909;
CC Q3SYF9; Q86V38: ATN1; NbExp=3; IntAct=EBI-10241353, EBI-11954292;
CC Q3SYF9; Q8N5M1: ATPAF2; NbExp=3; IntAct=EBI-10241353, EBI-1166928;
CC Q3SYF9; P0C7T5: ATXN1L; NbExp=3; IntAct=EBI-10241353, EBI-8624731;
CC Q3SYF9; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-10241353, EBI-742750;
CC Q3SYF9; O14503: BHLHE40; NbExp=3; IntAct=EBI-10241353, EBI-711810;
CC Q3SYF9; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-10241353, EBI-1383687;
CC Q3SYF9; Q13554: CAMK2B; NbExp=3; IntAct=EBI-10241353, EBI-1058722;
CC Q3SYF9; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-10241353, EBI-744545;
CC Q3SYF9; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-10241353, EBI-1104933;
CC Q3SYF9; O75909-2: CCNK; NbExp=3; IntAct=EBI-10241353, EBI-12010594;
CC Q3SYF9; P27658: COL8A1; NbExp=3; IntAct=EBI-10241353, EBI-747133;
CC Q3SYF9; P02489: CRYAA; NbExp=3; IntAct=EBI-10241353, EBI-6875961;
CC Q3SYF9; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10241353, EBI-3867333;
CC Q3SYF9; O75553: DAB1; NbExp=3; IntAct=EBI-10241353, EBI-7875264;
CC Q3SYF9; Q15038: DAZAP2; NbExp=3; IntAct=EBI-10241353, EBI-724310;
CC Q3SYF9; P50570-2: DNM2; NbExp=3; IntAct=EBI-10241353, EBI-10968534;
CC Q3SYF9; Q86UW9: DTX2; NbExp=3; IntAct=EBI-10241353, EBI-740376;
CC Q3SYF9; Q03828: EVX2; NbExp=3; IntAct=EBI-10241353, EBI-17280301;
CC Q3SYF9; Q92567-2: FAM168A; NbExp=3; IntAct=EBI-10241353, EBI-11978259;
CC Q3SYF9; P22607: FGFR3; NbExp=3; IntAct=EBI-10241353, EBI-348399;
CC Q3SYF9; O60548: FOXD2; NbExp=3; IntAct=EBI-10241353, EBI-17282008;
CC Q3SYF9; O75593: FOXH1; NbExp=3; IntAct=EBI-10241353, EBI-1759806;
CC Q3SYF9; Q12951-2: FOXI1; NbExp=3; IntAct=EBI-10241353, EBI-12018822;
CC Q3SYF9; Q9BZE0: GLIS2; NbExp=3; IntAct=EBI-10241353, EBI-7251368;
CC Q3SYF9; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-10241353, EBI-11975289;
CC Q3SYF9; P28799: GRN; NbExp=3; IntAct=EBI-10241353, EBI-747754;
CC Q3SYF9; P06396: GSN; NbExp=3; IntAct=EBI-10241353, EBI-351506;
CC Q3SYF9; Q9H4S2: GSX1; NbExp=3; IntAct=EBI-10241353, EBI-18011701;
CC Q3SYF9; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-10241353, EBI-748420;
CC Q3SYF9; P49639: HOXA1; NbExp=3; IntAct=EBI-10241353, EBI-740785;
CC Q3SYF9; Q9ULV5-2: HSF4; NbExp=3; IntAct=EBI-10241353, EBI-12056251;
CC Q3SYF9; P04792: HSPB1; NbExp=3; IntAct=EBI-10241353, EBI-352682;
CC Q3SYF9; P78412: IRX6; NbExp=3; IntAct=EBI-10241353, EBI-12100506;
CC Q3SYF9; O60333-2: KIF1B; NbExp=3; IntAct=EBI-10241353, EBI-10975473;
CC Q3SYF9; Q92876: KLK6; NbExp=3; IntAct=EBI-10241353, EBI-2432309;
CC Q3SYF9; Q5T749: KPRP; NbExp=3; IntAct=EBI-10241353, EBI-10981970;
CC Q3SYF9; O76011: KRT34; NbExp=3; IntAct=EBI-10241353, EBI-1047093;
CC Q3SYF9; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-10241353, EBI-10171774;
