KR211_MOUSE
ID KR211_MOUSE Reviewed; 128 AA.
AC Q925H4; Q9D1B6;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 25-MAY-2022, entry version 65.
DE RecName: Full=Keratin-associated protein 21-1;
DE AltName: Full=Keratin-associated protein 16-7 {ECO:0000312|MGI:MGI:2157767};
DE AltName: Full=Keratin-associated protein 16.7 {ECO:0000312|EMBL:AAK52895.1};
GN Name=Krtap21-1;
GN Synonyms=Krtap16-7, Krtap16.7 {ECO:0000312|EMBL:AAK52895.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK52895.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC STRAIN=FVB/NJ {ECO:0000312|EMBL:AAK52895.1};
RC TISSUE=Skin {ECO:0000269|PubMed:11290294};
RX PubMed=11290294; DOI=10.1242/dev.128.9.1547;
RA Tkatchenko A.V., Visconti R.P., Shang L., Papenbrock T., Pruett N.D.,
RA Ito T., Ogawa M., Awgulewitsch A.;
RT "Overexpression of Hoxc13 in differentiating keratinocytes results in
RT downregulation of a novel hair keratin gene cluster and alopecia.";
RL Development 128:1547-1558(2001).
RN [2] {ECO:0000312|EMBL:BAB22970.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB22970.2};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAB22970.2};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15385554; DOI=10.1074/jbc.m404331200;
RA Pruett N.D., Tkatchenko T.V., Jave-Suarez L., Jacobs D.F., Potter C.S.,
RA Tkatchenko A.V., Schweizer J., Awgulewitsch A.;
RT "Krtap16, characterization of a new hair keratin-associated protein (KAP)
RT gene complex on mouse chromosome 16 and evidence for regulation by
RT Hoxc13.";
RL J. Biol. Chem. 279:51524-51533(2004).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY, AND INDUCTION.
RX PubMed=17151017; DOI=10.1242/dev.02721;
RA Kurek D., Garinis G.A., van Doorninck J.H., van der Wees J., Grosveld F.G.;
RT "Transcriptome and phenotypic analysis reveals Gata3-dependent signalling
RT pathways in murine hair follicles.";
RL Development 134:261-272(2007).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strong expression in narrowly defined pattern
CC restricted to the lower and middle cortical regions of the hair shaft
CC in both developing and cycling hair. During hair follicle regression
CC (catagen), expression levels decrease until expression is no longer
CC detectable in follicles at resting stage (telogen).
CC {ECO:0000269|PubMed:15385554, ECO:0000269|PubMed:17151017}.
CC -!- INDUCTION: Expression in skin and hair follicle is regulated by HOXC13
CC and by GATA3. {ECO:0000269|PubMed:11290294,
CC ECO:0000269|PubMed:17151017}.
CC -!- SIMILARITY: Belongs to the KRTAP type 21 family. {ECO:0000305}.
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DR EMBL; AF345297; AAK52895.1; -; mRNA.
DR EMBL; AK003736; BAB22970.2; -; mRNA.
DR CCDS; CCDS28311.1; -.
DR AlphaFoldDB; Q925H4; -.
DR STRING; 10090.ENSMUSP00000077524; -.
DR iPTMnet; Q925H4; -.
DR PhosphoSitePlus; Q925H4; -.
DR PaxDb; Q925H4; -.
DR PRIDE; Q925H4; -.
DR MGI; MGI:2157767; Krtap21-1.
DR eggNOG; ENOG502S2E1; Eukaryota.
DR PRO; PR:Q925H4; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q925H4; protein.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0008283; P:cell population proliferation; IMP:MGI.
DR GO; GO:0048589; P:developmental growth; IMP:MGI.
DR GO; GO:0022405; P:hair cycle process; IMP:MGI.
DR GO; GO:0001942; P:hair follicle development; IMP:MGI.
DR GO; GO:0043480; P:pigment accumulation in tissues; IMP:MGI.
DR GO; GO:0031077; P:post-embryonic camera-type eye development; IMP:MGI.
DR GO; GO:0051726; P:regulation of cell cycle; IMP:MGI.
DR GO; GO:0007165; P:signal transduction; IMP:MGI.
DR GO; GO:0043588; P:skin development; IMP:MGI.
DR InterPro; IPR021743; KRTAP_type6/8/16/19/20/21.
DR Pfam; PF11759; KRTAP; 1.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..128
FT /note="Keratin-associated protein 21-1"
FT /id="PRO_0000356216"
FT REGION 11..117
FT /note="51 X 2 AA repeats of G-[YCGS]"
FT /evidence="ECO:0000255"
FT CONFLICT 76
FT /note="G -> S (in Ref. 1; AAK52895)"
FT /evidence="ECO:0000305"
FT CONFLICT 99
FT /note="S -> T (in Ref. 1; AAK52895)"
FT /evidence="ECO:0000305"
FT CONFLICT 113
FT /note="Y -> C (in Ref. 1; AAK52895)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 128 AA; 12539 MW; 4C49BAA5F2D6ECEE CRC64;
MCCNYYGNSC GGCGYGSRYG YGCGYGSGYG CGYGSGYGCG YGSGYGCGYG SGYGCGYGSG
YGCGYGSGYG CGYGSGYGCG YGSGYGCGYG SGYGCGYGSG YGCGYGSRYG CGYGSGCCSY
RKCYSSCC
