KRA11_HUMAN
ID KRA11_HUMAN Reviewed; 177 AA.
AC Q07627; A6NC32; Q96S60; Q96S67;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Keratin-associated protein 1-1;
DE AltName: Full=High sulfur keratin-associated protein 1.1;
DE AltName: Full=Keratin-associated protein 1.1;
DE AltName: Full=Keratin-associated protein 1.6;
DE AltName: Full=Keratin-associated protein 1.7;
GN Name=KRTAP1-1; Synonyms=B2A, KAP1.1, KAP1.6, KAP1.7, KRTAP1.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Zhumabaeva B.D., Gening L.V., Gazaryan K.G.;
RT "Cloning and structural characterization of human hair sulfur-rich keratin
RT genes.";
RL Mol. Biol. (Mosk.) 26:550-555(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Aoki N., Shimomura Y.;
RT "Isolation of KAP1.1.";
RL Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS 12-PRO--PRO-58 DEL ARG INS AND
RP 19-THR--GLY-110 DEL.
RX PubMed=11841537; DOI=10.1046/j.0022-202x.2001.01653.x;
RA Shimomura Y., Aoki N., Rogers M.A., Langbein L., Schweizer J., Ito M.;
RT "hKAP1.6 and hKAP1.7, two novel human high sulfur keratin-associated
RT proteins are expressed in the hair follicle cortex.";
RL J. Invest. Dermatol. 118:226-231(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [8]
RP VARIANT 12-PRO--PRO-58 DEL ARG INS.
RX PubMed=12228244; DOI=10.1074/jbc.m206398200;
RA Shimomura Y., Aoki N., Schweizer J., Langbein L., Rogers M.A., Winter H.,
RA Ito M.;
RT "Polymorphisms in the human high sulfur hair keratin-associated protein 1,
RT KAP1, gene family.";
RL J. Biol. Chem. 277:45493-45501(2002).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q07627; O43184-4: ADAM12; NbExp=3; IntAct=EBI-11959885, EBI-12006944;
CC Q07627; P82987: ADAMTSL3; NbExp=3; IntAct=EBI-11959885, EBI-10221726;
CC Q07627; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11959885, EBI-10173507;
CC Q07627; P21549: AGXT; NbExp=3; IntAct=EBI-11959885, EBI-727098;
CC Q07627; O95154: AKR7A3; NbExp=3; IntAct=EBI-11959885, EBI-748869;
CC Q07627; P43353: ALDH3B1; NbExp=3; IntAct=EBI-11959885, EBI-2558314;
CC Q07627; P05187: ALPP; NbExp=3; IntAct=EBI-11959885, EBI-1211484;
CC Q07627; P29972: AQP1; NbExp=3; IntAct=EBI-11959885, EBI-745213;
CC Q07627; Q9BZE9: ASPSCR1; NbExp=3; IntAct=EBI-11959885, EBI-1993677;
CC Q07627; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-11959885, EBI-12006308;
CC Q07627; P50895: BCAM; NbExp=3; IntAct=EBI-11959885, EBI-10212133;
CC Q07627; Q5T681: C10orf62; NbExp=3; IntAct=EBI-11959885, EBI-744052;
CC Q07627; Q6NUJ2: C11orf87; NbExp=3; IntAct=EBI-11959885, EBI-6660291;
CC Q07627; Q13554-3: CAMK2B; NbExp=3; IntAct=EBI-11959885, EBI-11523526;
CC Q07627; Q7Z7H3: CATIP; NbExp=3; IntAct=EBI-11959885, EBI-10258233;
CC Q07627; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11959885, EBI-744545;
CC Q07627; Q6UXG3: CD300LG; NbExp=3; IntAct=EBI-11959885, EBI-10254587;
CC Q07627; Q8TCT0: CERK; NbExp=3; IntAct=EBI-11959885, EBI-10274247;
CC Q07627; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-11959885, EBI-741528;
CC Q07627; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-11959885, EBI-947551;
CC Q07627; P07510-2: CHRNG; NbExp=3; IntAct=EBI-11959885, EBI-11979451;
