ID   ARC1A_RAT               Reviewed;         370 AA.
AC   Q99PD4;
DT   15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 113.
DE   RecName: Full=Actin-related protein 2/3 complex subunit 1A;
GN   Name=Arpc1a;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley; TISSUE=Kidney;
RA   Jia Y., Ransom R.F., Welsh M.J., Smoyer W.E.;
RT   "cDNA coding sequence of mammalian sop2p (suppressor of profilin)/p41arc
RT   (p41 of actin-related complex 2/3).";
RL   Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Probably functions as component of the Arp2/3 complex which
CC       is involved in regulation of actin polymerization and together with an
CC       activating nucleation-promoting factor (NPF) mediates the formation of
CC       branched actin networks (By similarity). In addition to its role in the
CC       cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin
CC       polymerization in the nucleus, thereby regulating gene transcription
CC       and repair of damaged DNA (By similarity).
CC       {ECO:0000250|UniProtKB:Q8AVT9, ECO:0000250|UniProtKB:Q92747}.
CC   -!- SUBUNIT: Probable component of the Arp2/3 complex in which it may
CC       replace ARPC1B. {ECO:0000250|UniProtKB:Q92747}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000250|UniProtKB:Q92747}. Nucleus {ECO:0000250|UniProtKB:Q8AVT9}.
CC   -!- SIMILARITY: Belongs to the WD repeat ARPC1 family. {ECO:0000305}.
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DR   EMBL; AF315378; AAK01364.1; -; mRNA.
DR   RefSeq; NP_112408.1; NM_031146.2.
DR   AlphaFoldDB; Q99PD4; -.
DR   SMR; Q99PD4; -.
DR   BioGRID; 249682; 3.
DR   IntAct; Q99PD4; 1.
DR   STRING; 10116.ENSRNOP00000001319; -.
DR   iPTMnet; Q99PD4; -.
DR   PhosphoSitePlus; Q99PD4; -.
DR   SwissPalm; Q99PD4; -.
DR   jPOST; Q99PD4; -.
DR   PaxDb; Q99PD4; -.
DR   PRIDE; Q99PD4; -.
DR   GeneID; 81824; -.
DR   KEGG; rno:81824; -.
DR   CTD; 10552; -.
DR   RGD; 620834; Arpc1a.
DR   eggNOG; KOG1523; Eukaryota.
DR   InParanoid; Q99PD4; -.
DR   OrthoDB; 848569at2759; -.
DR   PhylomeDB; Q99PD4; -.
DR   Reactome; R-RNO-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR   Reactome; R-RNO-3928662; EPHB-mediated forward signaling.
DR   Reactome; R-RNO-5663213; RHO GTPases Activate WASPs and WAVEs.
DR   Reactome; R-RNO-8856828; Clathrin-mediated endocytosis.
DR   PRO; PR:Q99PD4; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005885; C:Arp2/3 protein complex; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0036195; C:muscle cell projection membrane; ISO:RGD.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035861; C:site of double-strand break; ISS:UniProtKB.
DR   GO; GO:0051015; F:actin filament binding; IBA:GO_Central.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR030140; ARC1A.
DR   InterPro; IPR017383; ARPC1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10709; PTHR10709; 1.
DR   PANTHER; PTHR10709:SF11; PTHR10709:SF11; 1.
DR   Pfam; PF00400; WD40; 2.
DR   PIRSF; PIRSF038093; ARP2/3_su1; 1.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Nucleus; Reference proteome;
KW   Repeat; WD repeat.
FT   CHAIN           1..370
FT                   /note="Actin-related protein 2/3 complex subunit 1A"
FT                   /id="PRO_0000050854"
FT   REPEAT          6..45
FT                   /note="WD 1"
FT   REPEAT          50..89
FT                   /note="WD 2"
FT   REPEAT          140..179
FT                   /note="WD 3"
FT   REPEAT          202..241
FT                   /note="WD 4"
FT   REPEAT          244..284
FT                   /note="WD 5"
FT   REPEAT          322..365
FT                   /note="WD 6"
SQ   SEQUENCE   370 AA;  41599 MW;  1A7DCE8E93BF11AC CRC64;
     MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGS QWTKAHELKE HNGHITGIDW
     APKSDRIVTC GADRNAYVWS QKDGIWKPTL VILRINRAAT FVKWSPLENK FAVGSGARLI
     SVCYFESEND WWVSKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKCRVFS AYIKEVDEKP
     ASTPWGSKMP FGQLMSEFGG SGTGGWVHGV SFSASGSRLA WVSHDSTVSV ADASKSVQVS
     TLRTEFLPLL SVSFVSENSV VAAGHDCCPM LFNYDDRGCL TFVSKLDVPK QSIQRNMSAM
     ERFRNMDKRA TTEDRNTALE TLHQNSITQV SIYEVDKQDC RKFCTTGIDG AMTIWDFKTL
     ESSIQGLRIM