KRA32_MOUSE
ID KRA32_MOUSE Reviewed; 99 AA.
AC Q9D638; Q9CPW1;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 16-DEC-2008, sequence version 2.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Keratin-associated protein 3-2 {ECO:0000312|EMBL:CAM19193.1};
DE AltName: Full=Keratin-associated protein 3-3;
GN Name=Krtap3-2 {ECO:0000312|MGI:MGI:1913958};
GN Synonyms=Krtap3-3 {ECO:0000312|EMBL:CAM19194.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAB29484.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB29484.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAB22891.1},
RC Neonatal skin {ECO:0000312|EMBL:BAB29484.1}, and
RC Tongue {ECO:0000312|EMBL:BAB26727.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000312|EMBL:AAI17093.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the KRTAP type 3 family.
CC {ECO:0000250|UniProtKB:Q9BYR7}.
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DR EMBL; AK003615; BAB22891.1; -; mRNA.
DR EMBL; AK009410; BAB26270.1; -; mRNA.
DR EMBL; AK010142; BAB26727.1; -; mRNA.
DR EMBL; AK014641; BAB29484.1; -; mRNA.
DR EMBL; AL591417; CAM19193.1; -; Genomic_DNA.
DR EMBL; AL591417; CAM19194.1; -; Genomic_DNA.
DR EMBL; BC117058; AAI17059.1; -; mRNA.
DR EMBL; BC117092; AAI17093.1; -; mRNA.
DR EMBL; BC120760; AAI20761.1; -; mRNA.
DR EMBL; BC120762; AAI20763.1; -; mRNA.
DR CCDS; CCDS25385.1; -.
DR CCDS; CCDS25386.1; -.
DR RefSeq; NP_079800.1; NM_025524.2.
DR RefSeq; NP_079996.2; NM_025720.3.
DR AlphaFoldDB; Q9D638; -.
DR STRING; 10090.ENSMUSP00000090373; -.
DR PhosphoSitePlus; Q9D638; -.
DR PaxDb; Q9D638; -.
DR DNASU; 66708; -.
DR Ensembl; ENSMUST00000092699; ENSMUSP00000090373; ENSMUSG00000069721.
DR Ensembl; ENSMUST00000092700; ENSMUSP00000090374; ENSMUSG00000069722.
DR GeneID; 66380; -.
DR GeneID; 66708; -.
DR KEGG; mmu:66380; -.
DR KEGG; mmu:66708; -.
DR UCSC; uc007liz.1; mouse.
DR CTD; 83897; -.
DR CTD; 85293; -.
DR MGI; MGI:1913958; Krtap3-2.
DR VEuPathDB; HostDB:ENSMUSG00000069721; -.
DR VEuPathDB; HostDB:ENSMUSG00000069722; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00390000001157; -.
DR HOGENOM; CLU_2359185_0_0_1; -.
DR InParanoid; Q9D638; -.
DR OMA; PCIPRNC; -.
DR OrthoDB; 1591683at2759; -.
DR PhylomeDB; Q9D638; -.
DR TreeFam; TF338042; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR BioGRID-ORCS; 66380; 1 hit in 32 CRISPR screens.
DR BioGRID-ORCS; 66708; 1 hit in 33 CRISPR screens.
DR PRO; PR:Q9D638; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q9D638; protein.
DR Bgee; ENSMUSG00000069721; Expressed in lip and 5 other tissues.
DR Genevisible; Q9D638; MM.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR007659; Keratin_matx.
DR PANTHER; PTHR23260; PTHR23260; 1.
DR Pfam; PF04579; Keratin_matx; 1.
PE 3: Inferred from homology;
KW Acetylation; Keratin; Reference proteome; Repeat.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P02447"
FT CHAIN 2..99
FT /note="Keratin-associated protein 3-2"
FT /id="PRO_0000358595"
FT REPEAT 3..7
FT /note="1"
FT /evidence="ECO:0000255"
FT REPEAT 8..12
FT /note="2"
FT /evidence="ECO:0000255"
FT REPEAT 47..51
FT /note="3"
FT /evidence="ECO:0000255"
FT REGION 3..59
FT /note="3 X 5 AA repeats of C-C-X(3)"
FT /evidence="ECO:0000255"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:P02447"
FT CONFLICT 13
FT /note="T -> A (in Ref. 1; BAB29484)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 99 AA; 10574 MW; F0E5542FA890302B CRC64;
MACCVARCCS VPTGPATTIC SSDKSCRCGV CLPSTCPHTI WQLEPTCCDN CPPPCHIPQP
CVPTCFLLNS CHPTPDLLTV NLTTYVQPGC EEPCVPRCC
