ID   KR203_HUMAN             Reviewed;          44 AA.
AC   Q3LI60;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Keratin-associated protein 20-3;
GN   Name=KRTAP20-3; Synonyms=KAP20.3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hair root;
RA   Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT   "Identification of complete keratin-associated protein (KAP) gene cluster
RT   spanning 800 kb region on human chromosome 21q22.11.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 20 family. {ECO:0000305}.
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DR   EMBL; AB096958; BAE46373.1; -; mRNA.
DR   CCDS; CCDS46642.1; -.
DR   RefSeq; NP_001121549.1; NM_001128077.1.
DR   AlphaFoldDB; Q3LI60; -.
DR   STRING; 9606.ENSP00000372276; -.
DR   iPTMnet; Q3LI60; -.
DR   PhosphoSitePlus; Q3LI60; -.
DR   BioMuta; KRTAP20-3; -.
DR   PaxDb; Q3LI60; -.
DR   PRIDE; Q3LI60; -.
DR   Antibodypedia; 64691; 4 antibodies from 4 providers.
DR   DNASU; 337985; -.
DR   Ensembl; ENST00000382826.2; ENSP00000372276.2; ENSG00000206104.2.
DR   GeneID; 337985; -.
DR   KEGG; hsa:337985; -.
DR   MANE-Select; ENST00000382826.2; ENSP00000372276.2; NM_001128077.1; NP_001121549.1.
DR   UCSC; uc010gls.1; human.
DR   CTD; 337985; -.
DR   GeneCards; KRTAP20-3; -.
DR   HGNC; HGNC:34001; KRTAP20-3.
DR   HPA; ENSG00000206104; Not detected.
DR   neXtProt; NX_Q3LI60; -.
DR   PharmGKB; PA162393749; -.
DR   VEuPathDB; HostDB:ENSG00000206104; -.
DR   eggNOG; ENOG502TM3U; Eukaryota.
DR   GeneTree; ENSGT00410000029383; -.
DR   HOGENOM; CLU_3224409_0_0_1; -.
DR   InParanoid; Q3LI60; -.
DR   TreeFam; TF343720; -.
DR   PathwayCommons; Q3LI60; -.
DR   SignaLink; Q3LI60; -.
DR   BioGRID-ORCS; 337985; 13 hits in 1051 CRISPR screens.
DR   GenomeRNAi; 337985; -.
DR   Pharos; Q3LI60; Tdark.
DR   PRO; PR:Q3LI60; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000206104; Expressed in granulocyte and 2 other tissues.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..44
FT                   /note="Keratin-associated protein 20-3"
FT                   /id="PRO_0000307915"
SQ   SEQUENCE   44 AA;  4909 MW;  9055AE27F398E1F5 CRC64;
     MSYYGNYYGG LGYGYDCKYS YTSGFGAFRI LDCGYRCGCG GVWI