KRA32_HUMAN
ID KRA32_HUMAN Reviewed; 98 AA.
AC Q9BYR7;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 134.
DE RecName: Full=Keratin-associated protein 3-2;
DE AltName: Full=High sulfur keratin-associated protein 3.2;
DE AltName: Full=Keratin-associated protein 3.2;
GN Name=KRTAP3-2; Synonyms=KAP3.2, KRTAP3.2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q9BYR7; O43184-4: ADAM12; NbExp=3; IntAct=EBI-751260, EBI-12006944;
CC Q9BYR7; P82987: ADAMTSL3; NbExp=3; IntAct=EBI-751260, EBI-10221726;
CC Q9BYR7; P29972: AQP1; NbExp=3; IntAct=EBI-751260, EBI-745213;
CC Q9BYR7; Q8N6T3: ARFGAP1; NbExp=3; IntAct=EBI-751260, EBI-716933;
CC Q9BYR7; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-751260, EBI-12006308;
CC Q9BYR7; A6NFR6-4: C5orf60; NbExp=3; IntAct=EBI-751260, EBI-10173955;
CC Q9BYR7; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-751260, EBI-744545;
CC Q9BYR7; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-751260, EBI-12139335;
CC Q9BYR7; Q8TCT0: CERK; NbExp=3; IntAct=EBI-751260, EBI-10274247;
CC Q9BYR7; Q8NE01: CNNM3; NbExp=3; IntAct=EBI-751260, EBI-741032;
CC Q9BYR7; Q8NE01-3: CNNM3; NbExp=3; IntAct=EBI-751260, EBI-10269984;
CC Q9BYR7; P27658: COL8A1; NbExp=3; IntAct=EBI-751260, EBI-747133;
CC Q9BYR7; Q02930-3: CREB5; NbExp=8; IntAct=EBI-751260, EBI-10192698;
CC Q9BYR7; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-751260, EBI-746300;
CC Q9BYR7; Q9Y6W6: DUSP10; NbExp=3; IntAct=EBI-751260, EBI-3443946;
CC Q9BYR7; O95967: EFEMP2; NbExp=3; IntAct=EBI-751260, EBI-743414;
CC Q9BYR7; Q8NEG0: FAM71C; NbExp=3; IntAct=EBI-751260, EBI-752049;
CC Q9BYR7; O60548: FOXD2; NbExp=3; IntAct=EBI-751260, EBI-17282008;
CC Q9BYR7; O43559: FRS3; NbExp=3; IntAct=EBI-751260, EBI-725515;
CC Q9BYR7; A0A0S2Z4D9: GAD1; NbExp=3; IntAct=EBI-751260, EBI-16430771;
CC Q9BYR7; P15976-2: GATA1; NbExp=3; IntAct=EBI-751260, EBI-9090198;
CC Q9BYR7; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-751260, EBI-11978177;
CC Q9BYR7; A0A024R5S0: hCG_2003792; NbExp=3; IntAct=EBI-751260, EBI-10188461;
CC Q9BYR7; P49639: HOXA1; NbExp=6; IntAct=EBI-751260, EBI-740785;
CC Q9BYR7; P17482: HOXB9; NbExp=3; IntAct=EBI-751260, EBI-745290;
CC Q9BYR7; Q12891: HYAL2; NbExp=3; IntAct=EBI-751260, EBI-2806068;
CC Q9BYR7; P18084: ITGB5; NbExp=3; IntAct=EBI-751260, EBI-1223434;
CC Q9BYR7; Q9Y6Z4: KIF25-AS1; NbExp=3; IntAct=EBI-751260, EBI-10329963;
CC Q9BYR7; Q5T749: KPRP; NbExp=3; IntAct=EBI-751260, EBI-10981970;
CC Q9BYR7; P60370: KRTAP10-5; NbExp=6; IntAct=EBI-751260, EBI-10172150;
CC Q9BYR7; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-751260, EBI-10171774;
CC Q9BYR7; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-751260, EBI-10210845;
CC Q9BYR7; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-751260, EBI-10176379;
CC Q9BYR7; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-751260, EBI-10241252;
CC Q9BYR7; Q3LI76: KRTAP15-1; NbExp=5; IntAct=EBI-751260, EBI-11992140;
