KRA33_HUMAN
ID KRA33_HUMAN Reviewed; 98 AA.
AC Q9BYR6; Q52LP0; Q6NTD4;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 126.
DE RecName: Full=Keratin-associated protein 3-3;
DE AltName: Full=High sulfur keratin-associated protein 3.3;
DE AltName: Full=Keratin-associated protein 3.3;
GN Name=KRTAP3-3; Synonyms=KAP3.3, KRTAP3.3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q9BYR6; P43353: ALDH3B1; NbExp=3; IntAct=EBI-3957694, EBI-2558314;
CC Q9BYR6; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-3957694, EBI-12224467;
CC Q9BYR6; Q03989: ARID5A; NbExp=3; IntAct=EBI-3957694, EBI-948603;
CC Q9BYR6; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-3957694, EBI-12006308;
CC Q9BYR6; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-3957694, EBI-745073;
CC Q9BYR6; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-3957694, EBI-12139335;
CC Q9BYR6; Q5T4B2: CERCAM; NbExp=3; IntAct=EBI-3957694, EBI-12261896;
CC Q9BYR6; Q9UBR2: CTSZ; NbExp=3; IntAct=EBI-3957694, EBI-8636823;
CC Q9BYR6; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-3957694, EBI-3867333;
CC Q9BYR6; Q8TF63: DCANP1; NbExp=3; IntAct=EBI-3957694, EBI-10275670;
CC Q9BYR6; A2VCK2: DCDC2B; NbExp=3; IntAct=EBI-3957694, EBI-10173222;
CC Q9BYR6; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-3957694, EBI-9679045;
CC Q9BYR6; Q92608: DOCK2; NbExp=3; IntAct=EBI-3957694, EBI-448771;
CC Q9BYR6; Q96PL5: ERMAP; NbExp=3; IntAct=EBI-3957694, EBI-13361852;
CC Q9BYR6; Q8N9I5: FADS6; NbExp=3; IntAct=EBI-3957694, EBI-3943864;
CC Q9BYR6; Q92567-2: FAM168A; NbExp=3; IntAct=EBI-3957694, EBI-11978259;
CC Q9BYR6; O95363: FARS2; NbExp=3; IntAct=EBI-3957694, EBI-2513774;
CC Q9BYR6; Q99958: FOXC2; NbExp=3; IntAct=EBI-3957694, EBI-3956892;
CC Q9BYR6; O75593: FOXH1; NbExp=3; IntAct=EBI-3957694, EBI-1759806;
CC Q9BYR6; Q9BZS1: FOXP3; NbExp=3; IntAct=EBI-3957694, EBI-983719;
CC Q9BYR6; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-3957694, EBI-11975289;
CC Q9BYR6; Q13227: GPS2; NbExp=3; IntAct=EBI-3957694, EBI-713355;
CC Q9BYR6; P09211: GSTP1; NbExp=3; IntAct=EBI-3957694, EBI-353467;
CC Q9BYR6; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-3957694, EBI-11978177;
CC Q9BYR6; A0A024R5S0: hCG_2003792; NbExp=3; IntAct=EBI-3957694, EBI-10188461;
CC Q9BYR6; P49639: HOXA1; NbExp=3; IntAct=EBI-3957694, EBI-740785;
CC Q9BYR6; O43593: HR; NbExp=3; IntAct=EBI-3957694, EBI-2880706;
CC Q9BYR6; Q2WGJ6: KLHL38; NbExp=3; IntAct=EBI-3957694, EBI-6426443;
CC Q9BYR6; P78385: KRT83; NbExp=5; IntAct=EBI-3957694, EBI-10221390;
CC Q9BYR6; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-3957694, EBI-11953334;
CC Q9BYR6; P60329: KRTAP12-4; NbExp=3; IntAct=EBI-3957694, EBI-10176396;
CC Q9BYR6; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-3957694, EBI-11953846;
CC Q9BYR6; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-3957694, EBI-11992140;
CC Q9BYR6; Q3LHN2: KRTAP19-2; NbExp=3; IntAct=EBI-3957694, EBI-12196745;
CC Q9BYR6; Q3SYF9: KRTAP19-7; NbExp=3; IntAct=EBI-3957694, EBI-10241353;
