KRA13_HUMAN
ID KRA13_HUMAN Reviewed; 167 AA.
AC Q8IUG1; Q07628; Q8IUG0; Q9BYS2;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 29-SEP-2021, sequence version 2.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Keratin-associated protein 1-3;
DE AltName: Full=Keratin-associated protein 1.8;
DE AltName: Full=Keratin-associated protein 1.9;
GN Name=KRTAP1-3;
GN Synonyms=B2B, KAP1.2, KAP1.3, KAP1.8, KAP1.9, KRATP1.9, KRTAP1.8;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT
RP GLU-THR-SER-CYS-CYS-GLN-PRO-SER-CYS-CYS-40 INS.
RX PubMed=1279380;
RA Zhumabaeva B.D., Gening L.V., Gazarian K.G.;
RT "[Cloning and structural characteristics of human hair keratin genes rich
RT in sulfur].";
RL Mol. Biol. (Mosk.) 26:813-820(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANTS SER-34;
RP GLU-THR-SER-CYS-CYS-GLN-PRO-SER-CYS-CYS-40 INS; 41-GLN--CYS-66 DEL AND
RP ARG-82.
RC TISSUE=Scalp;
RX PubMed=12228244; DOI=10.1074/jbc.m206398200;
RA Shimomura Y., Aoki N., Schweizer J., Langbein L., Rogers M.A., Winter H.,
RA Ito M.;
RT "Polymorphisms in the human high sulfur hair keratin-associated protein 1,
RT KAP1, gene family.";
RL J. Biol. Chem. 277:45493-45501(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT
RP GLU-THR-SER-CYS-CYS-GLN-PRO-SER-CYS-CYS-40 INS.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8IUG1; O43184-4: ADAM12; NbExp=3; IntAct=EBI-11749135, EBI-12006944;
CC Q8IUG1; P20933: AGA; NbExp=3; IntAct=EBI-11749135, EBI-1223922;
CC Q8IUG1; P43353: ALDH3B1; NbExp=3; IntAct=EBI-11749135, EBI-2558314;
CC Q8IUG1; P05187: ALPP; NbExp=3; IntAct=EBI-11749135, EBI-1211484;
CC Q8IUG1; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-11749135, EBI-12006308;
CC Q8IUG1; P50895: BCAM; NbExp=3; IntAct=EBI-11749135, EBI-10212133;
CC Q8IUG1; O14503: BHLHE40; NbExp=3; IntAct=EBI-11749135, EBI-711810;
CC Q8IUG1; P18075: BMP7; NbExp=3; IntAct=EBI-11749135, EBI-1035195;
CC Q8IUG1; P35070: BTC; NbExp=3; IntAct=EBI-11749135, EBI-6590057;
CC Q8IUG1; Q9UFG5: C19orf25; NbExp=3; IntAct=EBI-11749135, EBI-741214;
CC Q8IUG1; Q2NKX9: C2orf68; NbExp=3; IntAct=EBI-11749135, EBI-11603468;
CC Q8IUG1; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11749135, EBI-744545;
CC Q8IUG1; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-11749135, EBI-12139335;
CC Q8IUG1; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-11749135, EBI-741528;
CC Q8IUG1; Q9H2X0: CHRD; NbExp=3; IntAct=EBI-11749135, EBI-947551;
CC Q8IUG1; P07510-2: CHRNG; NbExp=3; IntAct=EBI-11749135, EBI-11979451;
CC Q8IUG1; P57739: CLDN2; NbExp=3; IntAct=EBI-11749135, EBI-751440;
CC Q8IUG1; Q8IZV2: CMTM8; NbExp=3; IntAct=EBI-11749135, EBI-7868911;
CC Q8IUG1; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-11749135, EBI-741032;
CC Q8IUG1; Q86WW8: COA5; NbExp=3; IntAct=EBI-11749135, EBI-5458774;
CC Q8IUG1; P27658: COL8A1; NbExp=3; IntAct=EBI-11749135, EBI-747133;
CC Q8IUG1; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-11749135, EBI-713677;
