KRA42_HUMAN
ID KRA42_HUMAN Reviewed; 136 AA.
AC Q9BYR5; A0JP64;
DT 24-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 136.
DE RecName: Full=Keratin-associated protein 4-2;
DE AltName: Full=Keratin-associated protein 4.2;
DE AltName: Full=Ultrahigh sulfur keratin-associated protein 4.2;
GN Name=KRTAP4-2; Synonyms=KAP4.2, KRTAP4.2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT CYS-95.
RC TISSUE=Scalp;
RX PubMed=11279113; DOI=10.1074/jbc.m100657200;
RA Rogers M.A., Langbein L., Winter H., Ehmann C., Praetzel S., Korn B.,
RA Schweizer J.;
RT "Characterization of a cluster of human high/ultrahigh sulfur keratin-
RT associated protein genes embedded in the type I keratin gene domain on
RT chromosome 17q12-21.";
RL J. Biol. Chem. 276:19440-19451(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16625196; DOI=10.1038/nature04689;
RA Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT human lineage.";
RL Nature 440:1045-1049(2006).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT CYS-95.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q9BYR5; Q6UY14-3: ADAMTSL4; NbExp=6; IntAct=EBI-10172511, EBI-10173507;
CC Q9BYR5; Q9Y2J4-4: AMOTL2; NbExp=3; IntAct=EBI-10172511, EBI-10187270;
CC Q9BYR5; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-10172511, EBI-11954519;
CC Q9BYR5; P29972: AQP1; NbExp=6; IntAct=EBI-10172511, EBI-745213;
CC Q9BYR5; Q7Z3C6: ATG9A; NbExp=3; IntAct=EBI-10172511, EBI-727146;
CC Q9BYR5; Q5T686: AVPI1; NbExp=3; IntAct=EBI-10172511, EBI-8640233;
CC Q9BYR5; A0A0S2Z4M1: AXIN1; NbExp=3; IntAct=EBI-10172511, EBI-16429430;
CC Q9BYR5; O15169: AXIN1; NbExp=3; IntAct=EBI-10172511, EBI-710484;
CC Q9BYR5; O95429: BAG4; NbExp=3; IntAct=EBI-10172511, EBI-2949658;
CC Q9BYR5; Q13895: BYSL; NbExp=3; IntAct=EBI-10172511, EBI-358049;
CC Q9BYR5; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-10172511, EBI-744545;
CC Q9BYR5; Q8TC90: CCER1; NbExp=3; IntAct=EBI-10172511, EBI-746041;
CC Q9BYR5; Q8N6W0: CELF5; NbExp=3; IntAct=EBI-10172511, EBI-12139335;
CC Q9BYR5; Q9UKJ5: CHIC2; NbExp=3; IntAct=EBI-10172511, EBI-741528;
CC Q9BYR5; Q9H2X0: CHRD; NbExp=6; IntAct=EBI-10172511, EBI-947551;
CC Q9BYR5; Q9UGL9: CRCT1; NbExp=7; IntAct=EBI-10172511, EBI-713677;
CC Q9BYR5; Q02930-3: CREB5; NbExp=9; IntAct=EBI-10172511, EBI-10192698;
CC Q9BYR5; Q49AN0: CRY2; NbExp=3; IntAct=EBI-10172511, EBI-2212355;
CC Q9BYR5; Q08AG9: CYP21A2; NbExp=3; IntAct=EBI-10172511, EBI-14156412;
CC Q9BYR5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-10172511, EBI-3867333;
CC Q9BYR5; Q9P1A6: DLGAP2; NbExp=3; IntAct=EBI-10172511, EBI-1753397;
CC Q9BYR5; Q92608: DOCK2; NbExp=3; IntAct=EBI-10172511, EBI-448771;
CC Q9BYR5; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-10172511, EBI-10247271;
CC Q9BYR5; O76003: GLRX3; NbExp=3; IntAct=EBI-10172511, EBI-374781;
CC Q9BYR5; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-10172511, EBI-11978177;
CC Q9BYR5; V9HW60: HEL-S-182mP; NbExp=3; IntAct=EBI-10172511, EBI-10180762;
CC Q9BYR5; P49639: HOXA1; NbExp=10; IntAct=EBI-10172511, EBI-740785;
CC Q9BYR5; P17482: HOXB9; NbExp=3; IntAct=EBI-10172511, EBI-745290;
CC Q9BYR5; P37235: HPCAL1; NbExp=3; IntAct=EBI-10172511, EBI-749311;
CC Q9BYR5; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-10172511, EBI-3918847;
CC Q9BYR5; P16144-2: ITGB4; NbExp=3; IntAct=EBI-10172511, EBI-11051601;
CC Q9BYR5; Q5T749: KPRP; NbExp=3; IntAct=EBI-10172511, EBI-10981970;
CC Q9BYR5; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10172511, EBI-11749135;
