ID   KRA31_SHEEP             Reviewed;          98 AA.
AC   P02446;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   03-AUG-2022, entry version 61.
DE   RecName: Full=Keratin-associated protein 3-1;
DE   AltName: Full=Keratin, high sulfur matrix protein, IIIB2;
GN   Name=KRTAP3-1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE OF 2-98.
RC   STRAIN=Merino;
RA   Haylett T., Swart L.S.;
RT   "Studies on the high-sulfur proteins of reduced merino wool. Part III: the
RT   amino-acid sequence of protein SCMKB-IIIB2.";
RL   Text. Res. J. 39:917-929(1969).
RN   [2]
RP   PROTEIN SEQUENCE OF 2-98, AND ACETYLATION AT ALA-2.
RX   PubMed=4678578; DOI=10.1042/bj1281229;
RA   Elleman T.C.;
RT   "The amino acid sequence of protein SCMK-B2C from the high-sulphur fraction
RT   of wool keratin.";
RL   Biochem. J. 128:1229-1239(1972).
CC   -!- FUNCTION: In the wool cortex, wool keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant wool shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of wool keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with wool keratins.
CC   -!- TISSUE SPECIFICITY: Wool.
CC   -!- SIMILARITY: Belongs to the KRTAP type 3 family. {ECO:0000305}.
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DR   PIR; A94304; KRSHH2.
DR   AlphaFoldDB; P02446; -.
DR   iPTMnet; P02446; -.
DR   PRIDE; P02446; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR007659; Keratin_matx.
DR   PANTHER; PTHR23260; PTHR23260; 1.
DR   Pfam; PF04579; Keratin_matx; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Keratin; Reference proteome;
KW   Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000269|PubMed:4678578"
FT   CHAIN           2..98
FT                   /note="Keratin-associated protein 3-1"
FT                   /id="PRO_0000185165"
FT   REPEAT          3..7
FT                   /note="1"
FT   REPEAT          8..12
FT                   /note="2"
FT   REPEAT          47..51
FT                   /note="3"
FT   REPEAT          55..59
FT                   /note="4"
FT   REGION          3..59
FT                   /note="4 X 5 AA repeats of C-C-X(3)"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:4678578"
FT   VARIANT         65
FT                   /note="C -> T"
SQ   SEQUENCE   98 AA;  10420 MW;  7AFBCFB1C3F5DF67 CRC64;
     MACCAPRCCS VRTGPATTIC SSDKFCRCGV CLPSTCPHNI SLLQPTCCDN SPVPCVYPDT
     YVPTCFLLNS SHPTPGLSGI NLTTFIQPGC ENVCEPRC