CC Q8IUG1; Q02930-3: CREB5; NbExp=5; IntAct=EBI-11749135, EBI-10192698;
CC Q8IUG1; P06850: CRH; NbExp=3; IntAct=EBI-11749135, EBI-3870390;
CC Q8IUG1; Q49AN0: CRY2; NbExp=3; IntAct=EBI-11749135, EBI-2212355;
CC Q8IUG1; Q9NSA3: CTNNBIP1; NbExp=3; IntAct=EBI-11749135, EBI-747082;
CC Q8IUG1; Q6ZMK1-3: CYHR1; NbExp=3; IntAct=EBI-11749135, EBI-11997340;
CC Q8IUG1; Q08AG9: CYP21A2; NbExp=3; IntAct=EBI-11749135, EBI-14156412;
CC Q8IUG1; A8MQ03: CYSRT1; NbExp=7; IntAct=EBI-11749135, EBI-3867333;
CC Q8IUG1; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-11749135, EBI-746300;
CC Q8IUG1; O95886: DLGAP3; NbExp=3; IntAct=EBI-11749135, EBI-1752541;
CC Q8IUG1; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11749135, EBI-9679045;
CC Q8IUG1; Q92608: DOCK2; NbExp=3; IntAct=EBI-11749135, EBI-448771;
CC Q8IUG1; P42892: ECE1; NbExp=3; IntAct=EBI-11749135, EBI-2859983;
CC Q8IUG1; Q969U6: FBXW5; NbExp=3; IntAct=EBI-11749135, EBI-741068;
CC Q8IUG1; P43220: GLP1R; NbExp=3; IntAct=EBI-11749135, EBI-7466542;
CC Q8IUG1; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-11749135, EBI-11975289;
CC Q8IUG1; P09211: GSTP1; NbExp=3; IntAct=EBI-11749135, EBI-353467;
CC Q8IUG1; P08631-2: HCK; NbExp=3; IntAct=EBI-11749135, EBI-9834454;
CC Q8IUG1; Q03014: HHEX; NbExp=3; IntAct=EBI-11749135, EBI-747421;
CC Q8IUG1; Q96JK4-2: HHIPL1; NbExp=3; IntAct=EBI-11749135, EBI-12083878;
CC Q8IUG1; P49639: HOXA1; NbExp=5; IntAct=EBI-11749135, EBI-740785;
CC Q8IUG1; P17482: HOXB9; NbExp=3; IntAct=EBI-11749135, EBI-745290;
CC Q8IUG1; P31273: HOXC8; NbExp=3; IntAct=EBI-11749135, EBI-1752118;
CC Q8IUG1; P37235: HPCAL1; NbExp=3; IntAct=EBI-11749135, EBI-749311;
CC Q8IUG1; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-11749135, EBI-3918847;
CC Q8IUG1; Q969P0: IGSF8; NbExp=3; IntAct=EBI-11749135, EBI-8293590;
CC Q8IUG1; P22301: IL10; NbExp=3; IntAct=EBI-11749135, EBI-1031632;
CC Q8IUG1; Q14005-2: IL16; NbExp=3; IntAct=EBI-11749135, EBI-17178971;
CC Q8IUG1; Q92835-2: INPP5D; NbExp=3; IntAct=EBI-11749135, EBI-9092209;
CC Q8IUG1; P01308: INS; NbExp=3; IntAct=EBI-11749135, EBI-7090529;
CC Q8IUG1; P16144-2: ITGB4; NbExp=3; IntAct=EBI-11749135, EBI-11051601;
CC Q8IUG1; P18084: ITGB5; NbExp=3; IntAct=EBI-11749135, EBI-1223434;
CC Q8IUG1; Q15040: JOSD1; NbExp=3; IntAct=EBI-11749135, EBI-2510602;
CC Q8IUG1; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-11749135, EBI-6426443;
CC Q8IUG1; Q5T749: KPRP; NbExp=3; IntAct=EBI-11749135, EBI-10981970;
CC Q8IUG1; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-11749135, EBI-10217483;
CC Q8IUG1; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-11749135, EBI-10172150;
CC Q8IUG1; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11749135, EBI-10171774;
CC Q8IUG1; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-11749135, EBI-10172052;
CC Q8IUG1; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-11749135, EBI-10210845;
CC Q8IUG1; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-11749135, EBI-10302392;