CC Q9BYR5; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-10172511, EBI-11741292;
CC Q9BYR5; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-10172511, EBI-10217483;
CC Q9BYR5; P60370: KRTAP10-5; NbExp=8; IntAct=EBI-10172511, EBI-10172150;
CC Q9BYR5; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-10172511, EBI-12012928;
CC Q9BYR5; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10172511, EBI-10172290;
CC Q9BYR5; P60410: KRTAP10-8; NbExp=10; IntAct=EBI-10172511, EBI-10171774;
CC Q9BYR5; P60411: KRTAP10-9; NbExp=5; IntAct=EBI-10172511, EBI-10172052;
CC Q9BYR5; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10172511, EBI-1052037;
CC Q9BYR5; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-10172511, EBI-10176379;
CC Q9BYR5; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10172511, EBI-11953334;
CC Q9BYR5; Q6PEX3: KRTAP26-1; NbExp=6; IntAct=EBI-10172511, EBI-3957672;
CC Q9BYR5; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-10172511, EBI-3957694;
CC Q9BYR5; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-10172511, EBI-10172511;
CC Q9BYR5; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-10172511, EBI-11958132;
CC Q9BYR5; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-10172511, EBI-11993254;
CC Q9BYR5; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-10172511, EBI-11958178;
CC Q9BYR5; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-10172511, EBI-11974251;
CC Q9BYR5; Q6L8G9: KRTAP5-6; NbExp=8; IntAct=EBI-10172511, EBI-10250562;
CC Q9BYR5; Q6L8G8: KRTAP5-7; NbExp=4; IntAct=EBI-10172511, EBI-11987425;
CC Q9BYR5; P26371: KRTAP5-9; NbExp=8; IntAct=EBI-10172511, EBI-3958099;
CC Q9BYR5; Q9BYQ4: KRTAP9-2; NbExp=8; IntAct=EBI-10172511, EBI-1044640;
CC Q9BYR5; Q9BYQ3: KRTAP9-3; NbExp=6; IntAct=EBI-10172511, EBI-1043191;
CC Q9BYR5; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-10172511, EBI-10185730;
CC Q9BYR5; Q9BYQ0: KRTAP9-8; NbExp=3; IntAct=EBI-10172511, EBI-11958364;
CC Q9BYR5; Q14847: LASP1; NbExp=3; IntAct=EBI-10172511, EBI-742828;
CC Q9BYR5; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-10172511, EBI-11962058;
CC Q9BYR5; Q5T7P3: LCE1B; NbExp=7; IntAct=EBI-10172511, EBI-10245913;
CC Q9BYR5; Q5T751: LCE1C; NbExp=3; IntAct=EBI-10172511, EBI-12224199;
CC Q9BYR5; Q5T752: LCE1D; NbExp=6; IntAct=EBI-10172511, EBI-11741311;
CC Q9BYR5; Q5T753: LCE1E; NbExp=3; IntAct=EBI-10172511, EBI-11955335;
CC Q9BYR5; Q5TA79: LCE2A; NbExp=6; IntAct=EBI-10172511, EBI-10246607;
CC Q9BYR5; O14633: LCE2B; NbExp=5; IntAct=EBI-10172511, EBI-11478468;
CC Q9BYR5; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-10172511, EBI-11973993;
CC Q9BYR5; Q5TA82: LCE2D; NbExp=6; IntAct=EBI-10172511, EBI-10246750;
CC Q9BYR5; Q5TA76: LCE3A; NbExp=4; IntAct=EBI-10172511, EBI-9394625;
CC Q9BYR5; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-10172511, EBI-11974495;
CC Q9BYR5; Q5T5A8: LCE3C; NbExp=6; IntAct=EBI-10172511, EBI-10245291;
CC Q9BYR5; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-10172511, EBI-6658837;
CC Q9BYR5; Q5T5B0: LCE3E; NbExp=6; IntAct=EBI-10172511, EBI-10245456;
CC Q9BYR5; Q5TA78: LCE4A; NbExp=6; IntAct=EBI-10172511, EBI-10246358;
CC Q9BYR5; Q5TCM9: LCE5A; NbExp=3; IntAct=EBI-10172511, EBI-11955689;
CC Q9BYR5; Q8TBB1: LNX1; NbExp=7; IntAct=EBI-10172511, EBI-739832;
CC Q9BYR5; Q9Y5Q3: MAFB; NbExp=3; IntAct=EBI-10172511, EBI-3649340;
CC Q9BYR5; P50222: MEOX2; NbExp=3; IntAct=EBI-10172511, EBI-748397;
