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KR411_HUMAN
ID   KR411_HUMAN             Reviewed;         195 AA.
AC   Q9BYQ6; A0AUY2;
DT   31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   03-AUG-2022, entry version 138.
DE   RecName: Full=Keratin-associated protein 4-11;
DE   AltName: Full=Keratin-associated protein 4-14;
DE   AltName: Full=Keratin-associated protein 4.11;
DE   AltName: Full=Keratin-associated protein 4.14;
DE   AltName: Full=Ultrahigh sulfur keratin-associated protein 4.14;
GN   Name=KRTAP4-11; Synonyms=KAP4.14, KRTAP4-14, KRTAP4.11, KRTAP4.14;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Scalp;
RX   PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA   Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA   Schweizer J.;
RT   "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT   associated protein genes embedded in the type I keratin gene domain on
RT   chromosome 17q12-21.";
RL   J. Biol. Chem. 276:19440-19451(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   TISSUE SPECIFICITY, POLYMORPHISM, AND VARIANT 44-CYS--SER-78 DEL.
RX   PubMed=15955084; DOI=10.1111/j.0022-202x.2005.23662.x;
RA   Kariya N., Shimomura Y., Ito M.;
RT   "Size polymorphisms in the human ultrahigh sulfur hair keratin-associated
RT   protein 4, KAP4, gene family.";
RL   J. Invest. Dermatol. 124:1111-1118(2005).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins.
CC   -!- INTERACTION:
CC       Q9BYQ6; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-10302392, EBI-10173507;
CC       Q9BYQ6; Q8NEC5: CATSPER1; NbExp=6; IntAct=EBI-10302392, EBI-744545;
CC       Q9BYQ6; Q9UGL9: CRCT1; NbExp=6; IntAct=EBI-10302392, EBI-713677;
CC       Q9BYQ6; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10302392, EBI-3867333;
CC       Q9BYQ6; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-10302392, EBI-746300;
CC       Q9BYQ6; Q08426: EHHADH; NbExp=3; IntAct=EBI-10302392, EBI-2339219;
CC       Q9BYQ6; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-10302392, EBI-744099;
CC       Q9BYQ6; Q9UM22: EPDR1; NbExp=3; IntAct=EBI-10302392, EBI-946972;
CC       Q9BYQ6; A4D161: FAM221A; NbExp=3; IntAct=EBI-10302392, EBI-11960181;
CC       Q9BYQ6; Q5HYJ3-3: FAM76B; NbExp=3; IntAct=EBI-10302392, EBI-11956087;
CC       Q9BYQ6; Q9NWN3: FBXO34; NbExp=3; IntAct=EBI-10302392, EBI-719816;
CC       Q9BYQ6; P15976-2: GATA1; NbExp=3; IntAct=EBI-10302392, EBI-9090198;
CC       Q9BYQ6; O76003: GLRX3; NbExp=8; IntAct=EBI-10302392, EBI-374781;
CC       Q9BYQ6; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-10302392, EBI-11975289;
CC       Q9BYQ6; P49639: HOXA1; NbExp=11; IntAct=EBI-10302392, EBI-740785;
CC       Q9BYQ6; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-10302392, EBI-6426443;
CC       Q9BYQ6; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10302392, EBI-11749135;
CC       Q9BYQ6; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-10302392, EBI-11741292;
CC       Q9BYQ6; P60410: KRTAP10-8; NbExp=9; IntAct=EBI-10302392, EBI-10171774;
CC       Q9BYQ6; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-10302392, EBI-10172052;
CC       Q9BYQ6; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10302392, EBI-1052037;
CC       Q9BYQ6; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-10302392, EBI-11992140;
CC       Q9BYQ6; Q9BYP8: KRTAP17-1; NbExp=5; IntAct=EBI-10302392, EBI-11988175;
CC       Q9BYQ6; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-10302392, EBI-14065470;
CC       Q9BYQ6; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-10302392, EBI-9996449;
CC       Q9BYQ6; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-10302392, EBI-3957694;
CC       Q9BYQ6; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-10302392, EBI-10250562;
CC       Q9BYQ6; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-10302392, EBI-3958099;
CC       Q9BYQ6; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-10302392, EBI-11962084;
CC       Q9BYQ6; Q9BYQ4: KRTAP9-2; NbExp=6; IntAct=EBI-10302392, EBI-1044640;
CC       Q9BYQ6; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-10302392, EBI-11958364;
