KR261_HUMAN
ID KR261_HUMAN Reviewed; 210 AA.
AC Q6PEX3; B0RZD3;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Keratin-associated protein 26-1;
GN Name=KRTAP26-1; Synonyms=KAP26.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair root;
RA Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT "Identification of complete keratin-associated protein (KAP) gene cluster
RT spanning 800 kb region on human chromosome 21q22.11.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Scalp;
RX PubMed=18647308; DOI=10.1111/j.1365-2133.2008.08743.x;
RA Rogers M.A., Langbein L., Praetzel-Wunder S., Giehl K.;
RT "Characterization and expression analysis of the hair keratin associated
RT protein KAP26.1.";
RL Br. J. Dermatol. 159:725-729(2008).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q6PEX3; Q96HD9: ACY3; NbExp=3; IntAct=EBI-3957672, EBI-3916242;
CC Q6PEX3; Q03989: ARID5A; NbExp=3; IntAct=EBI-3957672, EBI-948603;
CC Q6PEX3; Q5BKX5-3: C19orf54; NbExp=3; IntAct=EBI-3957672, EBI-11976299;
CC Q6PEX3; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-3957672, EBI-3866279;
CC Q6PEX3; F6RF56: CCNJL; NbExp=3; IntAct=EBI-3957672, EBI-10177725;
CC Q6PEX3; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-3957672, EBI-12139335;
CC Q6PEX3; Q5T4B2: CERCAM; NbExp=3; IntAct=EBI-3957672, EBI-12261896;
CC Q6PEX3; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-3957672, EBI-749051;
CC Q6PEX3; P27658: COL8A1; NbExp=4; IntAct=EBI-3957672, EBI-747133;
CC Q6PEX3; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-3957672, EBI-3867333;
CC Q6PEX3; Q15038: DAZAP2; NbExp=3; IntAct=EBI-3957672, EBI-724310;
CC Q6PEX3; Q86UW9: DTX2; NbExp=3; IntAct=EBI-3957672, EBI-740376;
CC Q6PEX3; O95967: EFEMP2; NbExp=3; IntAct=EBI-3957672, EBI-743414;
CC Q6PEX3; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-3957672, EBI-12193763;
CC Q6PEX3; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-3957672, EBI-2807642;
CC Q6PEX3; Q9HBR3: GDPD5; NbExp=3; IntAct=EBI-3957672, EBI-10310206;
CC Q6PEX3; P28799: GRN; NbExp=8; IntAct=EBI-3957672, EBI-747754;
CC Q6PEX3; A0A0S2Z4Q4: HGS; NbExp=3; IntAct=EBI-3957672, EBI-16429135;
CC Q6PEX3; O14964: HGS; NbExp=3; IntAct=EBI-3957672, EBI-740220;
CC Q6PEX3; P35680: HNF1B; NbExp=3; IntAct=EBI-3957672, EBI-2798841;
CC Q6PEX3; P49639: HOXA1; NbExp=8; IntAct=EBI-3957672, EBI-740785;
CC Q6PEX3; Q02535: ID3; NbExp=3; IntAct=EBI-3957672, EBI-1387094;
CC Q6PEX3; Q5TA45: INTS11; NbExp=3; IntAct=EBI-3957672, EBI-748258;
CC Q6PEX3; O76011: KRT34; NbExp=3; IntAct=EBI-3957672, EBI-1047093;
CC Q6PEX3; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-3957672, EBI-11959885;
CC Q6PEX3; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-3957672, EBI-10172150;
CC Q6PEX3; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-3957672, EBI-10172290;
CC Q6PEX3; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-3957672, EBI-10172052;
CC Q6PEX3; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-3957672, EBI-1052037;
CC Q6PEX3; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-3957672, EBI-10210845;
CC Q6PEX3; P59991: KRTAP12-2; NbExp=6; IntAct=EBI-3957672, EBI-10176379;
CC Q6PEX3; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-3957672, EBI-11953846;
CC Q6PEX3; Q3LI70: KRTAP19-6; NbExp=3; IntAct=EBI-3957672, EBI-12805508;
CC Q6PEX3; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-3957672, EBI-10241353;
CC Q6PEX3; Q3LI59: KRTAP21-2; NbExp=3; IntAct=EBI-3957672, EBI-18395721;
CC Q6PEX3; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-3957672, EBI-9996449;
CC Q6PEX3; Q9BYR7: KRTAP3-2; NbExp=3; IntAct=EBI-3957672, EBI-751260;
CC Q6PEX3; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-3957672, EBI-739863;
