ID   KR251_HUMAN             Reviewed;         102 AA.
AC   Q3LHN0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 85.
DE   RecName: Full=Keratin-associated protein 25-1;
GN   Name=KRTAP25-1; Synonyms=KAP25.1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hair root;
RA   Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT   "Identification of complete keratin-associated protein (KAP) gene cluster
RT   spanning 800 kb region on human chromosome 21q22.11.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}.
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DR   EMBL; AB180043; BAE46382.1; -; mRNA.
DR   CCDS; CCDS46640.1; -.
DR   RefSeq; NP_001122070.1; NM_001128598.1.
DR   AlphaFoldDB; Q3LHN0; -.
DR   STRING; 9606.ENSP00000398619; -.
DR   BioMuta; KRTAP25-1; -.
DR   DMDM; 121942679; -.
DR   PaxDb; Q3LHN0; -.
DR   PRIDE; Q3LHN0; -.
DR   Antibodypedia; 22465; 67 antibodies from 18 providers.
DR   DNASU; 100131902; -.
DR   Ensembl; ENST00000416044.1; ENSP00000398619.1; ENSG00000232263.1.
DR   GeneID; 100131902; -.
DR   KEGG; hsa:100131902; -.
DR   MANE-Select; ENST00000416044.1; ENSP00000398619.1; NM_001128598.1; NP_001122070.1.
DR   UCSC; uc010glr.1; human.
DR   CTD; 100131902; -.
DR   GeneCards; KRTAP25-1; -.
DR   HGNC; HGNC:34003; KRTAP25-1.
DR   HPA; ENSG00000232263; Not detected.
DR   neXtProt; NX_Q3LHN0; -.
DR   PharmGKB; PA162393758; -.
DR   VEuPathDB; HostDB:ENSG00000232263; -.
DR   eggNOG; ENOG502TCVB; Eukaryota.
DR   GeneTree; ENSGT00550000076318; -.
DR   HOGENOM; CLU_2365096_0_0_1; -.
DR   InParanoid; Q3LHN0; -.
DR   OMA; FVSRTCY; -.
DR   OrthoDB; 1490823at2759; -.
DR   PhylomeDB; Q3LHN0; -.
DR   PathwayCommons; Q3LHN0; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   BioGRID-ORCS; 100131902; 8 hits in 1022 CRISPR screens.
DR   GenomeRNAi; 100131902; -.
DR   Pharos; Q3LHN0; Tdark.
DR   PRO; PR:Q3LHN0; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q3LHN0; protein.
DR   Bgee; ENSG00000232263; Expressed in granulocyte and 2 other tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR007951; KRTAP_PMG.
DR   PANTHER; PTHR19051; PTHR19051; 1.
DR   Pfam; PF05287; PMG; 1.
PE   3: Inferred from homology;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..102
FT                   /note="Keratin-associated protein 25-1"
FT                   /id="PRO_0000308251"
FT   VARIANT         40
FT                   /note="S -> P (in dbSNP:rs8127420)"
FT                   /id="VAR_060063"
SQ   SEQUENCE   102 AA;  11738 MW;  82872CA797F3F983 CRC64;
     MHNRSQGFFF SSCHPQNHVS YGCQSPSFIF CRCQSLNFVS RTCYPLSYFS YGNQTIGSIS
     NSFRSLNYVS HSFQPISFMH SSFQPACSDF VGWQSPFLRR TC