CC       Q9BYQ6; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-10302392, EBI-11962058;
CC       Q9BYQ6; Q5T7P3: LCE1B; NbExp=6; IntAct=EBI-10302392, EBI-10245913;
CC       Q9BYQ6; Q5T751: LCE1C; NbExp=5; IntAct=EBI-10302392, EBI-12224199;
CC       Q9BYQ6; Q5T752: LCE1D; NbExp=5; IntAct=EBI-10302392, EBI-11741311;
CC       Q9BYQ6; Q5T753: LCE1E; NbExp=3; IntAct=EBI-10302392, EBI-11955335;
CC       Q9BYQ6; Q5T754: LCE1F; NbExp=3; IntAct=EBI-10302392, EBI-11958008;
CC       Q9BYQ6; Q5TA81: LCE2C; NbExp=8; IntAct=EBI-10302392, EBI-11973993;
CC       Q9BYQ6; Q5TA76: LCE3A; NbExp=5; IntAct=EBI-10302392, EBI-9394625;
CC       Q9BYQ6; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-10302392, EBI-11974495;
CC       Q9BYQ6; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-10302392, EBI-10245291;
CC       Q9BYQ6; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-10302392, EBI-10245456;
CC       Q9BYQ6; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-10302392, EBI-10246358;
CC       Q9BYQ6; Q5TCM9: LCE5A; NbExp=6; IntAct=EBI-10302392, EBI-11955689;
CC       Q9BYQ6; Q5T871: LELP1; NbExp=3; IntAct=EBI-10302392, EBI-18115868;
CC       Q9BYQ6; P50222: MEOX2; NbExp=3; IntAct=EBI-10302392, EBI-748397;
CC       Q9BYQ6; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10302392, EBI-16439278;
CC       Q9BYQ6; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10302392, EBI-945833;
CC       Q9BYQ6; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10302392, EBI-22310682;
CC       Q9BYQ6; Q92570: NR4A3; NbExp=3; IntAct=EBI-10302392, EBI-13644623;
CC       Q9BYQ6; Q7Z417: NUFIP2; NbExp=6; IntAct=EBI-10302392, EBI-1210753;
CC       Q9BYQ6; P32242: OTX1; NbExp=6; IntAct=EBI-10302392, EBI-740446;
CC       Q9BYQ6; P07237: P4HB; NbExp=3; IntAct=EBI-10302392, EBI-395883;
CC       Q9BYQ6; P13667: PDIA4; NbExp=3; IntAct=EBI-10302392, EBI-1054653;
CC       Q9BYQ6; O15162: PLSCR1; NbExp=3; IntAct=EBI-10302392, EBI-740019;
CC       Q9BYQ6; A0JP26: POTEB3; NbExp=3; IntAct=EBI-10302392, EBI-18165900;
CC       Q9BYQ6; Q12837: POU4F2; NbExp=3; IntAct=EBI-10302392, EBI-17236143;
CC       Q9BYQ6; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-10302392, EBI-1567797;
CC       Q9BYQ6; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-10302392, EBI-3918154;
CC       Q9BYQ6; Q9NUL5-4: SHFL; NbExp=5; IntAct=EBI-10302392, EBI-11955083;
CC       Q9BYQ6; Q9UHI7-3: SLC23A1; NbExp=3; IntAct=EBI-10302392, EBI-11998660;
CC       Q9BYQ6; P49901: SMCP; NbExp=6; IntAct=EBI-10302392, EBI-750494;
CC       Q9BYQ6; O43597: SPRY2; NbExp=3; IntAct=EBI-10302392, EBI-742487;
CC       Q9BYQ6; P01137: TGFB1; NbExp=3; IntAct=EBI-10302392, EBI-779636;
CC       Q9BYQ6; O14817: TSPAN4; NbExp=3; IntAct=EBI-10302392, EBI-8652667;
CC       Q9BYQ6; Q6EMK4: VASN; NbExp=6; IntAct=EBI-10302392, EBI-10249550;
CC       Q9BYQ6; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-10302392, EBI-11957216;
CC       Q9BYQ6; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-10302392, EBI-740727;
CC       Q9BYQ6; Q9H707: ZNF552; NbExp=6; IntAct=EBI-10302392, EBI-2555731;
CC       Q9BYQ6; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-10302392, EBI-11962574;
CC   -!- TISSUE SPECIFICITY: Expressed in the hair follicles.
CC       {ECO:0000269|PubMed:15955084}.
CC   -!- POLYMORPHISM: Numerous size polymorphism are present in KRTAP4 gene
CC       family, which are mainly due to variations in the sequence encoding
CC       cysteine-rich repeat segments (PubMed:15955084).
CC       {ECO:0000269|PubMed:15955084}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 4 family. {ECO:0000305}.
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DR   EMBL; AJ406944; CAC27583.1; -; mRNA.
DR   EMBL; AC100808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC126131; AAI26132.1; -; mRNA.
DR   EMBL; BC130562; AAI30563.1; -; mRNA.
DR   CCDS; CCDS45675.1; -.
DR   RefSeq; NP_149048.2; NM_033059.3.
DR   AlphaFoldDB; Q9BYQ6; -.
DR   BioGRID; 575632; 70.
DR   IntAct; Q9BYQ6; 71.
DR   MINT; Q9BYQ6; -.
DR   BioMuta; KRTAP4-11; -.
DR   DMDM; 296434556; -.
DR   MassIVE; Q9BYQ6; -.
