KRA15_HUMAN
ID KRA15_HUMAN Reviewed; 174 AA.
AC Q9BYS1; A6NJW6; A6NLZ6; B6ZDR1; Q52LP6;
DT 25-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 137.
DE RecName: Full=Keratin-associated protein 1-5;
DE AltName: Full=High sulfur keratin-associated protein 1.5;
DE AltName: Full=Keratin-associated protein 1.5;
GN Name=KRTAP1-5; Synonyms=KAP1.5, KRTAP1.5;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q9BYS1; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11741292, EBI-10173507;
CC Q9BYS1; P29972: AQP1; NbExp=3; IntAct=EBI-11741292, EBI-745213;
CC Q9BYS1; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11741292, EBI-744545;
CC Q9BYS1; Q02930-3: CREB5; NbExp=5; IntAct=EBI-11741292, EBI-10192698;
CC Q9BYS1; P06850: CRH; NbExp=3; IntAct=EBI-11741292, EBI-3870390;
CC Q9BYS1; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11741292, EBI-3867333;
CC Q9BYS1; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11741292, EBI-9679045;
CC Q9BYS1; Q8N9I5: FADS6; NbExp=3; IntAct=EBI-11741292, EBI-3943864;
CC Q9BYS1; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-11741292, EBI-11986315;
CC Q9BYS1; P28799: GRN; NbExp=3; IntAct=EBI-11741292, EBI-747754;
CC Q9BYS1; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-11741292, EBI-11978177;
CC Q9BYS1; P49639: HOXA1; NbExp=5; IntAct=EBI-11741292, EBI-740785;
CC Q9BYS1; P17482: HOXB9; NbExp=3; IntAct=EBI-11741292, EBI-745290;
CC Q9BYS1; Q5T749: KPRP; NbExp=3; IntAct=EBI-11741292, EBI-10981970;
CC Q9BYS1; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-11741292, EBI-10302392;
CC Q9BYS1; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-11741292, EBI-10172511;
CC Q9BYS1; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11741292, EBI-11958132;
CC Q9BYS1; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-11741292, EBI-11993296;
CC Q9BYS1; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-11741292, EBI-11974251;
CC Q9BYS1; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-11741292, EBI-10250562;
CC Q9BYS1; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11741292, EBI-1044640;
CC Q9BYS1; Q5T7P3: LCE1B; NbExp=4; IntAct=EBI-11741292, EBI-10245913;
CC Q9BYS1; Q5T752: LCE1D; NbExp=5; IntAct=EBI-11741292, EBI-11741311;
CC Q9BYS1; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11741292, EBI-11955335;
CC Q9BYS1; O14633: LCE2B; NbExp=3; IntAct=EBI-11741292, EBI-11478468;
CC Q9BYS1; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11741292, EBI-10246750;
CC Q9BYS1; Q5TA76: LCE3A; NbExp=4; IntAct=EBI-11741292, EBI-9394625;
CC Q9BYS1; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-11741292, EBI-6658837;
CC Q9BYS1; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-11741292, EBI-10246358;
CC Q9BYS1; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-11741292, EBI-11955689;
CC Q9BYS1; P48645: NMU; NbExp=3; IntAct=EBI-11741292, EBI-10210351;
CC Q9BYS1; Q7Z417: NUFIP2; NbExp=5; IntAct=EBI-11741292, EBI-1210753;
CC Q9BYS1; P32242: OTX1; NbExp=5; IntAct=EBI-11741292, EBI-740446;
CC Q9BYS1; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-11741292, EBI-769257;
CC Q9BYS1; O00560: SDCBP; NbExp=3; IntAct=EBI-11741292, EBI-727004;
CC Q9BYS1; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-11741292, EBI-11955083;
CC Q9BYS1; P49901: SMCP; NbExp=3; IntAct=EBI-11741292, EBI-750494;
CC Q9BYS1; O96014: WNT11; NbExp=3; IntAct=EBI-11741292, EBI-8058160;
CC Q9BYS1; P25490: YY1; NbExp=3; IntAct=EBI-11741292, EBI-765538;
CC -!- TISSUE SPECIFICITY: Expressed in the middle/upper portions of the hair
CC cortex, in the region termed the keratogenous zone.
