KRA24_HUMAN
ID KRA24_HUMAN Reviewed; 128 AA.
AC Q9BYR9; Q495J2;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Keratin-associated protein 2-4;
DE AltName: Full=High sulfur keratin-associated protein 2.4;
DE AltName: Full=Keratin-associated protein 2.4;
GN Name=KRTAP2-4; Synonyms=KAP2.4, KRTAP2.4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q9BYR9; P82987: ADAMTSL3; NbExp=3; IntAct=EBI-14065470, EBI-10221726;
CC Q9BYR9; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-14065470, EBI-742750;
CC Q9BYR9; A8KA13: BCL6B; NbExp=3; IntAct=EBI-14065470, EBI-10174813;
CC Q9BYR9; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-14065470, EBI-745073;
CC Q9BYR9; Q6NUJ2: C11orf87; NbExp=3; IntAct=EBI-14065470, EBI-6660291;
CC Q9BYR9; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-14065470, EBI-744545;
CC Q9BYR9; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-14065470, EBI-741528;
CC Q9BYR9; Q02930-3: CREB5; NbExp=3; IntAct=EBI-14065470, EBI-10192698;
CC Q9BYR9; Q9UBR2: CTSZ; NbExp=3; IntAct=EBI-14065470, EBI-8636823;
CC Q9BYR9; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-14065470, EBI-3867333;
CC Q9BYR9; Q6P158: DHX57; NbExp=3; IntAct=EBI-14065470, EBI-1051531;
CC Q9BYR9; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-14065470, EBI-9679045;
CC Q9BYR9; Q3B820: FAM161A; NbExp=3; IntAct=EBI-14065470, EBI-719941;
CC Q9BYR9; P57678: GEMIN4; NbExp=3; IntAct=EBI-14065470, EBI-356700;
CC Q9BYR9; Q86UU5: GGN; NbExp=3; IntAct=EBI-14065470, EBI-10259069;
CC Q9BYR9; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-14065470, EBI-11956675;
CC Q9BYR9; Q03014: HHEX; NbExp=3; IntAct=EBI-14065470, EBI-747421;
CC Q9BYR9; P49639: HOXA1; NbExp=3; IntAct=EBI-14065470, EBI-740785;
CC Q9BYR9; P17482: HOXB9; NbExp=3; IntAct=EBI-14065470, EBI-745290;
CC Q9BYR9; Q969P0: IGSF8; NbExp=3; IntAct=EBI-14065470, EBI-8293590;
CC Q9BYR9; P16144-2: ITGB4; NbExp=3; IntAct=EBI-14065470, EBI-11051601;
CC Q9BYR9; Q15040: JOSD1; NbExp=3; IntAct=EBI-14065470, EBI-2510602;
CC Q9BYR9; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-14065470, EBI-6426443;
CC Q9BYR9; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-14065470, EBI-11959885;
CC Q9BYR9; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-14065470, EBI-10176396;
CC Q9BYR9; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-14065470, EBI-10302392;
CC Q9BYR9; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-14065470, EBI-739863;
CC Q9BYR9; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-14065470, EBI-11958132;
CC Q9BYR9; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-14065470, EBI-11993296;
CC Q9BYR9; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-14065470, EBI-11958178;
CC Q9BYR9; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-14065470, EBI-3958099;
CC Q9BYR9; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-14065470, EBI-1044640;
CC Q9BYR9; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-14065470, EBI-1043191;
CC Q9BYR9; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-14065470, EBI-11958364;
CC Q9BYR9; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-14065470, EBI-10245913;
CC Q9BYR9; Q5T752: LCE1D; NbExp=3; IntAct=EBI-14065470, EBI-11741311;
CC Q9BYR9; Q5T753: LCE1E; NbExp=3; IntAct=EBI-14065470, EBI-11955335;
CC Q9BYR9; Q5T754: LCE1F; NbExp=6; IntAct=EBI-14065470, EBI-11958008;
CC Q9BYR9; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-14065470, EBI-10246607;
CC Q9BYR9; O14633: LCE2B; NbExp=3; IntAct=EBI-14065470, EBI-11478468;
CC Q9BYR9; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-14065470, EBI-11973993;