CC Q07627; P57739: CLDN2; NbExp=3; IntAct=EBI-11959885, EBI-751440;
CC Q07627; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-11959885, EBI-741032;
CC Q07627; Q49AN0: CRY2; NbExp=3; IntAct=EBI-11959885, EBI-2212355;
CC Q07627; P09603: CSF1; NbExp=3; IntAct=EBI-11959885, EBI-2872294;
CC Q07627; P09228: CST2; NbExp=3; IntAct=EBI-11959885, EBI-8832659;
CC Q07627; Q99895: CTRC; NbExp=3; IntAct=EBI-11959885, EBI-10295404;
CC Q07627; Q9UBR2: CTSZ; NbExp=3; IntAct=EBI-11959885, EBI-8636823;
CC Q07627; Q6ZMK1-3: CYHR1; NbExp=3; IntAct=EBI-11959885, EBI-11997340;
CC Q07627; Q9NS75: CYSLTR2; NbExp=3; IntAct=EBI-11959885, EBI-3843579;
CC Q07627; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11959885, EBI-3867333;
CC Q07627; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-11959885, EBI-746300;
CC Q07627; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11959885, EBI-9679045;
CC Q07627; Q92608: DOCK2; NbExp=3; IntAct=EBI-11959885, EBI-448771;
CC Q07627; P52797: EFNA3; NbExp=3; IntAct=EBI-11959885, EBI-722730;
CC Q07627; Q9NPA0: EMC7; NbExp=3; IntAct=EBI-11959885, EBI-6309137;
CC Q07627; A4D161: FAM221A; NbExp=3; IntAct=EBI-11959885, EBI-11960181;
CC Q07627; Q8NEG0: FAM71C; NbExp=3; IntAct=EBI-11959885, EBI-752049;
CC Q07627; Q5HYJ3-3: FAM76B; NbExp=3; IntAct=EBI-11959885, EBI-11956087;
CC Q07627; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-11959885, EBI-6658203;
CC Q07627; O95363: FARS2; NbExp=3; IntAct=EBI-11959885, EBI-2513774;
CC Q07627; A0PJY2: FEZF1; NbExp=3; IntAct=EBI-11959885, EBI-11988727;
CC Q07627; P68106-2: FKBP1B; NbExp=3; IntAct=EBI-11959885, EBI-11998976;
CC Q07627; Q6VB84: FOXD4L3; NbExp=3; IntAct=EBI-11959885, EBI-11961494;
CC Q07627; O43559: FRS3; NbExp=3; IntAct=EBI-11959885, EBI-725515;
CC Q07627; Q9ULW2: FZD10; NbExp=3; IntAct=EBI-11959885, EBI-8803802;
CC Q07627; P43220: GLP1R; NbExp=3; IntAct=EBI-11959885, EBI-7466542;
CC Q07627; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-11959885, EBI-11975289;
CC Q07627; P28799: GRN; NbExp=3; IntAct=EBI-11959885, EBI-747754;
CC Q07627; P09211: GSTP1; NbExp=3; IntAct=EBI-11959885, EBI-353467;
CC Q07627; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-11959885, EBI-11978177;
CC Q07627; P08631-2: HCK; NbExp=3; IntAct=EBI-11959885, EBI-9834454;
CC Q07627; Q9UBP5: HEY2; NbExp=3; IntAct=EBI-11959885, EBI-750630;
CC Q07627; A8MVS5: HIDE1; NbExp=3; IntAct=EBI-11959885, EBI-12168227;
CC Q07627; P49639: HOXA1; NbExp=3; IntAct=EBI-11959885, EBI-740785;
CC Q07627; P09067: HOXB5; NbExp=3; IntAct=EBI-11959885, EBI-3893317;
CC Q07627; P17482: HOXB9; NbExp=3; IntAct=EBI-11959885, EBI-745290;
CC Q07627; P31273: HOXC8; NbExp=3; IntAct=EBI-11959885, EBI-1752118;
CC Q07627; P37235: HPCAL1; NbExp=3; IntAct=EBI-11959885, EBI-749311;
CC Q07627; O75506: HSBP1; NbExp=3; IntAct=EBI-11959885, EBI-748664;
CC Q07627; Q12891: HYAL2; NbExp=3; IntAct=EBI-11959885, EBI-2806068;
CC Q07627; Q6IBB0: IFITM2; NbExp=3; IntAct=EBI-11959885, EBI-12167419;
CC Q07627; Q969P0: IGSF8; NbExp=3; IntAct=EBI-11959885, EBI-8293590;
CC Q07627; Q14005-2: IL16; NbExp=4; IntAct=EBI-11959885, EBI-17178971;
CC Q07627; P01308: INS; NbExp=3; IntAct=EBI-11959885, EBI-7090529;