CC Q9BYR7; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-751260, EBI-3957672;
CC Q9BYR7; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-751260, EBI-11958132;
CC Q9BYR7; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-751260, EBI-1044640;
CC Q9BYR7; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-751260, EBI-1043191;
CC Q9BYR7; Q14847-2: LASP1; NbExp=3; IntAct=EBI-751260, EBI-9088686;
CC Q9BYR7; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-751260, EBI-11962058;
CC Q9BYR7; Q5T7P3: LCE1B; NbExp=8; IntAct=EBI-751260, EBI-10245913;
CC Q9BYR7; Q5T754: LCE1F; NbExp=3; IntAct=EBI-751260, EBI-11958008;
CC Q9BYR7; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-751260, EBI-10246607;
CC Q9BYR7; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-751260, EBI-9394625;
CC Q9BYR7; Q5T5A8: LCE3C; NbExp=8; IntAct=EBI-751260, EBI-10245291;
CC Q9BYR7; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-751260, EBI-6658837;
CC Q9BYR7; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-751260, EBI-10245456;
CC Q9BYR7; Q5TA78: LCE4A; NbExp=6; IntAct=EBI-751260, EBI-10246358;
CC Q9BYR7; Q9Y2E5: MAN2B2; NbExp=3; IntAct=EBI-751260, EBI-12243024;
CC Q9BYR7; O60336: MAPKBP1; NbExp=3; IntAct=EBI-751260, EBI-947402;
CC Q9BYR7; Q6NSM0: NR1D2; NbExp=3; IntAct=EBI-751260, EBI-10250949;
CC Q9BYR7; Q9P121: NTM; NbExp=4; IntAct=EBI-751260, EBI-4315078;
CC Q9BYR7; Q7Z417: NUFIP2; NbExp=6; IntAct=EBI-751260, EBI-1210753;
CC Q9BYR7; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-751260, EBI-10225049;
CC Q9BYR7; P32242: OTX1; NbExp=9; IntAct=EBI-751260, EBI-740446;
CC Q9BYR7; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-751260, EBI-11956269;
CC Q9BYR7; Q9NRY6: PLSCR3; NbExp=3; IntAct=EBI-751260, EBI-750734;
CC Q9BYR7; Q7Z3K3: POGZ; NbExp=3; IntAct=EBI-751260, EBI-1389308;
CC Q9BYR7; Q12837: POU4F2; NbExp=5; IntAct=EBI-751260, EBI-17236143;
CC Q9BYR7; Q7Z5V6-2: PPP1R32; NbExp=3; IntAct=EBI-751260, EBI-12000762;
CC Q9BYR7; Q9NV39: PRR34; NbExp=3; IntAct=EBI-751260, EBI-11959565;
CC Q9BYR7; Q9Y2K5-2: R3HDM2; NbExp=3; IntAct=EBI-751260, EBI-10326419;
CC Q9BYR7; Q86YT5: SLC13A5; NbExp=3; IntAct=EBI-751260, EBI-12002412;
CC Q9BYR7; Q92922: SMARCC1; NbExp=3; IntAct=EBI-751260, EBI-355653;
CC Q9BYR7; O43609: SPRY1; NbExp=3; IntAct=EBI-751260, EBI-3866665;
CC Q9BYR7; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-751260, EBI-5235829;
CC Q9BYR7; Q6EMK4: VASN; NbExp=3; IntAct=EBI-751260, EBI-10249550;
CC Q9BYR7; Q9GZM5: YIPF3; NbExp=7; IntAct=EBI-751260, EBI-743787;
CC Q9BYR7; Q15915: ZIC1; NbExp=3; IntAct=EBI-751260, EBI-11963196;
CC Q9BYR7; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-751260, EBI-11962760;
CC Q9BYR7; Q9NWL9; NbExp=3; IntAct=EBI-751260, EBI-10315054;
CC Q9BYR7; P09022: Hoxa1; Xeno; NbExp=4; IntAct=EBI-751260, EBI-3957603;
CC -!- SIMILARITY: Belongs to the KRTAP type 3 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ406932; CAC27571.1; -; mRNA.
