ID   KR213_HUMAN             Reviewed;          58 AA.
AC   Q3LHN1;
DT   13-OCT-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Keratin-associated protein 21-3;
GN   Name=KRTAP21-3; Synonyms=KAP21.3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Testis;
RA   Obayashi I., Shibuya K., Kudoh J., Shimizu N.;
RT   "Identification of eight novel genes from keratin associated protein gene
RT   cluster on human chromosome 21q22.11.";
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
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DR   EMBL; AB180042; BAE46381.1; -; mRNA.
DR   CCDS; CCDS54481.1; -.
DR   RefSeq; NP_001157907.1; NM_001164435.1.
DR   AlphaFoldDB; Q3LHN1; -.
DR   STRING; 9606.ENSP00000404517; -.
DR   BioMuta; KRTAP21-3; -.
DR   PaxDb; Q3LHN1; -.
DR   PRIDE; Q3LHN1; -.
DR   Antibodypedia; 62466; 10 antibodies from 6 providers.
DR   DNASU; 100288323; -.
DR   Ensembl; ENST00000444335.1; ENSP00000404517.1; ENSG00000231068.1.
DR   GeneID; 100288323; -.
DR   KEGG; hsa:100288323; -.
DR   MANE-Select; ENST00000444335.1; ENSP00000404517.1; NM_001164435.1; NP_001157907.1.
DR   UCSC; uc021wii.1; human.
DR   CTD; 100288323; -.
DR   GeneCards; KRTAP21-3; -.
DR   HGNC; HGNC:34216; KRTAP21-3.
DR   HPA; ENSG00000231068; Not detected.
DR   neXtProt; NX_Q3LHN1; -.
DR   OpenTargets; ENSG00000231068; -.
DR   PharmGKB; PA165378419; -.
DR   VEuPathDB; HostDB:ENSG00000231068; -.
DR   eggNOG; ENOG502TDYT; Eukaryota.
DR   GeneTree; ENSGT00550000076392; -.
DR   HOGENOM; CLU_2978495_0_0_1; -.
DR   InParanoid; Q3LHN1; -.
DR   OMA; STHCGCN; -.
DR   OrthoDB; 1641373at2759; -.
DR   PathwayCommons; Q3LHN1; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   SignaLink; Q3LHN1; -.
DR   BioGRID-ORCS; 100288323; 9 hits in 1012 CRISPR screens.
DR   Pharos; Q3LHN1; Tdark.
DR   PRO; PR:Q3LHN1; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q3LHN1; protein.
DR   Bgee; ENSG00000231068; Expressed in cell and 22 other tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..58
FT                   /note="Keratin-associated protein 21-3"
FT                   /id="PRO_0000386448"
SQ   SEQUENCE   58 AA;  6456 MW;  61DA00333BEF8A45 CRC64;
     MYFNYKSVCG SCGFGSCYGC GYGCIHSTHC GCNGYYGCYE NKYSVIDDLI FFASKKCH