ID   KR198_HUMAN             Reviewed;          63 AA.
AC   Q3LI54;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Keratin-associated protein 19-8;
GN   Name=KRTAP19-8; Synonyms=KAP19.8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hair root;
RA   Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT   "Identification of complete keratin-associated protein (KAP) gene cluster
RT   spanning 800 kb region on human chromosome 21q22.11.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 19 family. {ECO:0000305}.
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DR   EMBL; AB096964; BAE46379.1; -; mRNA.
DR   CCDS; CCDS42917.1; -.
DR   RefSeq; NP_001092689.1; NM_001099219.1.
DR   AlphaFoldDB; Q3LI54; -.
DR   STRING; 9606.ENSP00000372272; -.
DR   BioMuta; KRTAP19-8; -.
DR   DMDM; 121942682; -.
DR   PaxDb; Q3LI54; -.
DR   PRIDE; Q3LI54; -.
DR   DNASU; 728299; -.
DR   Ensembl; ENST00000382822.2; ENSP00000372272.2; ENSG00000206102.2.
DR   GeneID; 728299; -.
DR   KEGG; hsa:728299; -.
DR   MANE-Select; ENST00000382822.2; ENSP00000372272.2; NM_001099219.1; NP_001092689.1.
DR   UCSC; uc010glt.3; human.
DR   CTD; 728299; -.
DR   GeneCards; KRTAP19-8; -.
DR   HGNC; HGNC:33898; KRTAP19-8.
DR   HPA; ENSG00000206102; Not detected.
DR   neXtProt; NX_Q3LI54; -.
DR   OpenTargets; ENSG00000206102; -.
DR   PharmGKB; PA162393748; -.
DR   VEuPathDB; HostDB:ENSG00000206102; -.
DR   eggNOG; ENOG502TDP7; Eukaryota.
DR   GeneTree; ENSGT00950000183564; -.
DR   HOGENOM; CLU_184630_0_0_1; -.
DR   InParanoid; Q3LI54; -.
DR   OMA; GRFRYCC; -.
DR   PathwayCommons; Q3LI54; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   SignaLink; Q3LI54; -.
DR   BioGRID-ORCS; 728299; 15 hits in 1022 CRISPR screens.
DR   GenomeRNAi; 728299; -.
DR   Pharos; Q3LI54; Tdark.
DR   PRO; PR:Q3LI54; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q3LI54; protein.
DR   Bgee; ENSG00000206102; Expressed in granulocyte and 41 other tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR   Pfam; PF11759; KRTAP; 1.
PE   3: Inferred from homology;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..63
FT                   /note="Keratin-associated protein 19-8"
FT                   /id="PRO_0000307914"
FT   VARIANT         61
FT                   /note="A -> T (in dbSNP:rs7279142)"
FT                   /id="VAR_053476"
SQ   SEQUENCE   63 AA;  6918 MW;  09E429255B029FC2 CRC64;
     MSYYRSYYGG LGYGYGGFGG WGYGYGCGYG SFRRLGYGCG YGGYGFSCCR PLYYGGYGFS
     AFY