ID   KRA34_SHEEP             Reviewed;          98 AA.
AC   P02445;
DT   21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT   21-JUL-1986, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Keratin, high sulfur matrix protein, IIIB4;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   PROTEIN SEQUENCE, AND ACETYLATION AT ALA-1.
RC   STRAIN=Merino;
RX   PubMed=4942536; DOI=10.1042/bj1230201;
RA   Swart L.S., Haylett T.;
RT   "Studies on the high-sulphur proteins of reduced merino wool. Amino acid
RT   sequence of protein SCMKB-3B 4.";
RL   Biochem. J. 123:201-210(1971).
CC   -!- FUNCTION: In the wool cortex, wool keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant wool shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of wool keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with wool keratins.
CC   -!- TISSUE SPECIFICITY: Wool.
CC   -!- SIMILARITY: Belongs to the KRTAP type 3 family. {ECO:0000305}.
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DR   PIR; A02843; KRSHH4.
DR   AlphaFoldDB; P02445; -.
DR   STRING; 9940.ENSOARP00000004800; -.
DR   iPTMnet; P02445; -.
DR   eggNOG; KOG4726; Eukaryota.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   InterPro; IPR007659; Keratin_matx.
DR   PANTHER; PTHR23260; PTHR23260; 1.
DR   Pfam; PF04579; Keratin_matx; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Keratin; Reference proteome.
FT   CHAIN           1..98
FT                   /note="Keratin, high sulfur matrix protein, IIIB4"
FT                   /id="PRO_0000185169"
FT   MOD_RES         1
FT                   /note="N-acetylalanine"
FT                   /evidence="ECO:0000269|PubMed:4942536"
SQ   SEQUENCE   98 AA;  10472 MW;  28F00C1463B846F8 CRC64;
     ACCARLCCSV PTSPATTICS SDKFCRCGVC LPSTCPHTVW FLQPTCCCDN RPPPCHIPQP
     SVPTCFLLNS SQPTPGLESI NLTTYTQPSC EPCIPSCC