DR EMBL; BC034582; AAH34582.1; -; mRNA.
DR CCDS; CCDS32644.1; -.
DR RefSeq; NP_114165.1; NM_031959.2.
DR AlphaFoldDB; Q9BYR7; -.
DR BioGRID; 123808; 79.
DR IntAct; Q9BYR7; 75.
DR STRING; 9606.ENSP00000375429; -.
DR BioMuta; KRTAP3-2; -.
DR DMDM; 38372628; -.
DR MassIVE; Q9BYR7; -.
DR PaxDb; Q9BYR7; -.
DR PeptideAtlas; Q9BYR7; -.
DR PRIDE; Q9BYR7; -.
DR ProteomicsDB; 79696; -.
DR Antibodypedia; 74180; 37 antibodies from 9 providers.
DR DNASU; 83897; -.
DR Ensembl; ENST00000391587.3; ENSP00000375429.1; ENSG00000212900.3.
DR Ensembl; ENST00000575409.2; ENSP00000459215.1; ENSG00000263296.2.
DR GeneID; 83897; -.
DR KEGG; hsa:83897; -.
DR MANE-Select; ENST00000391587.3; ENSP00000375429.1; NM_031959.3; NP_114165.1.
DR UCSC; uc002hvs.4; human.
DR CTD; 83897; -.
DR GeneCards; KRTAP3-2; -.
DR HGNC; HGNC:16779; KRTAP3-2.
DR HPA; ENSG00000212900; Tissue enriched (skin).
DR neXtProt; NX_Q9BYR7; -.
DR OpenTargets; ENSG00000212900; -.
DR PharmGKB; PA38419; -.
DR VEuPathDB; HostDB:ENSG00000212900; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00390000001157; -.
DR HOGENOM; CLU_2359185_0_0_1; -.
DR InParanoid; Q9BYR7; -.
DR OMA; SAIRYCC; -.
DR OrthoDB; 1591683at2759; -.
DR PhylomeDB; Q9BYR7; -.
DR TreeFam; TF338042; -.
DR PathwayCommons; Q9BYR7; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q9BYR7; -.
DR BioGRID-ORCS; 83897; 9 hits in 987 CRISPR screens.
DR GenomeRNAi; 83897; -.
DR Pharos; Q9BYR7; Tdark.
DR PRO; PR:Q9BYR7; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9BYR7; protein.
DR Bgee; ENSG00000212900; Expressed in lower esophagus mucosa and 50 other tissues.
DR Genevisible; Q9BYR7; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR007659; Keratin_matx.
DR PANTHER; PTHR23260; PTHR23260; 1.
DR Pfam; PF04579; Keratin_matx; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..98
FT /note="Keratin-associated protein 3-2"
FT /id="PRO_0000185166"
FT REPEAT 3..7
FT /note="1"
FT REPEAT 47..51
FT /note="2"
FT REPEAT 89..93
FT /note="3"
FT REGION 3..59
FT /note="3 X 5 AA repeats of C-C-X(3)"
FT VARIANT 8
FT /note="S -> G (in dbSNP:rs9897046)"
FT /id="VAR_053454"
FT VARIANT 27
FT /note="R -> C (in dbSNP:rs3829598)"
FT /id="VAR_053455"
FT VARIANT 46
FT /note="I -> T (in dbSNP:rs3813050)"
FT /id="VAR_053456"
SQ SEQUENCE 98 AA; 10407 MW; C4C7C90DB6E016C7 CRC64;
MDCCASRSCS VPTGPATTIC SSDKSCRCGV CLPSTCPHTV WLLEPICCDN CPPPCHIPQP
CVPTCFLLNS CQPTPGLETL NLTTFTQPCC EPCLPRGC