CC Q8IUG1; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-11749135, EBI-739863;
CC Q8IUG1; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-11749135, EBI-10172511;
CC Q8IUG1; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11749135, EBI-11958132;
CC Q8IUG1; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-11749135, EBI-11993254;
CC Q8IUG1; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-11749135, EBI-11993296;
CC Q8IUG1; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-11749135, EBI-11974251;
CC Q8IUG1; Q6L8H1: KRTAP5-4; NbExp=3; IntAct=EBI-11749135, EBI-11963072;
CC Q8IUG1; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-11749135, EBI-10250562;
CC Q8IUG1; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-11749135, EBI-3958099;
CC Q8IUG1; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11749135, EBI-1044640;
CC Q8IUG1; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-11749135, EBI-1043191;
CC Q8IUG1; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-11749135, EBI-11958364;
CC Q8IUG1; Q5T7P2: LCE1A; NbExp=5; IntAct=EBI-11749135, EBI-11962058;
CC Q8IUG1; Q5T7P3: LCE1B; NbExp=5; IntAct=EBI-11749135, EBI-10245913;
CC Q8IUG1; Q5T752: LCE1D; NbExp=3; IntAct=EBI-11749135, EBI-11741311;
CC Q8IUG1; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11749135, EBI-11955335;
CC Q8IUG1; Q5T754: LCE1F; NbExp=3; IntAct=EBI-11749135, EBI-11958008;
CC Q8IUG1; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-11749135, EBI-10246607;
CC Q8IUG1; O14633: LCE2B; NbExp=3; IntAct=EBI-11749135, EBI-11478468;
CC Q8IUG1; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11749135, EBI-11973993;
CC Q8IUG1; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11749135, EBI-10246750;
CC Q8IUG1; Q5TA76: LCE3A; NbExp=5; IntAct=EBI-11749135, EBI-9394625;
CC Q8IUG1; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-11749135, EBI-11974495;
CC Q8IUG1; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-11749135, EBI-10245291;
CC Q8IUG1; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-11749135, EBI-6658837;
CC Q8IUG1; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-11749135, EBI-10245456;
CC Q8IUG1; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-11749135, EBI-10246358;
CC Q8IUG1; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-11749135, EBI-11955689;
CC Q8IUG1; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-11749135, EBI-2341787;
CC Q8IUG1; Q6PJG9: LRFN4; NbExp=3; IntAct=EBI-11749135, EBI-7910762;
CC Q8IUG1; O60336: MAPKBP1; NbExp=3; IntAct=EBI-11749135, EBI-947402;
CC Q8IUG1; P00540: MOS; NbExp=3; IntAct=EBI-11749135, EBI-1757866;
CC Q8IUG1; P48039: MTNR1A; NbExp=3; IntAct=EBI-11749135, EBI-1188238;
CC Q8IUG1; Q9BW11: MXD3; NbExp=3; IntAct=EBI-11749135, EBI-741574;
CC Q8IUG1; P50539-3: MXI1; NbExp=3; IntAct=EBI-11749135, EBI-10211940;
CC Q8IUG1; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-11749135, EBI-2858213;
CC Q8IUG1; Q8IW45: NAXD; NbExp=3; IntAct=EBI-11749135, EBI-8650724;
