ID   KRA14_HUMAN             Reviewed;         121 AA.
AC   P0C5Y4; A6NJ92;
DT   04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 90.
DE   RecName: Full=Keratin-associated protein 1-4;
DE   AltName: Full=High sulfur keratin-associated protein 1.4;
DE   AltName: Full=Keratin-associated protein 1.4;
GN   Name=KRTAP1-4; Synonyms=KAP1.4, KRTAP1.4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [2]
RP   IDENTIFICATION, AND TISSUE SPECIFICITY.
RX   PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA   Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA   Schweizer J.;
RT   "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT   associated protein genes embedded in the type I keratin gene domain on
RT   chromosome 17q12-21.";
RL   J. Biol. Chem. 276:19440-19451(2001).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins.
CC   -!- TISSUE SPECIFICITY: Expressed in the middle/upper portions of the hair
CC       cortex, in the region termed the keratogenous zone.
CC       {ECO:0000269|PubMed:11279113}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 1 family. {ECO:0000305}.
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DR   EMBL; AC007455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS58548.1; -.
DR   RefSeq; NP_001244234.1; NM_001257305.1.
DR   AlphaFoldDB; P0C5Y4; -.
DR   STRING; 9606.ENSP00000366976; -.
DR   BioMuta; KRTAP1-4; -.
DR   DMDM; 162416160; -.
DR   MassIVE; P0C5Y4; -.
DR   PaxDb; P0C5Y4; -.
DR   PeptideAtlas; P0C5Y4; -.
DR   PRIDE; P0C5Y4; -.
DR   DNASU; 728255; -.
DR   Ensembl; ENST00000377747.5; ENSP00000366976.4; ENSG00000204887.5.
DR   Ensembl; ENST00000576814.2; ENSP00000458243.2; ENSG00000263242.2.
DR   GeneID; 728255; -.
DR   KEGG; hsa:728255; -.
DR   MANE-Select; ENST00000377747.5; ENSP00000366976.4; NM_001257305.2; NP_001244234.1.
DR   UCSC; uc031raf.2; human.
DR   CTD; 728255; -.
DR   GeneCards; KRTAP1-4; -.
DR   HGNC; HGNC:18904; KRTAP1-4.
DR   HPA; ENSG00000204887; Not detected.
DR   MIM; 608821; gene.
DR   neXtProt; NX_P0C5Y4; -.
DR   VEuPathDB; HostDB:ENSG00000204887; -.
DR   eggNOG; KOG4726; Eukaryota.
DR   GeneTree; ENSGT00940000160443; -.
DR   HOGENOM; CLU_109417_0_0_1; -.
DR   InParanoid; P0C5Y4; -.
DR   OMA; GSSCCES; -.
DR   OrthoDB; 1581613at2759; -.
DR   PhylomeDB; P0C5Y4; -.
DR   PathwayCommons; P0C5Y4; -.
DR   Reactome; R-HSA-6805567; Keratinization.
DR   BioGRID-ORCS; 728255; 13 hits in 1059 CRISPR screens.
DR   GenomeRNAi; 728255; -.
DR   Pharos; P0C5Y4; Tdark.
DR   PRO; PR:P0C5Y4; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P0C5Y4; protein.
DR   Bgee; ENSG00000204887; Expressed in skin of abdomen and 17 other tissues.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 1.
DR   Pfam; PF01500; Keratin_B2; 1.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..121
FT                   /note="Keratin-associated protein 1-4"
FT                   /id="PRO_0000312505"
SQ   SEQUENCE   121 AA;  12324 MW;  55FDE67F43900398 CRC64;
     MASCSTSGTC GSSCCQPSCC ETSCCQPSCC QTSSCGTGCG IGGGIGYGQE GSGGSVSTRI
     RWCHPDCHVE GTCLPPCYLV SCTPPSCCQL HHAEASCCRP SYCGQSCCRP ACCCHCCEPT
     C