ID   KR271_HUMAN             Reviewed;         207 AA.
AC   Q3LI81;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Keratin-associated protein 27-1;
GN   Name=KRTAP27-1; Synonyms=KAP27.1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Hair root;
RA   Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT   "Identification of complete keratin-associated protein (KAP) gene cluster
RT   spanning 800 kb region on human chromosome 21q22.11.";
RL   Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the PMG family. {ECO:0000305}.
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DR   EMBL; AB096937; BAE46352.1; -; mRNA.
DR   CCDS; CCDS33532.1; -.
DR   RefSeq; NP_001071179.1; NM_001077711.1.
DR   AlphaFoldDB; Q3LI81; -.
DR   STRING; 9606.ENSP00000372286; -.
DR   GlyGen; Q3LI81; 2 sites, 1 O-linked glycan (2 sites).
DR   BioMuta; KRTAP27-1; -.
DR   DMDM; 121942690; -.
DR   PaxDb; Q3LI81; -.
DR   PeptideAtlas; Q3LI81; -.
DR   PRIDE; Q3LI81; -.
DR   Antibodypedia; 6608; 32 antibodies from 13 providers.
DR   DNASU; 643812; -.
DR   Ensembl; ENST00000382835.2; ENSP00000372286.2; ENSG00000206107.2.
DR   GeneID; 643812; -.
DR   KEGG; hsa:643812; -.
DR   MANE-Select; ENST00000382835.2; ENSP00000372286.2; NM_001077711.1; NP_001071179.1.
DR   UCSC; uc002ynx.1; human.
DR   CTD; 643812; -.
DR   GeneCards; KRTAP27-1; -.
DR   HGNC; HGNC:33864; KRTAP27-1.
DR   HPA; ENSG00000206107; Not detected.
DR   neXtProt; NX_Q3LI81; -.
DR   PharmGKB; PA162393770; -.
DR   VEuPathDB; HostDB:ENSG00000206107; -.
DR   eggNOG; KOG4726; Eukaryota.
DR   GeneTree; ENSGT00730000111539; -.
DR   HOGENOM; CLU_1312717_0_0_1; -.
DR   InParanoid; Q3LI81; -.
DR   OMA; STYEPTC; -.
DR   OrthoDB; 1460188at2759; -.
DR   PhylomeDB; Q3LI81; -.
DR   TreeFam; TF337331; -.
DR   PathwayCommons; Q3LI81; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   BioGRID-ORCS; 643812; 8 hits in 1056 CRISPR screens.
DR   GenomeRNAi; 643812; -.
DR   Pharos; Q3LI81; Tdark.
DR   PRO; PR:Q3LI81; -.
DR   Proteomes; UP000005640; Chromosome 21.
DR   RNAct; Q3LI81; protein.
DR   Bgee; ENSG00000206107; Expressed in adult mammalian kidney.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   InterPro; IPR007951; KRTAP_PMG.
DR   PANTHER; PTHR19051; PTHR19051; 1.
DR   Pfam; PF05287; PMG; 1.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..207
FT                   /note="Keratin-associated protein 27-1"
FT                   /id="PRO_0000307916"
FT   REGION          184..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         99
FT                   /note="A -> V (in dbSNP:rs2244485)"
FT                   /id="VAR_053479"
SQ   SEQUENCE   207 AA;  22345 MW;  094D8B31C20B7980 CRC64;
     MPHSHCHSLR SFHNAPPLSA ITHGTNPITF EDRLCLPSSF HSRTCFLDNF QETCNETTSC
     QMTNCEQDLF TDDSCVQSNC FPGVVQTTYS NSRPCERTAC QSESSSAGLA CVSQPCQSES
     TQQMGFVAQS CQPASLKGNS CPPKTSKSKN FETLERASSQ CQCQSQNPES SSCRPLVNVA
     PEPQLLESSP GVEPTCCVTG GSQLPSK