KRA31_HUMAN
ID KRA31_HUMAN Reviewed; 98 AA.
AC Q9BYR8; Q14DM4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Keratin-associated protein 3-1;
DE AltName: Full=High sulfur keratin-associated protein 3.1;
DE AltName: Full=Keratin-associated protein 3.1;
GN Name=KRTAP3-1; Synonyms=KAP3.1, KRTAP3.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q9BYR8; O43184-4: ADAM12; NbExp=5; IntAct=EBI-9996449, EBI-12006944;
CC Q9BYR8; P21549: AGXT; NbExp=3; IntAct=EBI-9996449, EBI-727098;
CC Q9BYR8; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-9996449, EBI-12224467;
CC Q9BYR8; P18075: BMP7; NbExp=3; IntAct=EBI-9996449, EBI-1035195;
CC Q9BYR8; Q9H1P6: C20orf85; NbExp=3; IntAct=EBI-9996449, EBI-12155483;
CC Q9BYR8; P38936: CDKN1A; NbExp=3; IntAct=EBI-9996449, EBI-375077;
CC Q9BYR8; P08218: CELA2B; NbExp=3; IntAct=EBI-9996449, EBI-11478642;
CC Q9BYR8; Q8TCT0: CERK; NbExp=3; IntAct=EBI-9996449, EBI-10274247;
CC Q9BYR8; P27918: CFP; NbExp=3; IntAct=EBI-9996449, EBI-9038570;
CC Q9BYR8; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-9996449, EBI-741032;
CC Q9BYR8; Q02930-3: CREB5; NbExp=3; IntAct=EBI-9996449, EBI-10192698;
CC Q9BYR8; Q99895: CTRC; NbExp=3; IntAct=EBI-9996449, EBI-10295404;
CC Q9BYR8; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-9996449, EBI-3867333;
CC Q9BYR8; Q9NQL9: DMRT3; NbExp=5; IntAct=EBI-9996449, EBI-9679045;
CC Q9BYR8; Q92608: DOCK2; NbExp=3; IntAct=EBI-9996449, EBI-448771;
CC Q9BYR8; Q92567-2: FAM168A; NbExp=3; IntAct=EBI-9996449, EBI-11978259;
CC Q9BYR8; Q8WU58: FAM222B; NbExp=3; IntAct=EBI-9996449, EBI-2807642;
CC Q9BYR8; O75593: FOXH1; NbExp=3; IntAct=EBI-9996449, EBI-1759806;
CC Q9BYR8; O43559: FRS3; NbExp=3; IntAct=EBI-9996449, EBI-725515;
CC Q9BYR8; P23769: GATA2; NbExp=3; IntAct=EBI-9996449, EBI-2806671;
CC Q9BYR8; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-9996449, EBI-11975289;
CC Q9BYR8; Q13227: GPS2; NbExp=3; IntAct=EBI-9996449, EBI-713355;
CC Q9BYR8; P09211: GSTP1; NbExp=3; IntAct=EBI-9996449, EBI-353467;
CC Q9BYR8; P08631-2: HCK; NbExp=3; IntAct=EBI-9996449, EBI-9834454;
CC Q9BYR8; Q9UBP5: HEY2; NbExp=3; IntAct=EBI-9996449, EBI-750630;
CC Q9BYR8; Q5SUL5: HLA-A; NbExp=3; IntAct=EBI-9996449, EBI-8561769;
CC Q9BYR8; P17482: HOXB9; NbExp=3; IntAct=EBI-9996449, EBI-745290;
CC Q9BYR8; O43593: HR; NbExp=3; IntAct=EBI-9996449, EBI-2880706;
CC Q9BYR8; Q9ULV5-2: HSF4; NbExp=3; IntAct=EBI-9996449, EBI-12056251;
CC Q9BYR8; Q14005-2: IL16; NbExp=3; IntAct=EBI-9996449, EBI-17178971;
CC Q9BYR8; P16144-2: ITGB4; NbExp=3; IntAct=EBI-9996449, EBI-11051601;
CC Q9BYR8; Q92993: KAT5; NbExp=3; IntAct=EBI-9996449, EBI-399080;
CC Q9BYR8; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-9996449, EBI-10171774;
CC Q9BYR8; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-9996449, EBI-11953846;
CC Q9BYR8; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-9996449, EBI-10241252;
CC Q9BYR8; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-9996449, EBI-11992140;
CC Q9BYR8; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-9996449, EBI-3957672;
CC Q9BYR8; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-9996449, EBI-10302392;
CC Q9BYR8; Q9BQ66: KRTAP4-12; NbExp=3; IntAct=EBI-9996449, EBI-739863;
CC Q9BYR8; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-9996449, EBI-12111050;
CC Q9BYR8; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-9996449, EBI-1043191;
CC Q9BYR8; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-9996449, EBI-11958364;