CC Q9BYR5; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10172511, EBI-16439278;
CC Q9BYR5; Q9NQS3: NECTIN3; NbExp=3; IntAct=EBI-10172511, EBI-2826725;
CC Q9BYR5; Q9UBE8: NLK; NbExp=3; IntAct=EBI-10172511, EBI-366978;
CC Q9BYR5; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-10172511, EBI-945833;
CC Q9BYR5; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10172511, EBI-22310682;
CC Q9BYR5; Q6NSM0: NR1D2; NbExp=7; IntAct=EBI-10172511, EBI-10250949;
CC Q9BYR5; Q92570: NR4A3; NbExp=3; IntAct=EBI-10172511, EBI-13644623;
CC Q9BYR5; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10172511, EBI-741158;
CC Q9BYR5; Q7Z417: NUFIP2; NbExp=6; IntAct=EBI-10172511, EBI-1210753;
CC Q9BYR5; P32242: OTX1; NbExp=3; IntAct=EBI-10172511, EBI-740446;
CC Q9BYR5; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-10172511, EBI-12813389;
CC Q9BYR5; O76083: PDE9A; NbExp=3; IntAct=EBI-10172511, EBI-742764;
CC Q9BYR5; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-10172511, EBI-14084211;
CC Q9BYR5; Q13526: PIN1; NbExp=3; IntAct=EBI-10172511, EBI-714158;
CC Q9BYR5; O15162: PLSCR1; NbExp=3; IntAct=EBI-10172511, EBI-740019;
CC Q9BYR5; Q9NRQ2: PLSCR4; NbExp=3; IntAct=EBI-10172511, EBI-769257;
CC Q9BYR5; Q12837: POU4F2; NbExp=3; IntAct=EBI-10172511, EBI-17236143;
CC Q9BYR5; O43741: PRKAB2; NbExp=3; IntAct=EBI-10172511, EBI-1053424;
CC Q9BYR5; P54619: PRKAG1; NbExp=3; IntAct=EBI-10172511, EBI-1181439;
CC Q9BYR5; P60900: PSMA6; NbExp=3; IntAct=EBI-10172511, EBI-357793;
CC Q9BYR5; Q8WWW0: RASSF5; NbExp=3; IntAct=EBI-10172511, EBI-367390;
CC Q9BYR5; O76081: RGS20; NbExp=3; IntAct=EBI-10172511, EBI-1052678;
CC Q9BYR5; O76081-6: RGS20; NbExp=6; IntAct=EBI-10172511, EBI-10178530;
CC Q9BYR5; A0A0S2Z4U3: SDC3; NbExp=3; IntAct=EBI-10172511, EBI-10204280;
CC Q9BYR5; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10172511, EBI-10313866;
CC Q9BYR5; Q9UHI7: SLC23A1; NbExp=3; IntAct=EBI-10172511, EBI-1759386;
CC Q9BYR5; Q9UBX3: SLC25A10; NbExp=3; IntAct=EBI-10172511, EBI-750394;
CC Q9BYR5; P49901: SMCP; NbExp=3; IntAct=EBI-10172511, EBI-750494;
CC Q9BYR5; Q86W54: SPATA24; NbExp=3; IntAct=EBI-10172511, EBI-3916986;
CC Q9BYR5; O43609: SPRY1; NbExp=3; IntAct=EBI-10172511, EBI-3866665;
CC Q9BYR5; Q8N8B7: TCEANC; NbExp=3; IntAct=EBI-10172511, EBI-954696;
CC Q9BYR5; Q9GZM7-3: TINAGL1; NbExp=3; IntAct=EBI-10172511, EBI-10303636;
CC Q9BYR5; Q8IWZ5: TRIM42; NbExp=6; IntAct=EBI-10172511, EBI-5235829;
CC Q9BYR5; Q86UY0: TXNDC5; NbExp=3; IntAct=EBI-10172511, EBI-2825190;
CC Q9BYR5; Q06418: TYRO3; NbExp=3; IntAct=EBI-10172511, EBI-3951628;
CC Q9BYR5; Q6EMK4: VASN; NbExp=3; IntAct=EBI-10172511, EBI-10249550;
CC Q9BYR5; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-10172511, EBI-11957216;
CC Q9BYR5; P25490: YY1; NbExp=3; IntAct=EBI-10172511, EBI-765538;
CC Q9BYR5; O43167: ZBTB24; NbExp=3; IntAct=EBI-10172511, EBI-744471;
CC Q9BYR5; Q15973: ZNF124; NbExp=3; IntAct=EBI-10172511, EBI-2555767;
CC Q9BYR5; P17024: ZNF20; NbExp=3; IntAct=EBI-10172511, EBI-717634;
CC Q9BYR5; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-10172511, EBI-740727;
CC Q9BYR5; Q9BR84: ZNF559; NbExp=3; IntAct=EBI-10172511, EBI-746605;
CC Q9BYR5; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-10172511, EBI-745520;
CC Q9BYR5; A0A0S2Z5X4: ZNF688; NbExp=3; IntAct=EBI-10172511, EBI-16429014;
CC Q9BYR5; Q5BKY6; NbExp=3; IntAct=EBI-10172511, EBI-10243533;
CC -!- SIMILARITY: Belongs to the KRTAP type 4 family. {ECO:0000305}.
