KR510_HUMAN
ID KR510_HUMAN Reviewed; 202 AA.
AC Q6L8G5; B9EHA4;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Keratin-associated protein 5-10;
DE AltName: Full=Keratin-associated protein 5.10;
DE AltName: Full=Ultrahigh sulfur keratin-associated protein 5.10;
GN Name=KRTAP5-10; Synonyms=KAP5.10, KRTAP5.10;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Hair root;
RX PubMed=15144888; DOI=10.1016/j.bbrc.2004.04.074;
RA Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J.,
RA Shimizu N.;
RT "Identification of two novel clusters of ultrahigh-sulfur keratin-
RT associated protein genes on human chromosome 11.";
RL Biochem. Biophys. Res. Commun. 318:655-664(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated protein (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- TISSUE SPECIFICITY: Expressed in hair root but not in skin. Expressed
CC also in brain and skeletal muscle. {ECO:0000269|PubMed:15144888}.
CC -!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB126079; BAD20206.1; -; mRNA.
DR EMBL; BC137550; AAI37551.1; -; mRNA.
DR EMBL; BC137566; AAI37567.1; -; mRNA.
DR CCDS; CCDS41684.1; -.
DR RefSeq; NP_001012728.1; NM_001012710.1.
DR AlphaFoldDB; Q6L8G5; -.
DR STRING; 9606.ENSP00000381542; -.
DR iPTMnet; Q6L8G5; -.
DR PhosphoSitePlus; Q6L8G5; -.
DR BioMuta; KRTAP5-10; -.
DR PaxDb; Q6L8G5; -.
DR PeptideAtlas; Q6L8G5; -.
DR PRIDE; Q6L8G5; -.
DR Ensembl; ENST00000398531.3; ENSP00000381542.1; ENSG00000204572.10.
DR GeneID; 387273; -.
DR KEGG; hsa:387273; -.
DR MANE-Select; ENST00000398531.3; ENSP00000381542.1; NM_001012710.2; NP_001012728.1.
DR UCSC; uc001oqt.2; human.
DR CTD; 387273; -.
DR GeneCards; KRTAP5-10; -.
DR HGNC; HGNC:23605; KRTAP5-10.
DR HPA; ENSG00000204572; Tissue enhanced (epididymis, skin).
DR neXtProt; NX_Q6L8G5; -.
DR OpenTargets; ENSG00000204572; -.
DR PharmGKB; PA134898624; -.
DR VEuPathDB; HostDB:ENSG00000204572; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00990000204753; -.
DR HOGENOM; CLU_097966_0_0_1; -.
DR OMA; CWGCTGS; -.
DR PathwayCommons; Q6L8G5; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR BioGRID-ORCS; 387273; 318 hits in 991 CRISPR screens.
DR GenomeRNAi; 387273; -.
DR Pharos; Q6L8G5; Tdark.
DR PRO; PR:Q6L8G5; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6L8G5; protein.
DR Bgee; ENSG00000204572; Expressed in right uterine tube and 73 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 2.
DR Pfam; PF13885; Keratin_B2_2; 1.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..202
FT /note="Keratin-associated protein 5-10"
FT /id="PRO_0000184108"
FT REPEAT 48..51
FT /note="1"
FT REPEAT 54..57
FT /note="2"
FT REPEAT 144..147
FT /note="3"
FT REPEAT 162..165
FT /note="4"
FT REPEAT 172..175
FT /note="5"
FT REPEAT 182..185
FT /note="6"
FT REPEAT 192..195
FT /note="7"
FT REGION 48..195
FT /note="7 X 4 AA repeats of C-C-X-P"
SQ SEQUENCE 202 AA; 17984 MW; F77FF7426B976B27 CRC64;
MGCCGCSGGC GSGCGGCGSG CGGCGSGCGG YGSGCGGCGS SCCVPVCCCK PVCCCVPACS
CSSCGSCGGS KGDCGSCGGS KGGCGSCGGS KGGCGSCGGS KGGCGSCGGS KGGCGSCGGS
KGGCGSCGGS KGGCGSCGCS QCNCCKPCCC SSGCGSCCQS SCCNPCCCQS SCCVPVCCQS
SCCKPCCCQS SCCVPVCCQC KI