CC Q8IUG1; Q92692-2: NECTIN2; NbExp=3; IntAct=EBI-11749135, EBI-6979889;
CC Q8IUG1; Q9NQS3-2: NECTIN3; NbExp=3; IntAct=EBI-11749135, EBI-12106440;
CC Q8IUG1; Q8IV28: NID2; NbExp=3; IntAct=EBI-11749135, EBI-10261509;
CC Q8IUG1; P48645: NMU; NbExp=3; IntAct=EBI-11749135, EBI-10210351;
CC Q8IUG1; P48146: NPBWR2; NbExp=3; IntAct=EBI-11749135, EBI-10210114;
CC Q8IUG1; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-11749135, EBI-748927;
CC Q8IUG1; Q6NSM0: NR1D2; NbExp=3; IntAct=EBI-11749135, EBI-10250949;
CC Q8IUG1; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-11749135, EBI-1210753;
CC Q8IUG1; O95897: OLFM2; NbExp=3; IntAct=EBI-11749135, EBI-721741;
CC Q8IUG1; P32242: OTX1; NbExp=7; IntAct=EBI-11749135, EBI-740446;
CC Q8IUG1; Q8IVL6-2: P3H3; NbExp=3; IntAct=EBI-11749135, EBI-12149899;
CC Q8IUG1; O76083-2: PDE9A; NbExp=3; IntAct=EBI-11749135, EBI-11524542;
CC Q8IUG1; Q14554-2: PDIA5; NbExp=3; IntAct=EBI-11749135, EBI-12094562;
CC Q8IUG1; Q8N4B1-4: PHETA1; NbExp=3; IntAct=EBI-11749135, EBI-14131832;
CC Q8IUG1; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-11749135, EBI-14084211;
CC Q8IUG1; Q96S52: PIGS; NbExp=3; IntAct=EBI-11749135, EBI-2908273;
CC Q8IUG1; Q494U1-3: PLEKHN1; NbExp=3; IntAct=EBI-11749135, EBI-12014286;
CC Q8IUG1; P54646: PRKAA2; NbExp=3; IntAct=EBI-11749135, EBI-1383852;
CC Q8IUG1; O43741: PRKAB2; NbExp=5; IntAct=EBI-11749135, EBI-1053424;
CC Q8IUG1; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-11749135, EBI-1567797;
CC Q8IUG1; P25786: PSMA1; NbExp=3; IntAct=EBI-11749135, EBI-359352;
CC Q8IUG1; Q13308: PTK7; NbExp=3; IntAct=EBI-11749135, EBI-2803245;
CC Q8IUG1; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-11749135, EBI-7199479;
CC Q8IUG1; P15151: PVR; NbExp=3; IntAct=EBI-11749135, EBI-3919694;
CC Q8IUG1; Q9Y2K5: R3HDM2; NbExp=3; IntAct=EBI-11749135, EBI-948428;
CC Q8IUG1; Q9BTL3: RAMAC; NbExp=3; IntAct=EBI-11749135, EBI-744023;
CC Q8IUG1; Q9Y272: RASD1; NbExp=3; IntAct=EBI-11749135, EBI-740818;
CC Q8IUG1; P04843: RPN1; NbExp=3; IntAct=EBI-11749135, EBI-355963;
CC Q8IUG1; Q86WX3: RPS19BP1; NbExp=3; IntAct=EBI-11749135, EBI-4479407;
CC Q8IUG1; Q86UD0: SAPCD2; NbExp=3; IntAct=EBI-11749135, EBI-2561646;
CC Q8IUG1; A0A0S2Z4U3: SDC3; NbExp=3; IntAct=EBI-11749135, EBI-10204280;
CC Q8IUG1; O00560: SDCBP; NbExp=3; IntAct=EBI-11749135, EBI-727004;
CC Q8IUG1; Q8WWX9: SELENOM; NbExp=3; IntAct=EBI-11749135, EBI-10277687;
CC Q8IUG1; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-11749135, EBI-11955083;
CC Q8IUG1; Q86YT5: SLC13A5; NbExp=3; IntAct=EBI-11749135, EBI-12002412;
CC Q8IUG1; A1A5C7-2: SLC22A23; NbExp=3; IntAct=EBI-11749135, EBI-12081840;
CC Q8IUG1; Q9UHI7-3: SLC23A1; NbExp=3; IntAct=EBI-11749135, EBI-11998660;
CC Q8IUG1; Q92504: SLC39A7; NbExp=3; IntAct=EBI-11749135, EBI-1051105;
CC Q8IUG1; Q8N370: SLC43A2; NbExp=3; IntAct=EBI-11749135, EBI-10265149;
CC Q8IUG1; Q9UPY5: SLC7A11; NbExp=3; IntAct=EBI-11749135, EBI-3843348;
CC Q8IUG1; P49901: SMCP; NbExp=3; IntAct=EBI-11749135, EBI-750494;
