KR511_HUMAN
ID KR511_HUMAN Reviewed; 156 AA.
AC Q6L8G4;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Keratin-associated protein 5-11;
DE AltName: Full=Keratin-associated protein 5.11;
DE AltName: Full=Ultrahigh sulfur keratin-associated protein 5.11;
GN Name=KRTAP5-11; Synonyms=KAP5.11, KRTAP5.11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Hair root;
RX PubMed=15144888; DOI=10.1016/j.bbrc.2004.04.074;
RA Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J.,
RA Shimizu N.;
RT "Identification of two novel clusters of ultrahigh-sulfur keratin-
RT associated protein genes on human chromosome 11.";
RL Biochem. Biophys. Res. Commun. 318:655-664(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated protein (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q6L8G4; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11993296, EBI-744545;
CC Q6L8G4; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-11993296, EBI-713677;
CC Q6L8G4; Q02930-3: CREB5; NbExp=3; IntAct=EBI-11993296, EBI-10192698;
CC Q6L8G4; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11993296, EBI-3867333;
CC Q6L8G4; Q5HYJ3-3: FAM76B; NbExp=3; IntAct=EBI-11993296, EBI-11956087;
CC Q6L8G4; O76003: GLRX3; NbExp=3; IntAct=EBI-11993296, EBI-374781;
CC Q6L8G4; Q9H8Y8: GORASP2; NbExp=5; IntAct=EBI-11993296, EBI-739467;
CC Q6L8G4; P49639: HOXA1; NbExp=5; IntAct=EBI-11993296, EBI-740785;
CC Q6L8G4; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11993296, EBI-11959885;
CC Q6L8G4; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11993296, EBI-11749135;
CC Q6L8G4; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-11993296, EBI-11741292;
CC Q6L8G4; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-11993296, EBI-12012928;
CC Q6L8G4; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11993296, EBI-10172290;
CC Q6L8G4; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11993296, EBI-10171774;
CC Q6L8G4; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11993296, EBI-10172052;
CC Q6L8G4; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11993296, EBI-1052037;
CC Q6L8G4; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-11993296, EBI-10241252;
CC Q6L8G4; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-11993296, EBI-11992140;
CC Q6L8G4; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-11993296, EBI-11988175;
CC Q6L8G4; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-11993296, EBI-14065470;
CC Q6L8G4; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11993296, EBI-11958132;
CC Q6L8G4; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-11993296, EBI-11987425;
CC Q6L8G4; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-11993296, EBI-3958099;
CC Q6L8G4; Q9BYQ4: KRTAP9-2; NbExp=5; IntAct=EBI-11993296, EBI-1044640;
CC Q6L8G4; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-11993296, EBI-1043191;
CC Q6L8G4; Q9BYQ0: KRTAP9-8; NbExp=6; IntAct=EBI-11993296, EBI-11958364;
CC Q6L8G4; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-11993296, EBI-11962058;
CC Q6L8G4; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-11993296, EBI-10245913;
CC Q6L8G4; Q5T751: LCE1C; NbExp=3; IntAct=EBI-11993296, EBI-12224199;
CC Q6L8G4; Q5T752: LCE1D; NbExp=7; IntAct=EBI-11993296, EBI-11741311;
CC Q6L8G4; Q5T753: LCE1E; NbExp=4; IntAct=EBI-11993296, EBI-11955335;
CC Q6L8G4; Q5T754: LCE1F; NbExp=3; IntAct=EBI-11993296, EBI-11958008;
CC Q6L8G4; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11993296, EBI-11973993;
CC Q6L8G4; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-11993296, EBI-9394625;
CC Q6L8G4; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-11993296, EBI-11974495;
CC Q6L8G4; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-11993296, EBI-10245291;
CC Q6L8G4; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-11993296, EBI-10245456;
CC Q6L8G4; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-11993296, EBI-10246358;
CC Q6L8G4; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-11993296, EBI-11955689;
CC Q6L8G4; Q5T871: LELP1; NbExp=3; IntAct=EBI-11993296, EBI-18115868;
CC Q6L8G4; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11993296, EBI-16439278;
CC Q6L8G4; Q9NQS3-2: NECTIN3; NbExp=3; IntAct=EBI-11993296, EBI-12106440;
CC Q6L8G4; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11993296, EBI-22310682;
CC Q6L8G4; Q92570: NR4A3; NbExp=3; IntAct=EBI-11993296, EBI-13644623;
CC Q6L8G4; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-11993296, EBI-1210753;
CC Q6L8G4; P32242: OTX1; NbExp=3; IntAct=EBI-11993296, EBI-740446;
CC Q6L8G4; Q12837: POU4F2; NbExp=3; IntAct=EBI-11993296, EBI-17236143;
CC Q6L8G4; Q9UGC6: RGS17; NbExp=5; IntAct=EBI-11993296, EBI-3918154;
CC Q6L8G4; O76081-6: RGS20; NbExp=3; IntAct=EBI-11993296, EBI-10178530;
CC Q6L8G4; Q9NR46: SH3GLB2; NbExp=3; IntAct=EBI-11993296, EBI-749607;
CC Q6L8G4; P49901: SMCP; NbExp=5; IntAct=EBI-11993296, EBI-750494;
CC Q6L8G4; Q9C004: SPRY4; NbExp=3; IntAct=EBI-11993296, EBI-354861;
CC Q6L8G4; Q8WZ59: TMEM190; NbExp=3; IntAct=EBI-11993296, EBI-10278423;
CC Q6L8G4; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-11993296, EBI-5235829;
CC Q6L8G4; Q6EMK4: VASN; NbExp=3; IntAct=EBI-11993296, EBI-10249550;
CC Q6L8G4; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-11993296, EBI-11957216;
CC -!- TISSUE SPECIFICITY: Restricted to hair root, not detected in any other
CC tissues. {ECO:0000269|PubMed:15144888}.
