ID   KR204_HUMAN             Reviewed;          44 AA.
AC   Q3LI62;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=Putative keratin-associated protein 20-4;
GN   Name=KRTAP20-4; Synonyms=KAP20.4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hair root;
RA   Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT   "Identification of complete keratin-associated protein (KAP) gene cluster
RT   spanning 800 kb region on human chromosome 21q22.11.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 20 family. {ECO:0000305}.
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DR   EMBL; AB096956; BAE46371.1; -; mRNA.
DR   CCDS; CCDS86982.1; -.
DR   AlphaFoldDB; Q3LI62; -.
DR   STRING; 9606.ENSP00000372278; -.
DR   BioMuta; KRTAP20-4; -.
DR   PaxDb; Q3LI62; -.
DR   PRIDE; Q3LI62; -.
DR   Antibodypedia; 48650; 5 antibodies from 1 providers.
DR   Ensembl; ENST00000382828.2; ENSP00000372278.2; ENSG00000206105.2.
DR   MANE-Select; ENST00000382828.2; ENSP00000372278.2; NM_001350977.1; NP_001337906.1.
DR   UCSC; uc011adf.2; human.
DR   GeneCards; KRTAP20-4; -.
DR   HGNC; HGNC:34002; KRTAP20-4.
DR   HPA; ENSG00000206105; Tissue enriched (testis).
DR   neXtProt; NX_Q3LI62; -.
DR   VEuPathDB; HostDB:ENSG00000206105; -.
DR   eggNOG; ENOG502TEWP; Eukaryota.
DR   GeneTree; ENSGT01000000215755; -.
DR   HOGENOM; CLU_3361965_0_0_1; -.
DR   InParanoid; Q3LI62; -.
DR   Pharos; Q3LI62; Tdark.
DR   PRO; PR:Q3LI62; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000206105; Expressed in right testis and 22 other tissues.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..44
FT                   /note="Putative keratin-associated protein 20-4"
FT                   /id="PRO_0000308250"
SQ   SEQUENCE   44 AA;  4623 MW;  E21C8698A54D1814 CRC64;
     MSYYSHLSGG LGCGLAVAVT MGRTVAVAEY GRCRHGCHSS YSAR