CC Q8IUG1; O43278-2: SPINT1; NbExp=3; IntAct=EBI-11749135, EBI-12078338;
CC Q8IUG1; O43609: SPRY1; NbExp=3; IntAct=EBI-11749135, EBI-3866665;
CC Q8IUG1; O75716: STK16; NbExp=3; IntAct=EBI-11749135, EBI-749295;
CC Q8IUG1; Q92537: SUSD6; NbExp=3; IntAct=EBI-11749135, EBI-2866213;
CC Q8IUG1; P09758: TACSTD2; NbExp=3; IntAct=EBI-11749135, EBI-4324738;
CC Q8IUG1; Q9Y4C2-2: TCAF1; NbExp=3; IntAct=EBI-11749135, EBI-11974855;
CC Q8IUG1; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-11749135, EBI-11952651;
CC Q8IUG1; P01137: TGFB1; NbExp=3; IntAct=EBI-11749135, EBI-779636;
CC Q8IUG1; Q9BT49: THAP7; NbExp=3; IntAct=EBI-11749135, EBI-741350;
CC Q8IUG1; Q63HR2: TNS2; NbExp=5; IntAct=EBI-11749135, EBI-949753;
CC Q8IUG1; Q13432: UNC119; NbExp=3; IntAct=EBI-11749135, EBI-711260;
CC Q8IUG1; Q9BRU9: UTP23; NbExp=3; IntAct=EBI-11749135, EBI-5457544;
CC Q8IUG1; Q9UBK9: UXT; NbExp=3; IntAct=EBI-11749135, EBI-357355;
CC Q8IUG1; Q6EMK4: VASN; NbExp=3; IntAct=EBI-11749135, EBI-10249550;
CC Q8IUG1; Q8IW00: VSTM4; NbExp=3; IntAct=EBI-11749135, EBI-4311759;
CC Q8IUG1; O96014: WNT11; NbExp=3; IntAct=EBI-11749135, EBI-8058160;
CC Q8IUG1; Q9UBD3: XCL2; NbExp=3; IntAct=EBI-11749135, EBI-10319095;
CC Q8IUG1; Q9GZM5: YIPF3; NbExp=3; IntAct=EBI-11749135, EBI-743787;
CC Q8IUG1; P25490: YY1; NbExp=3; IntAct=EBI-11749135, EBI-765538;
CC Q8IUG1; Q8WTX9: ZDHHC1; NbExp=3; IntAct=EBI-11749135, EBI-2818796;
CC Q8IUG1; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-11749135, EBI-373456;
CC Q8IUG1; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-11749135, EBI-744257;
CC Q8IUG1; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-11749135, EBI-740727;
CC Q8IUG1; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-11749135, EBI-726439;
CC Q8IUG1; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-11749135, EBI-740232;
CC Q8IUG1; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-11749135, EBI-10486136;
CC Q8IUG1; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-11749135, EBI-6427977;
CC Q8IUG1; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-11749135, EBI-11090299;
CC Q8IUG1; Q96H86: ZNF764; NbExp=3; IntAct=EBI-11749135, EBI-745775;
CC Q8IUG1; Q8N393: ZNF786; NbExp=3; IntAct=EBI-11749135, EBI-10265203;
CC Q8IUG1; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11749135, EBI-11962574;
CC Q8IUG1; A0A384ME25; NbExp=3; IntAct=EBI-11749135, EBI-10211777;
CC -!- TISSUE SPECIFICITY: Expressed in the middle/upper portions of the hair
CC cortex, in the region termed the keratogenous zone.
CC {ECO:0000269|PubMed:11279113}.
CC -!- POLYMORPHISM: The sequence shown is that of allele KAP1.3.
CC {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the KRTAP type 1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA44938.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X63338; CAA44938.1; ALT_FRAME; Genomic_DNA.
DR EMBL; AJ406927; CAC27566.1; -; mRNA.
DR EMBL; AB081338; BAC15619.1; -; mRNA.
DR EMBL; AB081339; BAC15620.1; -; Genomic_DNA.
