ID   KR222_HUMAN             Reviewed;          45 AA.
AC   Q3LI68;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Keratin-associated protein 22-2;
GN   Name=KRTAP22-2; Synonyms=KAP22.2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hair root;
RA   Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT   "Identification of complete keratin-associated protein (KAP) gene cluster
RT   spanning 800 kb region on human chromosome 21q22.11.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 20 family. {ECO:0000305}.
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DR   EMBL; AB096950; BAE46365.1; -; mRNA.
DR   CCDS; CCDS46641.1; -.
DR   RefSeq; NP_001157906.1; NM_001164434.1.
DR   AlphaFoldDB; Q3LI68; -.
DR   STRING; 9606.ENSP00000372281; -.
DR   BioMuta; KRTAP22-2; -.
DR   PaxDb; Q3LI68; -.
DR   PeptideAtlas; Q3LI68; -.
DR   PRIDE; Q3LI68; -.
DR   DNASU; 100288287; -.
DR   Ensembl; ENST00000382830.2; ENSP00000372281.2; ENSG00000206106.2.
DR   GeneID; 100288287; -.
DR   KEGG; hsa:100288287; -.
DR   MANE-Select; ENST00000382830.2; ENSP00000372281.2; NM_001164434.1; NP_001157906.1.
DR   UCSC; uc021wih.1; human.
DR   CTD; 100288287; -.
DR   GeneCards; KRTAP22-2; -.
DR   HGNC; HGNC:37091; KRTAP22-2.
DR   HPA; ENSG00000206106; Not detected.
DR   neXtProt; NX_Q3LI68; -.
DR   PharmGKB; PA165378424; -.
DR   VEuPathDB; HostDB:ENSG00000206106; -.
DR   eggNOG; ENOG502TFXJ; Eukaryota.
DR   GeneTree; ENSGT00530000065184; -.
DR   HOGENOM; CLU_184630_2_0_1; -.
DR   InParanoid; Q3LI68; -.
DR   OrthoDB; 1621149at2759; -.
DR   PhylomeDB; Q3LI68; -.
DR   TreeFam; TF339853; -.
DR   BioGRID-ORCS; 100288287; 14 hits in 1032 CRISPR screens.
DR   Pharos; Q3LI68; Tdark.
DR   PRO; PR:Q3LI68; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   Bgee; ENSG00000206106; Expressed in cell and 14 other tissues.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Keratin; Reference proteome.
FT   CHAIN           1..45
FT                   /note="Keratin-associated protein 22-2"
FT                   /id="PRO_0000336084"
SQ   SEQUENCE   45 AA;  5218 MW;  702FAF8F143A0EDD CRC64;
     MCYYHNYYGS LDYGCSYGSE YGNSGYACNF PCSYGRFLLA PRKKF