KR261_MOUSE
ID KR261_MOUSE Reviewed; 215 AA.
AC Q9D7N2; B9EIF2;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Keratin-associated protein 26-1 {ECO:0000312|EMBL:AAI28284.1};
GN Name=Krtap26-1 {ECO:0000312|MGI:MGI:1916783};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAB26061.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB26061.1};
RC TISSUE=Tongue {ECO:0000312|EMBL:BAB26061.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2] {ECO:0000312|EMBL:AAI28284.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the PMG family. {ECO:0000255}.
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DR EMBL; AK009086; BAB26061.1; -; mRNA.
DR EMBL; BC128283; AAI28284.1; -; mRNA.
DR EMBL; BC139410; AAI39411.1; -; mRNA.
DR EMBL; BC139411; AAI39412.1; -; mRNA.
DR CCDS; CCDS28298.1; -.
DR RefSeq; NP_081381.1; NM_027105.2.
DR AlphaFoldDB; Q9D7N2; -.
DR STRING; 10090.ENSMUSP00000093626; -.
DR PaxDb; Q9D7N2; -.
DR PRIDE; Q9D7N2; -.
DR ProteomicsDB; 265022; -.
DR Antibodypedia; 76496; 33 antibodies from 9 providers.
DR Ensembl; ENSMUST00000095934; ENSMUSP00000093626; ENSMUSG00000071471.
DR GeneID; 69533; -.
DR KEGG; mmu:69533; -.
DR UCSC; uc007zva.1; mouse.
DR CTD; 388818; -.
DR MGI; MGI:1916783; Krtap26-1.
DR VEuPathDB; HostDB:ENSMUSG00000071471; -.
DR eggNOG; ENOG502SVJ1; Eukaryota.
DR GeneTree; ENSGT00730000111511; -.
DR HOGENOM; CLU_1312603_0_0_1; -.
DR InParanoid; Q9D7N2; -.
DR OMA; CLAYRPQ; -.
DR OrthoDB; 1411177at2759; -.
DR PhylomeDB; Q9D7N2; -.
DR TreeFam; TF337331; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR BioGRID-ORCS; 69533; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q9D7N2; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q9D7N2; protein.
DR Bgee; ENSMUSG00000071471; Expressed in lip and 10 other tissues.
DR Genevisible; Q9D7N2; MM.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR007951; KRTAP_PMG.
DR PANTHER; PTHR19051; PTHR19051; 1.
DR Pfam; PF05287; PMG; 1.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..215
FT /note="Keratin-associated protein 26-1"
FT /id="PRO_0000358599"
SQ SEQUENCE 215 AA; 22448 MW; E6D645FA36C1F746 CRC64;
MASRNNCSSS GNCSSGSLRN TCHIPASSSI ALCSTNMGCG EVFCVPSSCQ DHTWFMDNCP
ETFAEPLSGQ PPSREASGFE NSCCSSTYCV PRHCQGSGYI PASSFISGSC LPASYRPVSY
VSSSCRPVSP FMNNCRPVSC VSGGYRPLPC GSNSCRPLGI VTYGCRPSGC VTYGPQTIHI
VSNSLRPLQP VCGGCQPSIP VFGTCRPSCS AQGGQ