CC Q9BYR6; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-3957694, EBI-10302392;
CC Q9BYR6; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-3957694, EBI-10172511;
CC Q9BYR6; Q6L8G9: KRTAP5-6; NbExp=3; IntAct=EBI-3957694, EBI-10250562;
CC Q9BYR6; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-3957694, EBI-11962084;
CC Q9BYR6; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-3957694, EBI-1043191;
CC Q9BYR6; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-3957694, EBI-11958364;
CC Q9BYR6; Q14847-2: LASP1; NbExp=3; IntAct=EBI-3957694, EBI-9088686;
CC Q9BYR6; Q5T754: LCE1F; NbExp=3; IntAct=EBI-3957694, EBI-11958008;
CC Q9BYR6; O14633: LCE2B; NbExp=3; IntAct=EBI-3957694, EBI-11478468;
CC Q9BYR6; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-3957694, EBI-9394625;
CC Q9BYR6; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-3957694, EBI-10245291;
CC Q9BYR6; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-3957694, EBI-6658837;
CC Q9BYR6; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-3957694, EBI-10245456;
CC Q9BYR6; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-3957694, EBI-10246358;
CC Q9BYR6; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-3957694, EBI-2341787;
CC Q9BYR6; Q8WUT4: LRRN4; NbExp=3; IntAct=EBI-3957694, EBI-745046;
CC Q9BYR6; Q16540: MRPL23; NbExp=3; IntAct=EBI-3957694, EBI-1046141;
CC Q9BYR6; Q9BW11: MXD3; NbExp=3; IntAct=EBI-3957694, EBI-741574;
CC Q9BYR6; Q6NSM0: NR1D2; NbExp=3; IntAct=EBI-3957694, EBI-10250949;
CC Q9BYR6; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-3957694, EBI-741158;
CC Q9BYR6; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-3957694, EBI-1210753;
CC Q9BYR6; A8MYP8: ODF3B; NbExp=3; IntAct=EBI-3957694, EBI-12010090;
CC Q9BYR6; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-3957694, EBI-10225049;
CC Q9BYR6; P32242: OTX1; NbExp=6; IntAct=EBI-3957694, EBI-740446;
CC Q9BYR6; Q15077: P2RY6; NbExp=3; IntAct=EBI-3957694, EBI-10235794;
CC Q9BYR6; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-3957694, EBI-11022007;
CC Q9BYR6; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-3957694, EBI-14084211;
CC Q9BYR6; P78337: PITX1; NbExp=3; IntAct=EBI-3957694, EBI-748265;
CC Q9BYR6; Q99697-2: PITX2; NbExp=3; IntAct=EBI-3957694, EBI-12138495;
CC Q9BYR6; Q9NRY6: PLSCR3; NbExp=3; IntAct=EBI-3957694, EBI-750734;
CC Q9BYR6; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-3957694, EBI-769257;
CC Q9BYR6; O43741: PRKAB2; NbExp=3; IntAct=EBI-3957694, EBI-1053424;
CC Q9BYR6; P15151: PVR; NbExp=3; IntAct=EBI-3957694, EBI-3919694;
CC Q9BYR6; Q6ZSJ9: SHISA6; NbExp=3; IntAct=EBI-3957694, EBI-12037847;
CC Q9BYR6; Q92922: SMARCC1; NbExp=3; IntAct=EBI-3957694, EBI-355653;
CC Q9BYR6; Q9NP84: TNFRSF12A; NbExp=3; IntAct=EBI-3957694, EBI-2851995;
CC Q9BYR6; O95231: VENTX; NbExp=3; IntAct=EBI-3957694, EBI-10191303;
CC Q9BYR6; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-3957694, EBI-11957216;
CC Q9BYR6; Q96F45: ZNF503; NbExp=3; IntAct=EBI-3957694, EBI-8832437;
CC -!- TISSUE SPECIFICITY: Localized to the upper cortex of the hair shaft.
