KRA31_MOUSE
ID KRA31_MOUSE Reviewed; 98 AA.
AC A2A591; O08634;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Keratin-associated protein 3-1;
DE AltName: Full=High-sulfur keratin protein {ECO:0000312|EMBL:BAA19685.1};
GN Name=Krtap3-1 {ECO:0000312|MGI:MGI:1916723};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0000312|EMBL:CAM19191.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-98.
RC TISSUE=Skin {ECO:0000312|EMBL:BAA19685.1};
RA Aoki N.;
RT "murine cDNA for high-sulfur keratin.";
RL Submitted (JUL-1996) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KRTAP type 3 family.
CC {ECO:0000250|UniProtKB:Q9BYR8}.
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DR EMBL; AL591417; CAM19191.1; -; Genomic_DNA.
DR EMBL; D86424; BAA19685.1; -; mRNA.
DR CCDS; CCDS48907.1; -.
DR RefSeq; NP_076000.1; NM_023511.1.
DR AlphaFoldDB; A2A591; -.
DR STRING; 10090.ENSMUSP00000053940; -.
DR PaxDb; A2A591; -.
DR PeptideAtlas; A2A591; -.
DR PRIDE; A2A591; -.
DR Antibodypedia; 76771; 28 antibodies from 5 providers.
DR Ensembl; ENSMUST00000055502; ENSMUSP00000053940; ENSMUSG00000047564.
DR GeneID; 69473; -.
DR KEGG; mmu:69473; -.
DR UCSC; uc007ljb.1; mouse.
DR CTD; 83896; -.
DR MGI; MGI:1916723; Krtap3-1.
DR VEuPathDB; HostDB:ENSMUSG00000047564; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00390000001157; -.
DR HOGENOM; CLU_2359185_0_0_1; -.
DR InParanoid; A2A591; -.
DR OMA; CCEPDTY; -.
DR OrthoDB; 1591683at2759; -.
DR PhylomeDB; A2A591; -.
DR TreeFam; TF338042; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR BioGRID-ORCS; 69473; 3 hits in 70 CRISPR screens.
DR PRO; PR:A2A591; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; A2A591; protein.
DR Bgee; ENSMUSG00000047564; Expressed in lip and 19 other tissues.
DR Genevisible; A2A591; MM.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR007659; Keratin_matx.
DR PANTHER; PTHR23260; PTHR23260; 1.
DR Pfam; PF04579; Keratin_matx; 1.
PE 3: Inferred from homology;
KW Acetylation; Keratin; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P02447"
FT CHAIN 2..98
FT /note="Keratin-associated protein 3-1"
FT /id="PRO_0000358594"
FT REPEAT 3..7
FT /note="1"
FT /evidence="ECO:0000255"
FT REPEAT 8..12
FT /note="2"
FT /evidence="ECO:0000255"
FT REPEAT 47..51
FT /note="3"
FT /evidence="ECO:0000255"
FT REPEAT 55..59
FT /note="4"
FT /evidence="ECO:0000255"
FT REGION 3..59
FT /note="4 X 5 AA repeats of C-C-X(3)"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P02447"
SQ SEQUENCE 98 AA; 10271 MW; DBB00DB3EB4B57F2 CRC64;
MACCVARCCS VPTGPATTIC SSDKSCRCGV CLPSTCPHEI SLLQPTCCDP CPPPCCQPEV
YVPTCWLLNS CHPTPGLSGI NLTTYVQPGC ESPCEPCC