CC Q9BYR9; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-14065470, EBI-10246750;
CC Q9BYR9; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-14065470, EBI-9394625;
CC Q9BYR9; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-14065470, EBI-10245291;
CC Q9BYR9; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-14065470, EBI-6658837;
CC Q9BYR9; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-14065470, EBI-739832;
CC Q9BYR9; Q96EZ8: MCRS1; NbExp=3; IntAct=EBI-14065470, EBI-348259;
CC Q9BYR9; Q13875-3: MOBP; NbExp=3; IntAct=EBI-14065470, EBI-12013470;
CC Q9BYR9; Q969G9: NKD1; NbExp=3; IntAct=EBI-14065470, EBI-1538217;
CC Q9BYR9; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-14065470, EBI-22310682;
CC Q9BYR9; Q9NQX5: NPDC1; NbExp=3; IntAct=EBI-14065470, EBI-748927;
CC Q9BYR9; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-14065470, EBI-1210753;
CC Q9BYR9; P32242: OTX1; NbExp=3; IntAct=EBI-14065470, EBI-740446;
CC Q9BYR9; Q15077: P2RY6; NbExp=3; IntAct=EBI-14065470, EBI-10235794;
CC Q9BYR9; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-14065470, EBI-14084211;
CC Q9BYR9; Q96S52: PIGS; NbExp=3; IntAct=EBI-14065470, EBI-2908273;
CC Q9BYR9; O43741: PRKAB2; NbExp=3; IntAct=EBI-14065470, EBI-1053424;
CC Q9BYR9; O75783: RHBDL1; NbExp=3; IntAct=EBI-14065470, EBI-12104986;
CC Q9BYR9; A0A0S2Z4U3: SDC3; NbExp=6; IntAct=EBI-14065470, EBI-10204280;
CC Q9BYR9; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-14065470, EBI-11955083;
CC Q9BYR9; A0A024R4B0: SPATA3; NbExp=3; IntAct=EBI-14065470, EBI-14123856;
CC Q9BYR9; Q7Z698: SPRED2; NbExp=3; IntAct=EBI-14065470, EBI-7082156;
CC Q9BYR9; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-14065470, EBI-11952651;
CC Q9BYR9; Q05952: TNP2; NbExp=3; IntAct=EBI-14065470, EBI-12039775;
CC Q9BYR9; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-14065470, EBI-5235829;
CC Q9BYR9; P49638: TTPA; NbExp=3; IntAct=EBI-14065470, EBI-10210710;
CC Q9BYR9; Q6EMK4: VASN; NbExp=3; IntAct=EBI-14065470, EBI-10249550;
CC Q9BYR9; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-14065470, EBI-11957238;
CC Q9BYR9; P25490: YY1; NbExp=3; IntAct=EBI-14065470, EBI-765538;
CC Q9BYR9; O43167: ZBTB24; NbExp=3; IntAct=EBI-14065470, EBI-744471;
CC Q9BYR9; Q8WTX9: ZDHHC1; NbExp=3; IntAct=EBI-14065470, EBI-2818796;
CC Q9BYR9; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-14065470, EBI-11962760;
CC Q9BYR9; P49910: ZNF165; NbExp=3; IntAct=EBI-14065470, EBI-741694;
CC Q9BYR9; O43296: ZNF264; NbExp=3; IntAct=EBI-14065470, EBI-4395808;
CC Q9BYR9; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-14065470, EBI-726439;
CC Q9BYR9; Q8N8L2: ZNF491; NbExp=3; IntAct=EBI-14065470, EBI-12019860;
CC Q9BYR9; Q96C55: ZNF524; NbExp=3; IntAct=EBI-14065470, EBI-10283126;
CC Q9BYR9; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-14065470, EBI-10273713;
CC Q9BYR9; Q86XF7: ZNF575; NbExp=3; IntAct=EBI-14065470, EBI-14069183;
CC Q9BYR9; Q96N58: ZNF578; NbExp=3; IntAct=EBI-14065470, EBI-11955189;
CC Q9BYR9; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-14065470, EBI-745520;
CC Q9BYR9; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-14065470, EBI-6427977;
CC Q9BYR9; Q499Z4: ZNF672; NbExp=3; IntAct=EBI-14065470, EBI-12146251;
CC Q9BYR9; Q96H86: ZNF764; NbExp=3; IntAct=EBI-14065470, EBI-745775;
CC Q9BYR9; Q8N393: ZNF786; NbExp=3; IntAct=EBI-14065470, EBI-10265203;
CC Q9BYR9; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-14065470, EBI-10240849;
CC -!- TISSUE SPECIFICITY: Expressed specifically in the middle/upper portions
CC of the hair cortex, in the region termed the keratogenous zone.