DR   PaxDb; Q9BYQ6; -.
DR   PeptideAtlas; Q9BYQ6; -.
DR   PRIDE; Q9BYQ6; -.
DR   DNASU; 653240; -.
DR   Ensembl; ENST00000391413.4; ENSP00000375232.2; ENSG00000212721.4.
DR   Ensembl; ENST00000573418.2; ENSP00000460506.1; ENSG00000263229.4.
DR   GeneID; 653240; -.
DR   KEGG; hsa:653240; -.
DR   MANE-Select; ENST00000391413.4; ENSP00000375232.2; NM_033059.4; NP_149048.2.
DR   UCSC; uc002hvz.5; human.
DR   CTD; 653240; -.
DR   GeneCards; KRTAP4-11; -.
DR   HGNC; HGNC:18911; KRTAP4-11.
DR   HPA; ENSG00000212721; Tissue enriched (skin).
DR   neXtProt; NX_Q9BYQ6; -.
DR   PharmGKB; PA38759; -.
DR   VEuPathDB; HostDB:ENSG00000212721; -.
DR   eggNOG; KOG4726; Eukaryota.
DR   GeneTree; ENSGT00940000163975; -.
DR   HOGENOM; CLU_113141_2_0_1; -.
DR   InParanoid; Q9BYQ6; -.
DR   OMA; RSICARP; -.
DR   TreeFam; TF351356; -.
DR   PathwayCommons; Q9BYQ6; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   SignaLink; Q9BYQ6; -.
DR   BioGRID-ORCS; 653240; 334 hits in 985 CRISPR screens.
DR   GenomeRNAi; 653240; -.
DR   Pharos; Q9BYQ6; Tdark.
DR   PRO; PR:Q9BYQ6; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; Q9BYQ6; protein.
DR   Bgee; ENSG00000212721; Expressed in skin of abdomen and 8 other tissues.
DR   Genevisible; Q9BYQ6; HS.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 1.
DR   Pfam; PF13885; Keratin_B2_2; 3.
PE   1: Evidence at protein level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..195
FT                   /note="Keratin-associated protein 4-11"
FT                   /id="PRO_0000185180"
FT   REPEAT          5..9
FT                   /note="1"
FT   REPEAT          24..28
FT                   /note="2"
FT   REPEAT          29..33
FT                   /note="3"
FT   REPEAT          34..38
FT                   /note="4"
FT   REPEAT          44..48
FT                   /note="5"
FT   REPEAT          49..53
FT                   /note="6"
FT   REPEAT          54..58
FT                   /note="7"
FT   REPEAT          59..63
FT                   /note="8"
FT   REPEAT          64..68
FT                   /note="9"
FT   REPEAT          69..73
FT                   /note="10"
FT   REPEAT          74..78
FT                   /note="11"
FT   REPEAT          79..83
FT                   /note="12"
FT   REPEAT          84..88
FT                   /note="13"
FT   REPEAT          89..93
FT                   /note="14"
FT   REPEAT          94..98
FT                   /note="15"
FT   REPEAT          99..103
FT                   /note="16"
FT   REPEAT          104..108
FT                   /note="17"
FT   REPEAT          109..113
FT                   /note="18"
FT   REPEAT          114..118
FT                   /note="19"
FT   REPEAT          119..123
FT                   /note="20"
FT   REPEAT          124..128
FT                   /note="21"
FT   REPEAT          129..133
FT                   /note="22"
FT   REPEAT          134..138
FT                   /note="23"
FT   REPEAT          144..148
FT                   /note="24"
FT   REPEAT          149..153
FT                   /note="25"
FT   REPEAT          154..158
FT                   /note="26"
FT   REPEAT          159..163
FT                   /note="27"
FT   REGION          5..163
FT                   /note="27 X 5 AA repeats of C-C-[GIKRQVHEL]-[SPTR]-
FT                   [STVQRMC]"
FT   VARIANT         44..78
FT                   /note="Missing (in allele KAP4.14)"
FT                   /evidence="ECO:0000269|PubMed:15955084"
FT                   /id="VAR_064553"
FT   CONFLICT        17
FT                   /note="R -> Q (in Ref. 1; CAC27583 and 3; AAI26132/
FT                   AAI30563)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        167
FT                   /note="R -> G (in Ref. 1; CAC27583 and 3; AAI26132/
FT                   AAI30563)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   195 AA;  20927 MW;  99FB5C3FBB788BCA CRC64;
     MVNSCCGSVC SHQGCGRDLC QETCCRPSCC ETTCCRTTYC RPSCCVSSCC RPQCCQSVCC
     QPTCCRPRCC ISSCCRPSCC VSSCCKPQCC QSMCCQPTCC RPRCCISSCC RPSCCVSSCC
     RPQCCQSVCC QPTCCHPSCS ISSCCRPSCC ESSCCRPCCC LRPVCGRVSC HTTCYRPTCV
     ISSCPRPLCC ASSCC
 
 
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