ID   KR241_HUMAN             Reviewed;         254 AA.
AC   Q3LI83; Q1XDX0;
DT   21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=Keratin-associated protein 24-1;
GN   Name=KRTAP24-1; Synonyms=KAP24.1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hair root;
RA   Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT   "Identification of complete keratin-associated protein (KAP) gene cluster
RT   spanning 800 kb region on human chromosome 21q22.11.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Scalp;
RX   PubMed=17235325; DOI=10.1038/sj.jid.5700702;
RA   Rogers M.A., Winter H., Langbein L., Wollschlaeger A., Praetzel-Wunder S.,
RA   Jave-Suarez L.F., Schweizer J.;
RT   "Characterization of human KAP24.1, a cuticular hair keratin-associated
RT   protein with unusual amino-acid composition and repeat structure.";
RL   J. Invest. Dermatol. 127:1197-1204(2007).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Specific expression in the middle/upper hair
CC       cuticle. {ECO:0000269|PubMed:17235325}.
CC   -!- MISCELLANEOUS: Has a low cysteine content when compared to the majority
CC       of known KAP family members. Possesses several C-terminal tyrosine-
CC       containing tandem decameric repeat structures.
CC   -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; AB096935; BAE46350.1; -; mRNA.
DR   EMBL; AM238513; CAJ87483.1; -; mRNA.
DR   CCDS; CCDS42915.1; -.
DR   RefSeq; NP_001078924.1; NM_001085455.2.
DR   AlphaFoldDB; Q3LI83; -.
DR   STRING; 9606.ENSP00000339238; -.
DR   PhosphoSitePlus; Q3LI83; -.
DR   BioMuta; KRTAP24-1; -.
DR   DMDM; 88909179; -.
DR   MassIVE; Q3LI83; -.
DR   PaxDb; Q3LI83; -.
DR   PeptideAtlas; Q3LI83; -.
DR   PRIDE; Q3LI83; -.
DR   ProteomicsDB; 61775; -.
DR   Antibodypedia; 22462; 29 antibodies from 14 providers.
DR   DNASU; 643803; -.
DR   Ensembl; ENST00000340345.6; ENSP00000339238.4; ENSG00000188694.6.
DR   GeneID; 643803; -.
DR   KEGG; hsa:643803; -.
DR   MANE-Select; ENST00000340345.6; ENSP00000339238.4; NM_001085455.3; NP_001078924.1.
DR   UCSC; uc002ynv.3; human.
DR   CTD; 643803; -.
DR   GeneCards; KRTAP24-1; -.
DR   HGNC; HGNC:33902; KRTAP24-1.
DR   HPA; ENSG00000188694; Tissue enriched (skin).
DR   MIM; 618927; gene.
DR   neXtProt; NX_Q3LI83; -.
DR   PharmGKB; PA162393751; -.
DR   VEuPathDB; HostDB:ENSG00000188694; -.
DR   eggNOG; ENOG502RR8N; Eukaryota.
DR   GeneTree; ENSGT00390000001157; -.
DR   HOGENOM; CLU_1146869_0_0_1; -.
DR   InParanoid; Q3LI83; -.
DR   OMA; LWLLDNC; -.
DR   OrthoDB; 1261407at2759; -.
DR   PhylomeDB; Q3LI83; -.
DR   TreeFam; TF337331; -.
DR   PathwayCommons; Q3LI83; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   BioGRID-ORCS; 643803; 12 hits in 1069 CRISPR screens.
DR   GenomeRNAi; 643803; -.
DR   Pharos; Q3LI83; Tdark.
DR   PRO; PR:Q3LI83; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q3LI83; protein.
DR   Bgee; ENSG00000188694; Expressed in skin of abdomen and 2 other tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR007659; Keratin_matx.
DR   InterPro; IPR007951; KRTAP_PMG.
DR   PANTHER; PTHR23260; PTHR23260; 1.
DR   Pfam; PF05287; PMG; 1.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..254
FT                   /note="Keratin-associated protein 24-1"
FT                   /id="PRO_0000223915"
FT   REPEAT          193..202
FT                   /note="1"
FT   REPEAT          203..212
FT                   /note="2"
FT   REPEAT          213..222
FT                   /note="3"
FT   REPEAT          223..232
FT                   /note="4"
FT   REPEAT          233..242
FT                   /note="5"
FT   REPEAT          243..252
FT                   /note="6"
FT   REGION          193..252
FT                   /note="6 X 10 AA repeats of Y-[ILR]-[SVPC]-[NRTS]-[SNTG]-X-
FT                   [QHRP]-[PSY]-[QSL]-[SRK]"
SQ   SEQUENCE   254 AA;  27719 MW;  18A51653AF7FDB59 CRC64;
     MPAGSMSTTG YPGVCSTTSY RTHCYIPVTS SVTLSSSDLS PTFGHCLPSS YQGNLWLLDY
     CQESYGEAPT CKSPSCEPKT CSTTGCDPSN SSVPCNSPSA GQVFSVCETT NVSPSPSCSP
     STQTNGYVCN CHIPTRNASK ACQTLRNGSN CFGQLNCLSK SFQTLNHCRL STLGYKSYQN
     PCFIPSYVSP LCYISNSCQP QSYLVRNYHY SSYRPTSCRP LSYLSRSFRS LSYIPSTFPP
     LRYLCSGSRP LKCY