CC Q9BYR8; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-9996449, EBI-10245913;
CC Q9BYR8; O14633: LCE2B; NbExp=3; IntAct=EBI-9996449, EBI-11478468;
CC Q9BYR8; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-9996449, EBI-9394625;
CC Q9BYR8; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-9996449, EBI-6658837;
CC Q9BYR8; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-9996449, EBI-10246358;
CC Q9BYR8; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-9996449, EBI-11955689;
CC Q9BYR8; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-9996449, EBI-11742507;
CC Q9BYR8; P61968: LMO4; NbExp=3; IntAct=EBI-9996449, EBI-2798728;
CC Q9BYR8; Q15345: LRRC41; NbExp=3; IntAct=EBI-9996449, EBI-721408;
CC Q9BYR8; O60336: MAPKBP1; NbExp=3; IntAct=EBI-9996449, EBI-947402;
CC Q9BYR8; Q9NQ50: MRPL40; NbExp=3; IntAct=EBI-9996449, EBI-1053902;
CC Q9BYR8; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-9996449, EBI-2858213;
CC Q9BYR8; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-9996449, EBI-945833;
CC Q9BYR8; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-9996449, EBI-741158;
CC Q9BYR8; P32242: OTX1; NbExp=3; IntAct=EBI-9996449, EBI-740446;
CC Q9BYR8; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-9996449, EBI-11022007;
CC Q9BYR8; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-9996449, EBI-11956269;
CC Q9BYR8; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-9996449, EBI-14084211;
CC Q9BYR8; Q9C010-2: PKIB; NbExp=3; IntAct=EBI-9996449, EBI-12886396;
CC Q9BYR8; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-9996449, EBI-769257;
CC Q9BYR8; O15160: POLR1C; NbExp=3; IntAct=EBI-9996449, EBI-1055079;
CC Q9BYR8; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-9996449, EBI-12000762;
CC Q9BYR8; P17252: PRKCA; NbExp=3; IntAct=EBI-9996449, EBI-1383528;
CC Q9BYR8; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-9996449, EBI-7199479;
CC Q9BYR8; P15151: PVR; NbExp=3; IntAct=EBI-9996449, EBI-3919694;
CC Q9BYR8; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-9996449, EBI-740343;
CC Q9BYR8; Q6P9E2: RECK; NbExp=3; IntAct=EBI-9996449, EBI-10253121;
CC Q9BYR8; Q96HR9-2: REEP6; NbExp=3; IntAct=EBI-9996449, EBI-14065960;
CC Q9BYR8; Q7L0R7: RNF44; NbExp=3; IntAct=EBI-9996449, EBI-2845060;
CC Q9BYR8; Q7Z3H4: SAMD7; NbExp=3; IntAct=EBI-9996449, EBI-12148649;
CC Q9BYR8; Q15047-2: SETDB1; NbExp=3; IntAct=EBI-9996449, EBI-9090795;
CC Q9BYR8; Q92922: SMARCC1; NbExp=3; IntAct=EBI-9996449, EBI-355653;
CC Q9BYR8; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-9996449, EBI-11959123;
CC Q9BYR8; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-9996449, EBI-8644516;
CC Q9BYR8; Q96LM6: TEX37; NbExp=3; IntAct=EBI-9996449, EBI-743976;
CC Q9BYR8; O43711: TLX3; NbExp=3; IntAct=EBI-9996449, EBI-3939165;
CC Q9BYR8; Q6EMK4: VASN; NbExp=5; IntAct=EBI-9996449, EBI-10249550;
CC Q9BYR8; O95231: VENTX; NbExp=3; IntAct=EBI-9996449, EBI-10191303;
CC Q9BYR8; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-9996449, EBI-11957216;
CC Q9BYR8; Q64LD2-2: WDR25; NbExp=3; IntAct=EBI-9996449, EBI-12032042;
CC Q9BYR8; P61981: YWHAG; NbExp=3; IntAct=EBI-9996449, EBI-359832;
CC Q9BYR8; A2RRC6: ZFHX2; NbExp=3; IntAct=EBI-9996449, EBI-11994144;
CC Q9BYR8; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-9996449, EBI-744257;
CC Q9BYR8; Q9NWS9-2: ZNF446; NbExp=3; IntAct=EBI-9996449, EBI-740232;
CC -!- SIMILARITY: Belongs to the KRTAP type 3 family. {ECO:0000305}.