CC Q6PEX3; Q9BYR5: KRTAP4-2; NbExp=6; IntAct=EBI-3957672, EBI-10172511;
CC Q6PEX3; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-3957672, EBI-11958132;
CC Q6PEX3; Q9BYR0: KRTAP4-7; NbExp=3; IntAct=EBI-3957672, EBI-10302547;
CC Q6PEX3; Q6L8G9: KRTAP5-6; NbExp=6; IntAct=EBI-3957672, EBI-10250562;
CC Q6PEX3; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-3957672, EBI-12111050;
CC Q6PEX3; Q3LI66: KRTAP6-2; NbExp=6; IntAct=EBI-3957672, EBI-11962084;
CC Q6PEX3; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-3957672, EBI-10261141;
CC Q6PEX3; Q9BYQ4: KRTAP9-2; NbExp=6; IntAct=EBI-3957672, EBI-1044640;
CC Q6PEX3; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-3957672, EBI-11958364;
CC Q6PEX3; Q14847-2: LASP1; NbExp=3; IntAct=EBI-3957672, EBI-9088686;
CC Q6PEX3; O14633: LCE2B; NbExp=3; IntAct=EBI-3957672, EBI-11478468;
CC Q6PEX3; O60336: MAPKBP1; NbExp=3; IntAct=EBI-3957672, EBI-947402;
CC Q6PEX3; P0CG21: NHLRC4; NbExp=3; IntAct=EBI-3957672, EBI-12868744;
CC Q6PEX3; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-3957672, EBI-945833;
CC Q6PEX3; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-3957672, EBI-22310682;
CC Q6PEX3; P32242: OTX1; NbExp=3; IntAct=EBI-3957672, EBI-740446;
CC Q6PEX3; P78337: PITX1; NbExp=3; IntAct=EBI-3957672, EBI-748265;
CC Q6PEX3; O15496: PLA2G10; NbExp=3; IntAct=EBI-3957672, EBI-726466;
CC Q6PEX3; Q8IYS1: PM20D2; NbExp=3; IntAct=EBI-3957672, EBI-11339910;
CC Q6PEX3; P0CG20: PRR35; NbExp=3; IntAct=EBI-3957672, EBI-11986293;
CC Q6PEX3; P25788: PSMA3; NbExp=3; IntAct=EBI-3957672, EBI-348380;
CC Q6PEX3; Q9Y272: RASD1; NbExp=3; IntAct=EBI-3957672, EBI-740818;
CC Q6PEX3; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-3957672, EBI-740343;
CC Q6PEX3; Q6P9E2: RECK; NbExp=3; IntAct=EBI-3957672, EBI-10253121;
CC Q6PEX3; Q9BQY4: RHOXF2; NbExp=3; IntAct=EBI-3957672, EBI-372094;
CC Q6PEX3; Q9H0X6: RNF208; NbExp=3; IntAct=EBI-3957672, EBI-751555;
CC Q6PEX3; Q15637: SF1; NbExp=3; IntAct=EBI-3957672, EBI-744603;
CC Q6PEX3; O15304-2: SIVA1; NbExp=3; IntAct=EBI-3957672, EBI-12372219;
CC Q6PEX3; Q16348: SLC15A2; NbExp=3; IntAct=EBI-3957672, EBI-12806032;
CC Q6PEX3; Q92922: SMARCC1; NbExp=3; IntAct=EBI-3957672, EBI-355653;
CC Q6PEX3; Q53HV7-2: SMUG1; NbExp=3; IntAct=EBI-3957672, EBI-12275818;
CC Q6PEX3; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-3957672, EBI-11959123;
CC Q6PEX3; Q7Z6I5: SPATA12; NbExp=3; IntAct=EBI-3957672, EBI-10696971;
CC Q6PEX3; O75716: STK16; NbExp=3; IntAct=EBI-3957672, EBI-749295;
CC Q6PEX3; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-3957672, EBI-8644516;
CC Q6PEX3; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-3957672, EBI-750487;
CC Q6PEX3; Q96LM6: TEX37; NbExp=3; IntAct=EBI-3957672, EBI-743976;
CC Q6PEX3; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-3957672, EBI-11952651;
CC Q6PEX3; Q92734: TFG; NbExp=3; IntAct=EBI-3957672, EBI-357061;
CC Q6PEX3; O94900: TOX; NbExp=3; IntAct=EBI-3957672, EBI-9088321;
CC Q6PEX3; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-3957672, EBI-5235829;
CC Q6PEX3; Q15645: TRIP13; NbExp=3; IntAct=EBI-3957672, EBI-358993;
CC Q6PEX3; Q15654: TRIP6; NbExp=3; IntAct=EBI-3957672, EBI-742327;
CC Q6PEX3; Q6EMK4: VASN; NbExp=3; IntAct=EBI-3957672, EBI-10249550;
CC Q6PEX3; O95231: VENTX; NbExp=3; IntAct=EBI-3957672, EBI-10191303;
CC Q6PEX3; Q9BYJ9: YTHDF1; NbExp=3; IntAct=EBI-3957672, EBI-1051237;
CC Q6PEX3; P09022: Hoxa1; Xeno; NbExp=4; IntAct=EBI-3957672, EBI-3957603;
CC Q6PEX3; P03410: tax; Xeno; NbExp=3; IntAct=EBI-3957672, EBI-9676218;
CC -!- TISSUE SPECIFICITY: Localized high up in the well differentiated
CC portion of the hair follicle cuticle (about 10-15 cell layers above the
CC apex of the dermal papilla). {ECO:0000269|PubMed:18647308}.
