KR231_HUMAN
ID KR231_HUMAN Reviewed; 65 AA.
AC A1A580;
DT 12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Keratin-associated protein 23-1;
GN Name=KRTAP23-1; Synonyms=KAP23.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC A1A580; O14503: BHLHE40; NbExp=3; IntAct=EBI-10171734, EBI-711810;
CC A1A580; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-10171734, EBI-11976299;
CC A1A580; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-10171734, EBI-1383687;
CC A1A580; P49639: HOXA1; NbExp=3; IntAct=EBI-10171734, EBI-740785;
CC A1A580; Q93062: RBPMS; NbExp=3; IntAct=EBI-10171734, EBI-740322;
CC A1A580; Q96LM6: TEX37; NbExp=3; IntAct=EBI-10171734, EBI-743976;
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DR EMBL; BC128435; AAI28436.1; -; mRNA.
DR CCDS; CCDS33533.1; -.
DR RefSeq; NP_853655.1; NM_181624.1.
DR AlphaFoldDB; A1A580; -.
DR BioGRID; 130646; 8.
DR IntAct; A1A580; 7.
DR STRING; 9606.ENSP00000346536; -.
DR BioMuta; KRTAP23-1; -.
DR PaxDb; A1A580; -.
DR PeptideAtlas; A1A580; -.
DR PRIDE; A1A580; -.
DR Antibodypedia; 6613; 51 antibodies from 13 providers.
DR DNASU; 337963; -.
DR Ensembl; ENST00000334160.6; ENSP00000346536.3; ENSG00000186980.7.
DR GeneID; 337963; -.
DR KEGG; hsa:337963; -.
DR MANE-Select; ENST00000334160.6; ENSP00000346536.3; NM_181624.1; NP_853655.1.
DR UCSC; uc002yny.2; human.
DR CTD; 337963; -.
DR GeneCards; KRTAP23-1; -.
DR HGNC; HGNC:18928; KRTAP23-1.
DR HPA; ENSG00000186980; Not detected.
DR neXtProt; NX_A1A580; -.
DR OpenTargets; ENSG00000186980; -.
DR PharmGKB; PA134978709; -.
DR VEuPathDB; HostDB:ENSG00000186980; -.
DR eggNOG; ENOG502TEIG; Eukaryota.
DR GeneTree; ENSGT00940000170816; -.
DR HOGENOM; CLU_2885221_0_0_1; -.
DR InParanoid; A1A580; -.
DR OMA; CGGYLCY; -.
DR PhylomeDB; A1A580; -.
DR TreeFam; TF341533; -.
DR PathwayCommons; A1A580; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; A1A580; -.
DR BioGRID-ORCS; 337963; 15 hits in 1058 CRISPR screens.
DR GenomeRNAi; 337963; -.
DR Pharos; A1A580; Tdark.
DR PRO; PR:A1A580; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; A1A580; protein.
DR Bgee; ENSG00000186980; Expressed in cell and 23 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR007951; KRTAP_PMG.
DR Pfam; PF05287; PMG; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..65
FT /note="Keratin-associated protein 23-1"
FT /id="PRO_0000290066"
SQ SEQUENCE 65 AA; 6892 MW; 306C2057359CD049 CRC64;
MSYNCCCGNF SSHSCEGYLC YSGYSRGGSS YPSNLVYSTE PLISQHLPAG FLSLQGLSGD
LLGNP