DR EMBL; BC069161; AAH69161.1; -; mRNA.
DR EMBL; BC101150; AAI01151.1; -; mRNA.
DR EMBL; BC101151; AAI01152.1; -; mRNA.
DR EMBL; BC101152; AAI01153.1; -; mRNA.
DR EMBL; BC101153; AAI01154.1; -; mRNA.
DR CCDS; CCDS42323.1; -.
DR PIR; S37649; S37649.
DR RefSeq; NP_112228.1; NM_030966.1.
DR AlphaFoldDB; Q8IUG1; -.
DR BioGRID; 123601; 176.
DR IntAct; Q8IUG1; 175.
DR BioMuta; KRTAP1-3; -.
DR DMDM; 74723628; -.
DR MassIVE; Q8IUG1; -.
DR PeptideAtlas; Q8IUG1; -.
DR PRIDE; Q8IUG1; -.
DR ProteomicsDB; 70562; -.
DR Antibodypedia; 68306; 55 antibodies from 11 providers.
DR DNASU; 81850; -.
DR Ensembl; ENST00000344363.7; ENSP00000344420.5; ENSG00000221880.4.
DR Ensembl; ENST00000575715.2; ENSP00000461303.1; ENSG00000262347.2.
DR GeneID; 81850; -.
DR KEGG; hsa:81850; -.
DR MANE-Select; ENST00000344363.7; ENSP00000344420.5; NM_030966.2; NP_112228.1.
DR UCSC; uc002hvv.4; human.
DR CTD; 81850; -.
DR GeneCards; KRTAP1-3; -.
DR HGNC; HGNC:16771; KRTAP1-3.
DR HPA; ENSG00000221880; Tissue enriched (skin).
DR MIM; 608820; gene.
DR neXtProt; NX_Q8IUG1; -.
DR OpenTargets; ENSG00000221880; -.
DR PharmGKB; PA38411; -.
DR VEuPathDB; HostDB:ENSG00000221880; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000160443; -.
DR HOGENOM; CLU_109417_0_0_1; -.
DR InParanoid; Q8IUG1; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; Q8IUG1; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR BioGRID-ORCS; 81850; 10 hits in 983 CRISPR screens.
DR GenomeRNAi; 81850; -.
DR Pharos; Q8IUG1; Tbio.
DR PRO; PR:Q8IUG1; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q8IUG1; protein.
DR Bgee; ENSG00000221880; Expressed in skin of abdomen and 36 other tissues.
DR Genevisible; Q8IUG1; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0030280; F:structural constituent of skin epidermis; NAS:UniProtKB.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 3.
DR Pfam; PF01500; Keratin_B2; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..167
FT /note="Keratin-associated protein 1-3"
FT /id="PRO_0000223902"
FT VARIANT 34
FT /note="C -> S (in allele KAP1.8B; dbSNP:rs62624960)"
FT /evidence="ECO:0000269|PubMed:12228244"
FT /id="VAR_025349"
FT VARIANT 40
FT /note="C -> CETSCCQPSCC (in allele KAP1.8A)"
FT /evidence="ECO:0000269|PubMed:12228244,
FT ECO:0000269|PubMed:1279380, ECO:0000269|PubMed:15489334"
FT /id="VAR_085002"
FT VARIANT 41..66
FT /note="Missing (in allele KAP1.9)"
FT /evidence="ECO:0000269|PubMed:12228244"
FT /id="VAR_025351"
FT VARIANT 82
FT /note="G -> R (in allele KAP1.8B)"
FT /evidence="ECO:0000269|PubMed:12228244"
FT /id="VAR_025352"
SQ SEQUENCE 167 AA; 17141 MW; 66AE68A8BDAB68BF CRC64;
MTCCQTSFCG YPSCSTSGTC GSSCCQPSCC ETSCCQPSCC QTSFCGFPSF STSGTCSSSC
CQPSCCETSC CQPSCCQTSS CGTGCGIGGG IGYGQEGSSG AVSTRIRWCR PDCRVEGTCL
PPCCVVSCTP PTCCQLHHAE ASCCRPSYCG QSCCRPVCCC YSCEPTC