CC Q3SYF9; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10241353, EBI-11953334;
CC Q3SYF9; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-10241353, EBI-10176396;
CC Q3SYF9; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-10241353, EBI-3957672;
CC Q3SYF9; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-10241353, EBI-3957694;
CC Q3SYF9; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-10241353, EBI-1044640;
CC Q3SYF9; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-10241353, EBI-2341787;
CC Q3SYF9; Q8NDC0: MAPK1IP1L; NbExp=3; IntAct=EBI-10241353, EBI-741424;
CC Q3SYF9; Q13064: MKRN3; NbExp=3; IntAct=EBI-10241353, EBI-2340269;
CC Q3SYF9; Q96HR8: NAF1; NbExp=3; IntAct=EBI-10241353, EBI-2515597;
CC Q3SYF9; Q8WWR8-2: NEU4; NbExp=3; IntAct=EBI-10241353, EBI-10277551;
CC Q3SYF9; A8MTQ0: NOTO; NbExp=3; IntAct=EBI-10241353, EBI-17490746;
CC Q3SYF9; Q86UR1-2: NOXA1; NbExp=3; IntAct=EBI-10241353, EBI-12025760;
CC Q3SYF9; P32242: OTX1; NbExp=3; IntAct=EBI-10241353, EBI-740446;
CC Q3SYF9; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-10241353, EBI-11022007;
CC Q3SYF9; P23759-2: PAX7; NbExp=3; IntAct=EBI-10241353, EBI-12859446;
CC Q3SYF9; P78337: PITX1; NbExp=3; IntAct=EBI-10241353, EBI-748265;
CC Q3SYF9; Q99697-2: PITX2; NbExp=3; IntAct=EBI-10241353, EBI-12138495;
CC Q3SYF9; Q9NRY6: PLSCR3; NbExp=3; IntAct=EBI-10241353, EBI-750734;
CC Q3SYF9; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-10241353, EBI-769257;
CC Q3SYF9; Q16633: POU2AF1; NbExp=3; IntAct=EBI-10241353, EBI-943588;
CC Q3SYF9; Q12837: POU4F2; NbExp=3; IntAct=EBI-10241353, EBI-17236143;
CC Q3SYF9; O75360: PROP1; NbExp=3; IntAct=EBI-10241353, EBI-9027467;
CC Q3SYF9; Q9NZ81: PRR13; NbExp=3; IntAct=EBI-10241353, EBI-740924;
CC Q3SYF9; P20618: PSMB1; NbExp=3; IntAct=EBI-10241353, EBI-372273;
CC Q3SYF9; P49721: PSMB2; NbExp=3; IntAct=EBI-10241353, EBI-359335;
CC Q3SYF9; Q93062: RBPMS; NbExp=3; IntAct=EBI-10241353, EBI-740322;
CC Q3SYF9; Q93062-3: RBPMS; NbExp=6; IntAct=EBI-10241353, EBI-740343;
CC Q3SYF9; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-10241353, EBI-11987469;
CC Q3SYF9; Q9BQY4: RHOXF2; NbExp=6; IntAct=EBI-10241353, EBI-372094;
CC Q3SYF9; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-10241353, EBI-396669;
CC Q3SYF9; Q7L0R7: RNF44; NbExp=3; IntAct=EBI-10241353, EBI-2845060;
CC Q3SYF9; Q01974: ROR2; NbExp=3; IntAct=EBI-10241353, EBI-6422642;
CC Q3SYF9; Q16637: SMN2; NbExp=6; IntAct=EBI-10241353, EBI-395421;
CC Q3SYF9; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-10241353, EBI-11959123;
CC Q3SYF9; O15273: TCAP; NbExp=3; IntAct=EBI-10241353, EBI-954089;
CC Q3SYF9; Q9NQB0-10: TCF7L2; NbExp=3; IntAct=EBI-10241353, EBI-11746252;
CC Q3SYF9; Q96M29: TEKT5; NbExp=3; IntAct=EBI-10241353, EBI-10239812;
CC Q3SYF9; Q96LM6: TEX37; NbExp=3; IntAct=EBI-10241353, EBI-743976;
