KRA23_HUMAN
ID KRA23_HUMAN Reviewed; 128 AA.
AC P0C7H8;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 28-NOV-2012, sequence version 2.
DT 03-AUG-2022, entry version 89.
DE RecName: Full=Keratin-associated protein 2-3;
DE AltName: Full=High sulfur keratin-associated protein 2.4;
DE AltName: Full=Keratin-associated protein 2.3;
GN Name=KRTAP2-3; Synonyms=KAP2.3, KRTAP2.3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC P0C7H8; P82987: ADAMTSL3; NbExp=3; IntAct=EBI-10196781, EBI-10221726;
CC P0C7H8; Q14781: CBX2; NbExp=3; IntAct=EBI-10196781, EBI-745934;
CC P0C7H8; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-10196781, EBI-741032;
CC P0C7H8; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10196781, EBI-10172150;
CC P0C7H8; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-10196781, EBI-7199479;
CC P0C7H8; P62857: RPS28; NbExp=3; IntAct=EBI-10196781, EBI-353027;
CC P0C7H8; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10196781, EBI-10313866;
CC P0C7H8; Q8WZ59: TMEM190; NbExp=3; IntAct=EBI-10196781, EBI-10278423;
CC P0C7H8; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-10196781, EBI-6427977;
CC -!- SIMILARITY: Belongs to the KRTAP type 2 family. {ECO:0000305}.
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DR EMBL; AC100808; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS54123.1; -.
DR RefSeq; NP_001158724.1; NM_001165252.1.
DR RefSeq; NP_149440.1; NM_033184.3.
DR AlphaFoldDB; P0C7H8; -.
DR BioGRID; 124458; 95.
DR BioGRID; 611123; 89.
DR IntAct; P0C7H8; 9.
DR STRING; 9606.ENSP00000375237; -.
DR BioMuta; KRTAP2-3; -.
DR DMDM; 425906047; -.
DR jPOST; P0C7H8; -.
DR MassIVE; P0C7H8; -.
DR PaxDb; P0C7H8; -.
DR PeptideAtlas; P0C7H8; -.
DR PRIDE; P0C7H8; -.
DR ProteomicsDB; 52334; -.
DR Antibodypedia; 68313; 1 antibodies from 1 providers.
DR DNASU; 85294; -.
DR Ensembl; ENST00000391418.3; ENSP00000375237.2; ENSG00000212724.3.
DR Ensembl; ENST00000570303.2; ENSP00000459261.1; ENSG00000262862.2.
DR GeneID; 730755; -.
DR GeneID; 85294; -.
DR KEGG; hsa:730755; -.
DR KEGG; hsa:85294; -.
DR MANE-Select; ENST00000391418.3; ENSP00000375237.2; NM_001165252.2; NP_001158724.1.
DR MANE-Select; ENST00000394015.3; ENSP00000377583.2; NM_033184.4; NP_149440.1.
DR CTD; 730755; -.
DR CTD; 85294; -.
DR GeneCards; KRTAP2-3; -.
DR HGNC; HGNC:18906; KRTAP2-3.
DR HPA; ENSG00000212724; Tissue enriched (skin).
DR neXtProt; NX_P0C7H8; -.
DR OpenTargets; ENSG00000212724; -.
DR OpenTargets; ENSG00000213417; -.
DR VEuPathDB; HostDB:ENSG00000212724; -.
DR eggNOG; KOG4726; Eukaryota.
DR HOGENOM; CLU_113141_3_0_1; -.
DR InParanoid; P0C7H8; -.
DR OMA; KNTVCRK; -.
DR OrthoDB; 1609178at2759; -.
DR PhylomeDB; P0C7H8; -.
DR PathwayCommons; P0C7H8; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; P0C7H8; -.
DR BioGRID-ORCS; 730755; 17 hits in 262 CRISPR screens.
DR BioGRID-ORCS; 85294; 15 hits in 615 CRISPR screens.
DR Pharos; P0C7H8; Tdark.
DR PRO; PR:P0C7H8; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; P0C7H8; protein.
DR Bgee; ENSG00000212724; Expressed in islet of Langerhans and 20 other tissues.
DR Genevisible; P0C7H8; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
DR Pfam; PF01500; Keratin_B2; 1.
DR Pfam; PF13885; Keratin_B2_2; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..128
FT /note="Keratin-associated protein 2-3"
FT /id="PRO_0000331452"
FT REGION 5..112
FT /note="10 X 5 AA repeats of C-C-[CDPQRWG]-[APRS]-[CIPSTVD]"
SQ SEQUENCE 128 AA; 13480 MW; 1617AA40943D90F8 CRC64;
MTGSCCGSTL SSLSYGGGCC QPCCCRDPCC CRPVTCQTTV CRPVTCVPRC TRPICEPCRR
PVCCDPCSLQ EGCCRPITCC PSSCTAVVCR PCCWATTCCQ PVSVQSPCCR PPCGQPTPCS
TTCRTSSC