CC -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}.
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DR EMBL; AB096936; BAE46351.1; -; mRNA.
DR EMBL; AM941740; CAQ03502.1; -; mRNA.
DR EMBL; BC057825; AAH57825.1; -; mRNA.
DR CCDS; CCDS13588.1; -.
DR RefSeq; NP_981950.1; NM_203405.1.
DR AlphaFoldDB; Q6PEX3; -.
DR BioGRID; 132867; 93.
DR IntAct; Q6PEX3; 90.
DR MINT; Q6PEX3; -.
DR STRING; 9606.ENSP00000353742; -.
DR BioMuta; KRTAP26-1; -.
DR DMDM; 74737618; -.
DR MassIVE; Q6PEX3; -.
DR PaxDb; Q6PEX3; -.
DR PeptideAtlas; Q6PEX3; -.
DR PRIDE; Q6PEX3; -.
DR ProteomicsDB; 67085; -.
DR Antibodypedia; 76496; 33 antibodies from 9 providers.
DR DNASU; 388818; -.
DR Ensembl; ENST00000360542.5; ENSP00000353742.3; ENSG00000197683.5.
DR GeneID; 388818; -.
DR KEGG; hsa:388818; -.
DR MANE-Select; ENST00000360542.5; ENSP00000353742.3; NM_203405.2; NP_981950.1.
DR UCSC; uc002ynw.5; human.
DR CTD; 388818; -.
DR GeneCards; KRTAP26-1; -.
DR HGNC; HGNC:33760; KRTAP26-1.
DR HPA; ENSG00000197683; Tissue enriched (skin).
DR neXtProt; NX_Q6PEX3; -.
DR PharmGKB; PA162393763; -.
DR VEuPathDB; HostDB:ENSG00000197683; -.
DR eggNOG; ENOG502SVJ1; Eukaryota.
DR GeneTree; ENSGT00730000111511; -.
DR HOGENOM; CLU_1312603_0_0_1; -.
DR InParanoid; Q6PEX3; -.
DR OMA; CLAYRPQ; -.
DR OrthoDB; 1411177at2759; -.
DR PhylomeDB; Q6PEX3; -.
DR TreeFam; TF337331; -.
DR PathwayCommons; Q6PEX3; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q6PEX3; -.
DR BioGRID-ORCS; 388818; 10 hits in 1060 CRISPR screens.
DR GenomeRNAi; 388818; -.
DR Pharos; Q6PEX3; Tdark.
DR PRO; PR:Q6PEX3; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q6PEX3; protein.
DR Bgee; ENSG00000197683; Expressed in placenta and 12 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR007951; KRTAP_PMG.
DR PANTHER; PTHR19051; PTHR19051; 1.
DR Pfam; PF05287; PMG; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..210
FT /note="Keratin-associated protein 26-1"
FT /id="PRO_0000223916"
FT VARIANT 26
FT /note="S -> Y (in dbSNP:rs3804007)"
FT /id="VAR_053477"
FT VARIANT 188
FT /note="P -> T (in dbSNP:rs12483584)"
FT /id="VAR_053478"
SQ SEQUENCE 210 AA; 22554 MW; 7E4610AAF1044D6C CRC64;
MSCPNYCSGN SNSGSLRTSR HIPLTSIDLC PTSVSCGDVL YLPTSSQDHT WVTDNCQETC
GEPTSCQPVH CETGNLETSC GSSTAYYVPR PCQGSSFLPA SFFSSSCLPV SCRPQRYVSS
GCRPLRPLLN SYQPIGDCVP NAYRPQFCLS KSCQPQNLLT SGCQPSSCLA YRPQSLHVVS
SSLRPLGPLF SGCQPLTHVF STCRPSCSGL
