ID   KRA32_SHEEP             Reviewed;          98 AA.
AC   Q6S343; Q28577;
DT   16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 52.
DE   RecName: Full=Keratin-associated protein 3-2 {ECO:0000250|UniProtKB:Q9BYR7};
DE   AltName: Full=BIIIB2 high-sulfur keratin {ECO:0000312|EMBL:AAA31540.1};
DE   AltName: Full=High sulfur keratin IF-associated protein 3.2 {ECO:0000312|EMBL:AAR82895.1};
GN   Name=KAP3.2 {ECO:0000312|EMBL:AAR82895.1};
GN   Synonyms=BIIIB2 {ECO:0000303|PubMed:2472352};
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1] {ECO:0000312|EMBL:AAA31540.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Wool follicle {ECO:0000269|PubMed:2472352};
RX   PubMed=2472352; DOI=10.1016/0888-7543(89)90298-x;
RA   Frenkel M.J., Powell B.C., Ward K.A., Sleigh M.J., Rogers G.E.;
RT   "The keratin BIIIB gene family: isolation of cDNA clones and structure of a
RT   gene and a related pseudogene.";
RL   Genomics 4:182-191(1989).
RN   [2] {ECO:0000312|EMBL:AAR82895.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Itenge T.O., Hickford J.G.H., Forrest R.;
RT   "The sequence of sheep keratin intermediate filament-associated protein
RT   (KAP3.2) gene.";
RL   Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000305}
RP   TISSUE SPECIFICITY.
RX   PubMed=10594723; DOI=10.1046/j.1523-1747.1999.00775.x;
RA   Rufaut N.W., Pearson A.J., Nixon A.J., Wheeler T.T., Wilkins R.J.;
RT   "Identification of differentially expressed genes during a wool follicle
RT   growth cycle induced by prolactin.";
RL   J. Invest. Dermatol. 113:865-872(1999).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Localized to the cortical keratogenous zone in wool
CC       follicle. {ECO:0000269|PubMed:10594723}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 3 family.
CC       {ECO:0000250|UniProtKB:Q9BYR7}.
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DR   EMBL; M21099; AAA31540.1; -; Genomic_DNA.
DR   EMBL; AY483216; AAR82895.1; -; Genomic_DNA.
DR   PIR; I47083; I47083.
DR   AlphaFoldDB; Q6S343; -.
DR   STRING; 9940.ENSOARP00000000067; -.
DR   PRIDE; Q6S343; -.
DR   Ensembl; ENSOART00000000092; ENSOARP00000000067; ENSOARG00000000091.
DR   Ensembl; ENSOART00020009927; ENSOARP00020008204; ENSOARG00020006425.
DR   eggNOG; KOG4726; Eukaryota.
DR   HOGENOM; CLU_2359185_0_0_1; -.
DR   OMA; CCEPDTY; -.
DR   Proteomes; UP000002356; Chromosome 11.
DR   Bgee; ENSOARG00000000091; Expressed in ruminant reticulum.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR007659; Keratin_matx.
DR   PANTHER; PTHR23260; PTHR23260; 1.
DR   Pfam; PF04579; Keratin_matx; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Keratin; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:P02447"
FT   CHAIN           2..98
FT                   /note="Keratin-associated protein 3-2"
FT                   /id="PRO_0000358596"
FT   REPEAT          3..7
FT                   /note="1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          8..12
FT                   /note="2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          47..51
FT                   /note="3"
FT                   /evidence="ECO:0000255"
FT   REGION          3..59
FT                   /note="3 X 5 AA repeats of C-C-X(3)"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         2
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000250|UniProtKB:P02447"
FT   CONFLICT        35
FT                   /note="T -> S (in Ref. 1; AAA31540)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        76
FT                   /note="G -> R (in Ref. 1; AAA31540)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        89
FT                   /note="G -> R (in Ref. 1; AAA31540)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   98 AA;  10421 MW;  7AF7FF74F936D56D CRC64;
     MACCAPRCCS VRTGPATTIC SSDKFCRCGV CLPSTCPHDI SLLQPTCCDN SPVPCYVPDT
     YVPTCFLLNS SHPTPGLSGI NLTTFIQPGC ENVCEPRC