CC Q07627; P16144-2: ITGB4; NbExp=3; IntAct=EBI-11959885, EBI-11051601;
CC Q07627; P18084: ITGB5; NbExp=3; IntAct=EBI-11959885, EBI-1223434;
CC Q07627; Q15040: JOSD1; NbExp=3; IntAct=EBI-11959885, EBI-2510602;
CC Q07627; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-11959885, EBI-6426443;
CC Q07627; O60259: KLK8; NbExp=3; IntAct=EBI-11959885, EBI-3915857;
CC Q07627; P35900: KRT20; NbExp=3; IntAct=EBI-11959885, EBI-742094;
CC Q07627; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-11959885, EBI-10217483;
CC Q07627; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11959885, EBI-10171774;
CC Q07627; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11959885, EBI-10172052;
CC Q07627; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-11959885, EBI-10210845;
CC Q07627; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11959885, EBI-11953334;
CC Q07627; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-11959885, EBI-11953846;
CC Q07627; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-11959885, EBI-14065470;
CC Q07627; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-11959885, EBI-3957672;
CC Q07627; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-11959885, EBI-739863;
CC Q07627; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-11959885, EBI-11993254;
CC Q07627; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-11959885, EBI-11993296;
CC Q07627; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-11959885, EBI-11963072;
CC Q07627; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-11959885, EBI-10250562;
CC Q07627; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11959885, EBI-1044640;
CC Q07627; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-11959885, EBI-1043191;
CC Q07627; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-11959885, EBI-11958364;
CC Q07627; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-11959885, EBI-11962058;
CC Q07627; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11959885, EBI-11955335;
CC Q07627; Q5T754: LCE1F; NbExp=3; IntAct=EBI-11959885, EBI-11958008;
CC Q07627; O14633: LCE2B; NbExp=3; IntAct=EBI-11959885, EBI-11478468;
CC Q07627; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11959885, EBI-11973993;
CC Q07627; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11959885, EBI-10246750;
CC Q07627; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-11959885, EBI-11974495;
CC Q07627; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-11959885, EBI-10245291;
CC Q07627; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-11959885, EBI-6658837;
CC Q07627; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-11959885, EBI-10245456;
CC Q07627; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-11959885, EBI-10246358;
CC Q07627; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-11959885, EBI-11955689;
CC Q07627; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-11959885, EBI-739832;
CC Q07627; Q6PJG9: LRFN4; NbExp=3; IntAct=EBI-11959885, EBI-7910762;
CC Q07627; Q8WUT4: LRRN4; NbExp=3; IntAct=EBI-11959885, EBI-745046;
CC Q07627; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-11959885, EBI-746778;