CC -!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}.
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DR EMBL; AB126080; BAD20207.1; -; mRNA.
DR CCDS; CCDS41685.1; -.
DR RefSeq; NP_001005405.1; NM_001005405.2.
DR AlphaFoldDB; Q6L8G4; -.
DR BioGRID; 136248; 58.
DR IntAct; Q6L8G4; 56.
DR STRING; 9606.ENSP00000381541; -.
DR iPTMnet; Q6L8G4; -.
DR PhosphoSitePlus; Q6L8G4; -.
DR BioMuta; KRTAP5-11; -.
DR MassIVE; Q6L8G4; -.
DR PaxDb; Q6L8G4; -.
DR PeptideAtlas; Q6L8G4; -.
DR PRIDE; Q6L8G4; -.
DR Antibodypedia; 77334; 1 antibodies from 1 providers.
DR DNASU; 440051; -.
DR Ensembl; ENST00000398530.1; ENSP00000381541.1; ENSG00000204571.7.
DR GeneID; 440051; -.
DR KEGG; hsa:440051; -.
DR MANE-Select; ENST00000398530.1; ENSP00000381541.1; NM_001005405.3; NP_001005405.1.
DR UCSC; uc001oqu.3; human.
DR CTD; 440051; -.
DR GeneCards; KRTAP5-11; -.
DR HGNC; HGNC:23606; KRTAP5-11.
DR HPA; ENSG00000204571; Tissue enriched (skin).
DR neXtProt; NX_Q6L8G4; -.
DR OpenTargets; ENSG00000204571; -.
DR PharmGKB; PA134989436; -.
DR VEuPathDB; HostDB:ENSG00000204571; -.
DR eggNOG; ENOG502TE7N; Eukaryota.
DR HOGENOM; CLU_097966_1_0_1; -.
DR PathwayCommons; Q6L8G4; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q6L8G4; -.
DR BioGRID-ORCS; 440051; 284 hits in 992 CRISPR screens.
DR ChiTaRS; KRTAP5-11; human.
DR GenomeRNAi; 440051; -.
DR Pharos; Q6L8G4; Tdark.
DR PRO; PR:Q6L8G4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6L8G4; protein.
DR Bgee; ENSG00000204571; Expressed in nucleus accumbens and 33 other tissues.
DR ExpressionAtlas; Q6L8G4; baseline and differential.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
DR Pfam; PF13885; Keratin_B2_2; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..156
FT /note="Keratin-associated protein 5-11"
FT /id="PRO_0000184109"
FT REPEAT 35..38
FT /note="1"
FT REPEAT 41..44
FT /note="2"
FT REPEAT 47..50
FT /note="3"
FT REPEAT 87..90
FT /note="4"
FT REPEAT 121..124
FT /note="5"
FT REPEAT 146..149
FT /note="6"
FT REGION 35..149
FT /note="6 X 4 AA repeats of C-C-X-P"
SQ SEQUENCE 156 AA; 14610 MW; 42BEF951559C0A50 CRC64;
MGCCGCSGGC GSGCGGCGSG SGGCGSGCGG CGSSCCVPIC CCKPVCCCVP ACSCSSCGSC
GGSKGGCGSC GSSKGGCGSC GCSQSNCCKP CCSSSGCGSF CCQSSCSKPC CCQSSCCQSS
CCKPCCCQSS CCQSSCFKPC CCQSSCCVPV CCQCKI
