ID   KR74_ICHVA              Reviewed;         673 AA.
AC   Q00095;
DT   01-DEC-1992, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-1992, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Protein kinase ORF74;
DE            EC=2.7.11.1;
GN   Name=ORF74;
OS   Ictalurid herpesvirus 1 (strain Auburn) (IcHV-1) (Channel catfish
OS   herpesvirus).
OC   Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC   Herpesvirales; Alloherpesviridae; Ictalurivirus.
OX   NCBI_TaxID=766178;
OH   NCBI_TaxID=7996; Ictaluridae (bullhead catfishes).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Auburn 1;
RX   PubMed=1727613; DOI=10.1016/0042-6822(92)90056-u;
RA   Davison A.J.;
RT   "Channel catfish virus: a new type of herpesvirus.";
RL   Virology 186:9-14(1992).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC         [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC         COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC         threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC         Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC         EC=2.7.11.1;
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Ser/Thr protein
CC       kinase family. {ECO:0000255|PROSITE-ProRule:PRU00159}.
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DR   EMBL; M75136; AAA88176.1; -; Genomic_DNA.
DR   PIR; I36793; TVBEI5.
DR   RefSeq; NP_041164.1; NC_001493.2.
DR   GeneID; 1488364; -.
DR   KEGG; vg:1488364; -.
DR   Proteomes; UP000007643; Genome.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0106310; F:protein serine kinase activity; IEA:RHEA.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0006468; P:protein phosphorylation; IEA:InterPro.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Kinase; Nucleotide-binding; Reference proteome;
KW   Serine/threonine-protein kinase; Transferase.
FT   CHAIN           1..673
FT                   /note="Protein kinase ORF74"
FT                   /id="PRO_0000086191"
FT   DOMAIN          128..404
FT                   /note="Protein kinase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
FT   REGION          340..364
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        252
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00159"
SQ   SEQUENCE   673 AA;  74133 MW;  C59466DA3A112FE8 CRC64;
     MSGKVEINEP LIVATSAPLR CNCTGGSHFH GKTIANRALG SSQLMKCYSG LLKRCVRREK
     YIPVSDRGFL DAYTPQTAPG IVFTGSSLVT DSTLMMAPFN FHRQHVLPLE ENFGLERARG
     DVTVDIRTDT DEAVARGLRS DMYERDAVGH IVSKPQKRTT GEMLDELMMT ARLSHGNLVR
     FLGGVACEET RGGKITVKMV ELGLCNLDEF IAEPHWIAPK FAIVRQYTLC KLERDTLSGL
     EYLHMHGVVH GDFRGAKVIV FPTADDFTFK VNLGESTSLG IAPALSRAPY HRAPETEFTG
     LIGREADMWA WALTMYRAHT CKDFFKKGDP SEPYRVLGPM DNDALDSRRT GRDGDPVNPE
     GFGTRLEKNA TAVDGGFIGL MGKCLALYPQ FRPTARELLV YPRYATLHRI SGPGPAPPPV
     IGAAPAVRVV SNAVEFRSRW GVRPSPAMDP RLEARTSWGK NAVRAVGDFT PSFLYREGGL
     GDTRPGNKRA ITLSRGTLRS YVGTENRLTT EIHRSGGADI VLHKVVGRRP DISRANLEYV
     MKVSNGFPEW YITIDHYTVG VTNVHLYVGY ITDDIVYASA IGLSCPLRVD ILKGFEKSTL
     RVDLMGILVT RGLAYTLRVI RHLKSASIYE AGPHAVGLVF VNPSSRNRFG TVSCDSVKLE
     LGDEPSQLIT GSR