CC Q07627; O60336: MAPKBP1; NbExp=3; IntAct=EBI-11959885, EBI-947402;
CC Q07627; P08582-2: MELTF; NbExp=3; IntAct=EBI-11959885, EBI-10195914;
CC Q07627; Q9NV56: MRGBP; NbExp=3; IntAct=EBI-11959885, EBI-399076;
CC Q07627; Q16540: MRPL23; NbExp=3; IntAct=EBI-11959885, EBI-1046141;
CC Q07627; P07438: MT1B; NbExp=3; IntAct=EBI-11959885, EBI-12015462;
CC Q07627; Q9BW11: MXD3; NbExp=3; IntAct=EBI-11959885, EBI-741574;
CC Q07627; P50539-3: MXI1; NbExp=3; IntAct=EBI-11959885, EBI-10211940;
CC Q07627; P52179-2: MYOM1; NbExp=3; IntAct=EBI-11959885, EBI-12010196;
CC Q07627; Q92692-2: NECTIN2; NbExp=3; IntAct=EBI-11959885, EBI-6979889;
CC Q07627; Q9NQS3-2: NECTIN3; NbExp=3; IntAct=EBI-11959885, EBI-12106440;
CC Q07627; P48645: NMU; NbExp=3; IntAct=EBI-11959885, EBI-10210351;
CC Q07627; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-11959885, EBI-748927;
CC Q07627; Q6NSM0: NR1D2; NbExp=3; IntAct=EBI-11959885, EBI-10250949;
CC Q07627; Q9P121-3: NTM; NbExp=3; IntAct=EBI-11959885, EBI-12027160;
CC Q07627; Q9Y5Y2: NUBP2; NbExp=3; IntAct=EBI-11959885, EBI-1048886;
CC Q07627; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-11959885, EBI-10225049;
CC Q07627; A6ND48: OR14I1; NbExp=3; IntAct=EBI-11959885, EBI-13413682;
CC Q07627; P32242: OTX1; NbExp=3; IntAct=EBI-11959885, EBI-740446;
CC Q07627; Q99571: P2RX4; NbExp=3; IntAct=EBI-11959885, EBI-2828248;
CC Q07627; Q15077: P2RY6; NbExp=3; IntAct=EBI-11959885, EBI-10235794;
CC Q07627; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-11959885, EBI-11956269;
CC Q07627; O76083-2: PDE9A; NbExp=3; IntAct=EBI-11959885, EBI-11524542;
CC Q07627; Q9HCN3: PGAP6; NbExp=3; IntAct=EBI-11959885, EBI-10310808;
CC Q07627; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-11959885, EBI-14084211;
CC Q07627; O43741: PRKAB2; NbExp=3; IntAct=EBI-11959885, EBI-1053424;
CC Q07627; P54619: PRKAG1; NbExp=3; IntAct=EBI-11959885, EBI-1181439;
CC Q07627; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-11959885, EBI-1567797;
CC Q07627; P25786: PSMA1; NbExp=3; IntAct=EBI-11959885, EBI-359352;
CC Q07627; P15151: PVR; NbExp=3; IntAct=EBI-11959885, EBI-3919694;
CC Q07627; Q15274: QPRT; NbExp=3; IntAct=EBI-11959885, EBI-739851;
CC Q07627; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-11959885, EBI-948428;
CC Q07627; Q8IYK8: REM2; NbExp=3; IntAct=EBI-11959885, EBI-11304833;
CC Q07627; Q86WX3: RPS19BP1; NbExp=3; IntAct=EBI-11959885, EBI-4479407;
CC Q07627; P62857: RPS28; NbExp=3; IntAct=EBI-11959885, EBI-353027;
CC Q07627; Q6P087: RPUSD3; NbExp=3; IntAct=EBI-11959885, EBI-5458784;
CC Q07627; Q86UN2: RTN4RL1; NbExp=3; IntAct=EBI-11959885, EBI-10258951;
CC Q07627; Q14162: SCARF1; NbExp=3; IntAct=EBI-11959885, EBI-12056025;
CC Q07627; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-11959885, EBI-748391;
CC Q07627; A0A0S2Z4U3: SDC3; NbExp=3; IntAct=EBI-11959885, EBI-10204280;
CC Q07627; Q13214-2: SEMA3B; NbExp=3; IntAct=EBI-11959885, EBI-11017428;
CC Q07627; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-11959885, EBI-11955083;
CC Q07627; Q9UHI7-3: SLC23A1; NbExp=3; IntAct=EBI-11959885, EBI-11998660;
CC Q07627; Q8N370: SLC43A2; NbExp=3; IntAct=EBI-11959885, EBI-10265149;