CC {ECO:0000269|PubMed:11279113}.
CC -!- SIMILARITY: Belongs to the KRTAP type 2 family. {ECO:0000305}.
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DR EMBL; AJ406930; CAC27569.1; -; mRNA.
DR EMBL; BC063625; AAH63625.1; -; mRNA.
DR EMBL; BC101147; AAI01148.1; -; mRNA.
DR EMBL; BC101148; AAI01149.1; -; mRNA.
DR EMBL; BC101149; AAI01150.1; -; mRNA.
DR CCDS; CCDS32648.1; -.
DR RefSeq; NP_001158724.1; NM_001165252.1.
DR RefSeq; NP_149440.1; NM_033184.3.
DR AlphaFoldDB; Q9BYR9; -.
DR BioGRID; 124458; 95.
DR BioGRID; 611123; 89.
DR IntAct; Q9BYR9; 86.
DR BioMuta; KRTAP2-4; -.
DR DMDM; 78100181; -.
DR jPOST; Q9BYR9; -.
DR MassIVE; Q9BYR9; -.
DR PRIDE; Q9BYR9; -.
DR ProteomicsDB; 79698; -.
DR Antibodypedia; 73162; 56 antibodies from 8 providers.
DR DNASU; 85294; -.
DR Ensembl; ENST00000394015.3; ENSP00000377583.2; ENSG00000213417.3.
DR Ensembl; ENST00000572903.2; ENSP00000458927.1; ENSG00000263091.2.
DR GeneID; 730755; -.
DR GeneID; 85294; -.
DR KEGG; hsa:730755; -.
DR KEGG; hsa:85294; -.
DR MANE-Select; ENST00000391418.3; ENSP00000375237.2; NM_001165252.2; NP_001158724.1.
DR MANE-Select; ENST00000394015.3; ENSP00000377583.2; NM_033184.4; NP_149440.1.
DR UCSC; uc002hvx.4; human.
DR CTD; 730755; -.
DR CTD; 85294; -.
DR GeneCards; KRTAP2-4; -.
DR HGNC; HGNC:18891; KRTAP2-4.
DR HPA; ENSG00000213417; Tissue enriched (skin).
DR neXtProt; NX_Q9BYR9; -.
DR OpenTargets; ENSG00000212724; -.
DR OpenTargets; ENSG00000213417; -.
DR PharmGKB; PA38743; -.
DR VEuPathDB; HostDB:ENSG00000213417; -.
DR GeneTree; ENSGT00940000162736; -.
DR HOGENOM; CLU_113141_3_0_1; -.
DR InParanoid; Q9BYR9; -.
DR OMA; ISCSCRP; -.
DR OrthoDB; 1609178at2759; -.
DR PhylomeDB; Q9BYR9; -.
DR PathwayCommons; Q9BYR9; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q9BYR9; -.
DR BioGRID-ORCS; 730755; 17 hits in 262 CRISPR screens.
DR BioGRID-ORCS; 85294; 15 hits in 615 CRISPR screens.
DR Pharos; Q9BYR9; Tdark.
DR PRO; PR:Q9BYR9; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9BYR9; protein.
DR Bgee; ENSG00000213417; Expressed in skin of abdomen and 33 other tissues.
DR Genevisible; Q9BYR9; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
DR Pfam; PF01500; Keratin_B2; 1.
DR Pfam; PF13885; Keratin_B2_2; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..128
FT /note="Keratin-associated protein 2-4"
FT /id="PRO_0000185162"
FT REGION 5..112
FT /note="10 X 5 AA repeats of C-C-[CDPQRW]-[ADPRS]-[CIPSTV]"
SQ SEQUENCE 128 AA; 13480 MW; 1617AA40943D90F8 CRC64;
MTGSCCGSTL SSLSYGGGCC QPCCCRDPCC CRPVTCQTTV CRPVTCVPRC TRPICEPCRR
PVCCDPCSLQ EGCCRPITCC PSSCTAVVCR PCCWATTCCQ PVSVQSPCCR PPCGQPTPCS
TTCRTSSC