CC {ECO:0000269|PubMed:11279113}.
CC -!- SIMILARITY: Belongs to the KRTAP type 3 family. {ECO:0000305}.
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DR EMBL; AJ406933; CAC27572.1; -; mRNA.
DR EMBL; BC069099; AAH69099.1; -; mRNA.
DR EMBL; BC069448; AAH69448.1; -; mRNA.
DR EMBL; BC093845; AAH93845.1; -; mRNA.
DR EMBL; BC093847; AAH93847.1; -; mRNA.
DR CCDS; CCDS32643.1; -.
DR RefSeq; NP_149441.1; NM_033185.2.
DR AlphaFoldDB; Q9BYR6; -.
DR BioGRID; 124457; 80.
DR IntAct; Q9BYR6; 75.
DR STRING; 9606.ENSP00000375428; -.
DR iPTMnet; Q9BYR6; -.
DR PhosphoSitePlus; Q9BYR6; -.
DR BioMuta; KRTAP3-3; -.
DR DMDM; 48474631; -.
DR MassIVE; Q9BYR6; -.
DR PaxDb; Q9BYR6; -.
DR PeptideAtlas; Q9BYR6; -.
DR PRIDE; Q9BYR6; -.
DR ProteomicsDB; 79695; -.
DR Antibodypedia; 63700; 48 antibodies from 10 providers.
DR DNASU; 85293; -.
DR Ensembl; ENST00000391586.3; ENSP00000375428.1; ENSG00000212899.3.
DR Ensembl; ENST00000572132.2; ENSP00000458618.1; ENSG00000263101.2.
DR GeneID; 85293; -.
DR KEGG; hsa:85293; -.
DR MANE-Select; ENST00000391586.3; ENSP00000375428.1; NM_033185.3; NP_149441.1.
DR UCSC; uc002hvr.1; human.
DR CTD; 85293; -.
DR DisGeNET; 85293; -.
DR GeneCards; KRTAP3-3; -.
DR HGNC; HGNC:18890; KRTAP3-3.
DR HPA; ENSG00000212899; Tissue enriched (skin).
DR neXtProt; NX_Q9BYR6; -.
DR OpenTargets; ENSG00000212899; -.
DR PharmGKB; PA38742; -.
DR VEuPathDB; HostDB:ENSG00000212899; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00390000001157; -.
DR HOGENOM; CLU_2359185_0_0_1; -.
DR InParanoid; Q9BYR6; -.
DR OMA; PCIPRNC; -.
DR OrthoDB; 1591683at2759; -.
DR PhylomeDB; Q9BYR6; -.
DR TreeFam; TF338042; -.
DR PathwayCommons; Q9BYR6; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q9BYR6; -.
DR BioGRID-ORCS; 85293; 8 hits in 986 CRISPR screens.
DR GenomeRNAi; 85293; -.
DR Pharos; Q9BYR6; Tdark.
DR PRO; PR:Q9BYR6; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9BYR6; protein.
DR Bgee; ENSG00000212899; Expressed in skin of abdomen and 62 other tissues.
DR Genevisible; Q9BYR6; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR007659; Keratin_matx.
DR PANTHER; PTHR23260; PTHR23260; 1.
DR Pfam; PF04579; Keratin_matx; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..98
FT /note="Keratin-associated protein 3-3"
FT /id="PRO_0000185167"
FT REPEAT 3..7
FT /note="1"
FT REPEAT 47..51
FT /note="2"
FT REPEAT 89..93
FT /note="3"
FT REGION 3..59
FT /note="3 X 5 AA repeats of C-C-X(3)"
FT CONFLICT 90
FT /note="C -> Y (in Ref. 2; AAH69099)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 98 AA; 10365 MW; 9807DC59B72799AB CRC64;
MDCCASRGCS VPTGPATTIC SSDKSCRCGV CLPSTCPHTV WLLEPTCCDN CPPPCHIPQP
CVPTCFLLNS CQPTPGLETL NLTTFTQPCC EPCLPRGC