CC Q07627; Q9NP91: SLC6A20; NbExp=3; IntAct=EBI-11959885, EBI-10311198;
CC Q07627; Q9UPY5: SLC7A11; NbExp=3; IntAct=EBI-11959885, EBI-3843348;
CC Q07627; O75093: SLIT1; NbExp=3; IntAct=EBI-11959885, EBI-947791;
CC Q07627; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-11959885, EBI-455078;
CC Q07627; P49901: SMCP; NbExp=3; IntAct=EBI-11959885, EBI-750494;
CC Q07627; Q9H4F8-2: SMOC1; NbExp=3; IntAct=EBI-11959885, EBI-12162539;
CC Q07627; O95863: SNAI1; NbExp=3; IntAct=EBI-11959885, EBI-1045459;
CC Q07627; Q96RF0: SNX18; NbExp=3; IntAct=EBI-11959885, EBI-298169;
CC Q07627; Q96E40: SPACA9; NbExp=3; IntAct=EBI-11959885, EBI-722584;
CC Q07627; O43609: SPRY1; NbExp=3; IntAct=EBI-11959885, EBI-3866665;
CC Q07627; O75716: STK16; NbExp=3; IntAct=EBI-11959885, EBI-749295;
CC Q07627; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-11959885, EBI-11955057;
CC Q07627; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-11959885, EBI-11952651;
CC Q07627; P01137: TGFB1; NbExp=3; IntAct=EBI-11959885, EBI-779636;
CC Q07627; Q05952: TNP2; NbExp=3; IntAct=EBI-11959885, EBI-12039775;
CC Q07627; P43897: TSFM; NbExp=3; IntAct=EBI-11959885, EBI-1049298;
CC Q07627; Q6EMK4: VASN; NbExp=3; IntAct=EBI-11959885, EBI-10249550;
CC Q07627; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-11959885, EBI-11957216;
CC Q07627; Q8IW00: VSTM4; NbExp=3; IntAct=EBI-11959885, EBI-4311759;
CC Q07627; O96014: WNT11; NbExp=3; IntAct=EBI-11959885, EBI-8058160;
CC Q07627; P10074: ZBTB48; NbExp=3; IntAct=EBI-11959885, EBI-744864;
CC Q07627; Q96C00: ZBTB9; NbExp=3; IntAct=EBI-11959885, EBI-395708;
CC Q07627; Q8WTX9: ZDHHC1; NbExp=3; IntAct=EBI-11959885, EBI-2818796;
CC Q07627; Q15973: ZNF124; NbExp=3; IntAct=EBI-11959885, EBI-2555767;
CC Q07627; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-11959885, EBI-373456;
CC Q07627; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-11959885, EBI-347633;
CC Q07627; Q8NDP4: ZNF439; NbExp=3; IntAct=EBI-11959885, EBI-747580;
CC Q07627; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-11959885, EBI-726439;
CC Q07627; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-11959885, EBI-740232;
CC Q07627; Q8N8L2: ZNF491; NbExp=3; IntAct=EBI-11959885, EBI-12019860;
CC Q07627; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-11959885, EBI-10486136;
CC Q07627; Q96C55: ZNF524; NbExp=3; IntAct=EBI-11959885, EBI-10283126;
CC Q07627; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-11959885, EBI-745520;
CC Q07627; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-11959885, EBI-6427977;
CC Q07627; Q5T619: ZNF648; NbExp=3; IntAct=EBI-11959885, EBI-11985915;
CC Q07627; Q96BR6: ZNF669; NbExp=3; IntAct=EBI-11959885, EBI-12006574;
CC Q07627; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-11959885, EBI-11090299;
CC Q07627; Q8N393: ZNF786; NbExp=3; IntAct=EBI-11959885, EBI-10265203;
CC Q07627; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11959885, EBI-11962574;
CC -!- TISSUE SPECIFICITY: Expressed in the middle/upper portions of the hair
CC cortex, in the region termed the keratogenous zone.
CC {ECO:0000269|PubMed:11279113}.
CC -!- SIMILARITY: Belongs to the KRTAP type 1 family. {ECO:0000305}.