CC Q3SYF9; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-10241353, EBI-11952651;
CC Q3SYF9; Q08117-2: TLE5; NbExp=3; IntAct=EBI-10241353, EBI-11741437;
CC Q3SYF9; O43711: TLX3; NbExp=3; IntAct=EBI-10241353, EBI-3939165;
CC Q3SYF9; Q15025: TNIP1; NbExp=3; IntAct=EBI-10241353, EBI-357849;
CC Q3SYF9; Q9H0E2: TOLLIP; NbExp=3; IntAct=EBI-10241353, EBI-74615;
CC Q3SYF9; Q8N7U7-2: TPRX1; NbExp=3; IntAct=EBI-10241353, EBI-14115717;
CC Q3SYF9; Q08AM6: VAC14; NbExp=6; IntAct=EBI-10241353, EBI-2107455;
CC Q3SYF9; O95231: VENTX; NbExp=3; IntAct=EBI-10241353, EBI-10191303;
CC Q3SYF9; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-10241353, EBI-11957216;
CC Q3SYF9; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-10241353, EBI-2559305;
CC Q3SYF9; O76024: WFS1; NbExp=3; IntAct=EBI-10241353, EBI-720609;
CC Q3SYF9; Q15915: ZIC1; NbExp=3; IntAct=EBI-10241353, EBI-11963196;
CC -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
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DR EMBL; AB096949; BAE46364.1; -; mRNA.
DR EMBL; BC103836; AAI03837.1; -; mRNA.
DR EMBL; BC103837; AAI03838.1; -; mRNA.
DR EMBL; BC103838; AAI03839.1; -; mRNA.
DR CCDS; CCDS13599.1; -.
DR RefSeq; NP_853645.1; NM_181614.1.
DR AlphaFoldDB; Q3SYF9; -.
DR BioGRID; 130657; 116.
DR IntAct; Q3SYF9; 90.
DR STRING; 9606.ENSP00000334696; -.
DR iPTMnet; Q3SYF9; -.
DR PhosphoSitePlus; Q3SYF9; -.
DR BioMuta; KRTAP19-7; -.
DR DMDM; 88909173; -.
DR MassIVE; Q3SYF9; -.
DR PaxDb; Q3SYF9; -.
DR PeptideAtlas; Q3SYF9; -.
DR PRIDE; Q3SYF9; -.
DR ProteomicsDB; 61860; -.
DR DNASU; 337974; -.
DR Ensembl; ENST00000334849.2; ENSP00000334696.2; ENSG00000244362.3.
DR GeneID; 337974; -.
DR KEGG; hsa:337974; -.
DR MANE-Select; ENST00000334849.2; ENSP00000334696.2; NM_181614.3; NP_853645.1.
DR UCSC; uc011adb.3; human.
DR CTD; 337974; -.
DR GeneCards; KRTAP19-7; -.
DR HGNC; HGNC:18942; KRTAP19-7.
DR HPA; ENSG00000244362; Not detected.
DR neXtProt; NX_Q3SYF9; -.
DR PharmGKB; PA134868084; -.
DR VEuPathDB; HostDB:ENSG00000244362; -.
DR eggNOG; ENOG502THDW; Eukaryota.
DR GeneTree; ENSGT00950000183791; -.
DR InParanoid; Q3SYF9; -.
DR OMA; YGRYCSS; -.
DR PathwayCommons; Q3SYF9; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q3SYF9; -.
DR BioGRID-ORCS; 337974; 33 hits in 995 CRISPR screens.
DR GenomeRNAi; 337974; -.
DR Pharos; Q3SYF9; Tdark.
DR PRO; PR:Q3SYF9; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q3SYF9; protein.
DR Bgee; ENSG00000244362; Expressed in cell and 8 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR Pfam; PF11759; KRTAP; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..63
FT /note="Keratin-associated protein 19-7"
FT /id="PRO_0000223909"
SQ SEQUENCE 63 AA; 6644 MW; AC24810FC35B6F09 CRC64;
MSYSGSYYGG LGYGCGGFGG LGYGYSCGCG SFRRLGYGCG YGGYRYSCCH PSCYGGYWSS
GFY
