KRA14_MOUSE
ID KRA14_MOUSE Reviewed; 167 AA.
AC O08640; O35148;
DT 09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-1997, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Keratin-associated protein 14;
DE AltName: Full=Anagen-specific protein KAP13;
DE Short=mKAP13;
DE AltName: Full=Pubertal mammary gland-specific protein 1;
GN Name=Krtap14 {ECO:0000312|MGI:MGI:1346079};
GN Synonyms=Pmg1 {ECO:0000312|EMBL:AAD47278.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAB72042.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=SWR/J {ECO:0000312|EMBL:AAB72042.1};
RC TISSUE=Mammary gland {ECO:0000312|EMBL:AAB72042.1};
RX PubMed=9287118; DOI=10.1016/s0014-5793(97)00836-3;
RA Kuhn F., Andres A.-C.;
RT "pmg-1, a novel gene specifically expressed during the invasive growth
RT phase of the mammary gland at puberty.";
RL FEBS Lett. 413:65-69(1997).
RN [2] {ECO:0000305, ECO:0000312|EMBL:BAA19678.1}
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC STRAIN=C57BL/6N {ECO:0000312|EMBL:BAA19678.1};
RC TISSUE=Skin {ECO:0000312|EMBL:BAA19678.1};
RX PubMed=9804342; DOI=10.1046/j.1523-1747.1998.00387.x;
RA Aoki N., Ito K., Ito M.;
RT "Hair follicle has a novel anagen-specific protein, mKAP13.";
RL J. Invest. Dermatol. 111:804-809(1998).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAD47278.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=10446281; DOI=10.1016/s0925-4773(99)00115-x;
RA Kuhn F., Lassing C., Range A., Mueller M., Hunziker T., Ziemiecki A.,
RA Andres A.-C.;
RT "Pmg-1 and pmg-2 constitute a novel family of KAP genes differentially
RT expressed during skin and mammary gland development.";
RL Mech. Dev. 86:193-196(1999).
RN [4] {ECO:0000312|EMBL:AAI04263.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at high levels in skin where it is found
CC predominantly in the keratogenous zone of hair follicle cortical cells
CC and at lower levels in the epithelium of the developing mammary gland.
CC {ECO:0000269|PubMed:10446281, ECO:0000269|PubMed:9287118,
CC ECO:0000269|PubMed:9804342}.
CC -!- DEVELOPMENTAL STAGE: In the developing mammary gland, expression is
CC barely detected in the immature gland at 3 weeks after birth but is
CC evident at the onset of puberty at 3.5 weeks. Expression is high at 4
CC weeks, declines at 4.5 weeks and is undetectable at 5 weeks. No
CC expression is detected in the mature mammary gland during estrus,
CC pregnancy, lactation or involution. In skin, expression starts shortly
CC after birth and reaches a first maximum at 9 days. A second peak of
CC expression is observed at 3.5 weeks, then levels decline and remain low
CC in the adult. During the hair growth cycle, detected in mid- and late-
CC anagen stages but not in catagen, telogen or early anagen phases.
CC {ECO:0000269|PubMed:10446281, ECO:0000269|PubMed:9287118,
CC ECO:0000269|PubMed:9804342}.
CC -!- SIMILARITY: Belongs to the PMG family. {ECO:0000255}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB72042.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=AAD47278.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AF003691; AAB72042.1; ALT_FRAME; mRNA.
DR EMBL; D85925; BAA19678.1; -; mRNA.
DR EMBL; AF162800; AAD47278.1; ALT_FRAME; Genomic_DNA.
DR EMBL; BC104262; AAI04263.1; -; mRNA.
DR EMBL; BC104263; AAI04264.1; -; mRNA.
DR CCDS; CCDS79476.1; -.
DR RefSeq; NP_038735.2; NM_013707.2.
DR AlphaFoldDB; O08640; -.
DR STRING; 10090.ENSMUSP00000139983; -.
DR iPTMnet; O08640; -.
DR PhosphoSitePlus; O08640; -.
DR PRIDE; O08640; -.
DR ProteomicsDB; 264799; -.
DR DNASU; 23927; -.
DR Ensembl; ENSMUST00000189774; ENSMUSP00000139983; ENSMUSG00000074928.
DR GeneID; 23927; -.
DR KEGG; mmu:23927; -.
DR UCSC; uc007zvf.1; mouse.
DR CTD; 23927; -.
DR MGI; MGI:1346079; Krtap14.
DR VEuPathDB; HostDB:ENSMUSG00000074928; -.
DR eggNOG; ENOG502TD2X; Eukaryota.
DR GeneTree; ENSGT00940000161951; -.
DR HOGENOM; CLU_111618_0_0_1; -.
DR InParanoid; O08640; -.
DR OrthoDB; 1292816at2759; -.
DR PhylomeDB; O08640; -.
DR BioGRID-ORCS; 23927; 1 hit in 65 CRISPR screens.
DR PRO; PR:O08640; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; O08640; protein.
DR Bgee; ENSMUSG00000074928; Expressed in lip and 11 other tissues.
DR ExpressionAtlas; O08640; baseline and differential.
DR Genevisible; O08640; MM.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR InterPro; IPR007951; KRTAP_PMG.
DR PANTHER; PTHR19051; PTHR19051; 1.
DR Pfam; PF05287; PMG; 1.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..167
FT /note="Keratin-associated protein 14"
FT /id="PRO_0000271176"
FT REPEAT 98..114
FT /note="1"
FT /evidence="ECO:0000255"
FT REPEAT 115..131
FT /note="2"
FT /evidence="ECO:0000255"
FT REGION 98..131
FT /note="2 X 17 AA approximate tandem repeats"
SQ SEQUENCE 167 AA; 17919 MW; E69A95C16B9B22C0 CRC64;
MSCNSCSGTF SQSFGGQLQY PISSCGSSYP NNVFYSTDLQ TPITHQLGSS LHSGCQETFC
EPTNCQTAYV VSRPCQRPFY SQRIRGPCRP CQSTFSGSLG FGSRGFQSFG CGYPSQGFGS
HGFQSVGCGT PTFSSLNCGS SFYRPTCFST KSCQSVSYQP TCGTGFF