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DR EMBL; X63337; CAA44937.1; -; Genomic_DNA.
DR EMBL; AJ406926; CAC27565.1; -; mRNA.
DR EMBL; AB052934; BAB61026.1; -; mRNA.
DR EMBL; AB052868; BAB61024.1; -; mRNA.
DR EMBL; AB055057; BAB61031.1; -; mRNA.
DR EMBL; AC007455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471152; EAW60699.1; -; Genomic_DNA.
DR EMBL; BC105069; AAI05070.1; -; mRNA.
DR EMBL; BC105071; AAI05072.1; -; mRNA.
DR CCDS; CCDS42324.1; -.
DR PIR; S37650; S37650.
DR RefSeq; NP_112229.1; NM_030967.2.
DR AlphaFoldDB; Q07627; -.
DR BioGRID; 123602; 189.
DR IntAct; Q07627; 185.
DR STRING; 9606.ENSP00000305975; -.
DR BioMuta; KRTAP1-1; -.
DR DMDM; 74722292; -.
DR MassIVE; Q07627; -.
DR PaxDb; Q07627; -.
DR PeptideAtlas; Q07627; -.
DR PRIDE; Q07627; -.
DR ProteomicsDB; 58521; -.
DR Antibodypedia; 55337; 47 antibodies from 7 providers.
DR DNASU; 81851; -.
DR Ensembl; ENST00000306271.5; ENSP00000305975.4; ENSG00000188581.9.
DR Ensembl; ENST00000573871.1; ENSP00000460787.1; ENSG00000262808.2.
DR GeneID; 81851; -.
DR KEGG; hsa:81851; -.
DR MANE-Select; ENST00000306271.5; ENSP00000305975.4; NM_030967.3; NP_112229.1.
DR UCSC; uc032fzn.1; human.
DR CTD; 81851; -.
DR DisGeNET; 81851; -.
DR GeneCards; KRTAP1-1; -.
DR HGNC; HGNC:16772; KRTAP1-1.
DR HPA; ENSG00000188581; Tissue enriched (skin).
DR MIM; 608819; gene.
DR neXtProt; NX_Q07627; -.
DR OpenTargets; ENSG00000188581; -.
DR PharmGKB; PA38412; -.
DR VEuPathDB; HostDB:ENSG00000188581; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000160443; -.
DR HOGENOM; CLU_109417_0_0_1; -.
DR InParanoid; Q07627; -.
DR OMA; MACCSTN; -.
DR PhylomeDB; Q07627; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; Q07627; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q07627; -.
DR BioGRID-ORCS; 81851; 10 hits in 994 CRISPR screens.
DR GenomeRNAi; 81851; -.
DR Pharos; Q07627; Tdark.
DR PRO; PR:Q07627; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q07627; protein.
DR Bgee; ENSG00000188581; Expressed in skin of abdomen and 45 other tissues.
DR Genevisible; Q07627; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 3.
DR Pfam; PF01500; Keratin_B2; 2.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..177
FT /note="Keratin-associated protein 1-1"
FT /id="PRO_0000223901"
FT VARIANT 12..58
FT /note="PSCSTSGTCGSSCCQPSCCETSSCQPRCCETSCCQPSCCQTSFCGFP -> R
FT (in allele KAP1.6)"
FT /id="VAR_025348"
FT VARIANT 19..110
FT /note="Missing (in allele KAP1.7)"
FT /evidence="ECO:0000269|PubMed:11841537"
FT /id="VAR_025353"
SQ SEQUENCE 177 AA; 18235 MW; 8CD3613D3DFC3C79 CRC64;
MACCQTSFCG FPSCSTSGTC GSSCCQPSCC ETSSCQPRCC ETSCCQPSCC QTSFCGFPSF
STGGTCDSSC CQPSCCETSC CQPSCYQTSS CGTGCGIGGG IGYGQEGSSG AVSTRIRWCR
PDCRVEGTCL PPCCVVSCTP PSCCQLHHAE ASCCRPSYCG QSCCRPVCCC YCSEPTC