CC {ECO:0000269|PubMed:11279113}.
CC -!- SIMILARITY: Belongs to the KRTAP type 1 family. {ECO:0000305}.
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DR EMBL; AJ406928; CAC27567.1; -; mRNA.
DR EMBL; AC007455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471152; EAW60697.1; -; Genomic_DNA.
DR EMBL; BC069533; AAH69533.1; -; mRNA.
DR EMBL; BC093841; AAH93841.1; -; mRNA.
DR EMBL; BC101555; AAI01556.1; -; mRNA.
DR CCDS; CCDS42321.1; -.
DR RefSeq; NP_114163.1; NM_031957.1.
DR AlphaFoldDB; Q9BYS1; -.
DR BioGRID; 123806; 37.
DR IntAct; Q9BYS1; 39.
DR STRING; 9606.ENSP00000355302; -.
DR BioMuta; KRTAP1-5; -.
DR DMDM; 56749988; -.
DR MassIVE; Q9BYS1; -.
DR PaxDb; Q9BYS1; -.
DR PeptideAtlas; Q9BYS1; -.
DR PRIDE; Q9BYS1; -.
DR ProteomicsDB; 79699; -.
DR Antibodypedia; 57659; 26 antibodies from 13 providers.
DR Ensembl; ENST00000361883.6; ENSP00000355302.5; ENSG00000221852.5.
DR Ensembl; ENST00000572212.1; ENSP00000461651.1; ENSG00000261862.2.
DR GeneID; 83895; -.
DR KEGG; hsa:83895; -.
DR MANE-Select; ENST00000361883.6; ENSP00000355302.5; NM_031957.2; NP_114163.1.
DR UCSC; uc002hvu.4; human.
DR CTD; 83895; -.
DR GeneCards; KRTAP1-5; -.
DR HGNC; HGNC:16777; KRTAP1-5.
DR HPA; ENSG00000221852; Tissue enriched (skin).
DR MIM; 608822; gene.
DR neXtProt; NX_Q9BYS1; -.
DR OpenTargets; ENSG00000221852; -.
DR PharmGKB; PA38417; -.
DR VEuPathDB; HostDB:ENSG00000221852; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000160443; -.
DR HOGENOM; CLU_109417_0_0_1; -.
DR InParanoid; Q9BYS1; -.
DR OMA; CGGESCR; -.
DR PhylomeDB; Q9BYS1; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; Q9BYS1; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q9BYS1; -.
DR BioGRID-ORCS; 83895; 8 hits in 1020 CRISPR screens.
DR GenomeRNAi; 83895; -.
DR Pharos; Q9BYS1; Tdark.
DR PRO; PR:Q9BYS1; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9BYS1; protein.
DR Bgee; ENSG00000221852; Expressed in stromal cell of endometrium and 45 other tissues.
DR Genevisible; Q9BYS1; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 3.
DR Pfam; PF01500; Keratin_B2; 2.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..174
FT /note="Keratin-associated protein 1-5"
FT /id="PRO_0000185161"
FT REGION 3..172
FT /note="15 X 5 AA repeats of C-C-[QEPVRC]-[TPIVLE]-[SRHVP]"
SQ SEQUENCE 174 AA; 18010 MW; FD8F32C958A9B291 CRC64;
MTCCQTSFCG YPSFSISGTC GSSCCQPSCC ETSCCQPRSC QTSFCGFPSF STSGTCSSSC
CQPSCCETSC CQPSCCETSC CQPSCCQISS CGTGCGIGGG ISYGQEGSSG AVSTRIRWCR
PDSRVEGTYL PPCCVVSCTP PSCCQLHHAQ ASCCRPSYCG QSCCRPVCCC EPTC