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DR EMBL; AJ406931; CAC27570.1; -; mRNA.
DR EMBL; BC113077; AAI13078.1; -; mRNA.
DR EMBL; BC113078; AAI13079.1; -; mRNA.
DR CCDS; CCDS32645.1; -.
DR RefSeq; NP_114164.1; NM_031958.1.
DR AlphaFoldDB; Q9BYR8; -.
DR BioGRID; 123807; 82.
DR IntAct; Q9BYR8; 88.
DR STRING; 9606.ENSP00000375430; -.
DR BioMuta; KRTAP3-1; -.
DR DMDM; 38372629; -.
DR MassIVE; Q9BYR8; -.
DR PaxDb; Q9BYR8; -.
DR PeptideAtlas; Q9BYR8; -.
DR PRIDE; Q9BYR8; -.
DR ProteomicsDB; 79697; -.
DR Antibodypedia; 76771; 28 antibodies from 5 providers.
DR DNASU; 83896; -.
DR Ensembl; ENST00000391588.3; ENSP00000375430.1; ENSG00000212901.4.
DR Ensembl; ENST00000571440.2; ENSP00000459883.1; ENSG00000262068.3.
DR GeneID; 83896; -.
DR KEGG; hsa:83896; -.
DR MANE-Select; ENST00000391588.3; ENSP00000375430.1; NM_031958.2; NP_114164.1.
DR UCSC; uc002hvt.2; human.
DR CTD; 83896; -.
DR GeneCards; KRTAP3-1; -.
DR HGNC; HGNC:16778; KRTAP3-1.
DR HPA; ENSG00000212901; Tissue enriched (skin).
DR neXtProt; NX_Q9BYR8; -.
DR OpenTargets; ENSG00000212901; -.
DR PharmGKB; PA38418; -.
DR VEuPathDB; HostDB:ENSG00000212901; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00390000001157; -.
DR HOGENOM; CLU_2359185_0_0_1; -.
DR InParanoid; Q9BYR8; -.
DR OMA; CCEPDTY; -.
DR OrthoDB; 1591683at2759; -.
DR PhylomeDB; Q9BYR8; -.
DR TreeFam; TF338042; -.
DR PathwayCommons; Q9BYR8; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q9BYR8; -.
DR BioGRID-ORCS; 83896; 9 hits in 1060 CRISPR screens.
DR GenomeRNAi; 83896; -.
DR Pharos; Q9BYR8; Tdark.
DR PRO; PR:Q9BYR8; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9BYR8; protein.
DR Bgee; ENSG00000212901; Expressed in skin of abdomen and 61 other tissues.
DR Genevisible; Q9BYR8; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR007659; Keratin_matx.
DR PANTHER; PTHR23260; PTHR23260; 1.
DR Pfam; PF04579; Keratin_matx; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..98
FT /note="Keratin-associated protein 3-1"
FT /id="PRO_0000185163"
FT REPEAT 3..7
FT /note="1"
FT REPEAT 8..12
FT /note="2"
FT REPEAT 47..51
FT /note="3"
FT REPEAT 55..59
FT /note="4"
FT REGION 3..59
FT /note="4 X 5 AA repeats of C-C-X(3)"
SQ SEQUENCE 98 AA; 10539 MW; 59934FD69880C797 CRC64;
MYCCALRSCS VPTGPATTFC SFDKSCRCGV CLPSTCPHEI SLLQPICCDT CPPPCCKPDT
YVPTCWLLNN CHPTPGLSGI NLTTYVQPGC ESPCEPRC