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DR EMBL; AJ406934; CAC27573.1; -; mRNA.
DR EMBL; AC006070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127252; AAI27253.1; -; mRNA.
DR CCDS; CCDS11384.1; -.
DR RefSeq; NP_149051.1; NM_033062.3.
DR AlphaFoldDB; Q9BYR5; -.
DR BioGRID; 124455; 126.
DR IntAct; Q9BYR5; 122.
DR BioMuta; KRTAP4-2; -.
DR DMDM; 296434557; -.
DR MassIVE; Q9BYR5; -.
DR PaxDb; Q9BYR5; -.
DR PeptideAtlas; Q9BYR5; -.
DR PRIDE; Q9BYR5; -.
DR ProteomicsDB; 79694; -.
DR DNASU; 85291; -.
DR Ensembl; ENST00000377726.3; ENSP00000366955.2; ENSG00000244537.3.
DR GeneID; 85291; -.
DR KEGG; hsa:85291; -.
DR MANE-Select; ENST00000377726.3; ENSP00000366955.2; NM_033062.4; NP_149051.2.
DR UCSC; uc002hwd.3; human.
DR CTD; 85291; -.
DR GeneCards; KRTAP4-2; -.
DR HGNC; HGNC:18900; KRTAP4-2.
DR HPA; ENSG00000244537; Tissue enriched (skin).
DR neXtProt; NX_Q9BYR5; -.
DR OpenTargets; ENSG00000244537; -.
DR PharmGKB; PA38749; -.
DR VEuPathDB; HostDB:ENSG00000244537; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000164350; -.
DR HOGENOM; CLU_113141_2_0_1; -.
DR InParanoid; Q9BYR5; -.
DR OMA; DYCCTDY; -.
DR OrthoDB; 1540957at2759; -.
DR PhylomeDB; Q9BYR5; -.
DR TreeFam; TF351356; -.
DR PathwayCommons; Q9BYR5; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q9BYR5; -.
DR BioGRID-ORCS; 85291; 509 hits in 988 CRISPR screens.
DR GenomeRNAi; 85291; -.
DR Pharos; Q9BYR5; Tdark.
DR PRO; PR:Q9BYR5; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q9BYR5; protein.
DR Bgee; ENSG00000244537; Expressed in tibialis anterior and 20 other tissues.
DR Genevisible; Q9BYR5; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 2.
DR Pfam; PF13885; Keratin_B2_2; 2.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..136
FT /note="Keratin-associated protein 4-2"
FT /id="PRO_0000185170"
FT REPEAT 5..9
FT /note="1"
FT REPEAT 20..24
FT /note="2"
FT REPEAT 25..29
FT /note="3"
FT REPEAT 30..34
FT /note="4"
FT REPEAT 35..39
FT /note="5"
FT REPEAT 40..44
FT /note="6"
FT REPEAT 45..49
FT /note="7"
FT REPEAT 50..54
FT /note="8"
FT REPEAT 55..59
FT /note="9"
FT REPEAT 60..64
FT /note="10"
FT REPEAT 65..69
FT /note="11"
FT REPEAT 70..74
FT /note="12"
FT REPEAT 75..79
FT /note="13"
FT REPEAT 80..84
FT /note="14"
FT REPEAT 90..94
FT /note="15"
FT REPEAT 95..99
FT /note="16"
FT REPEAT 100..104
FT /note="17"
FT REPEAT 110..114
FT /note="18"
FT REPEAT 120..124
FT /note="19"
FT REPEAT 125..129
FT /note="20"
FT REGION 5..129
FT /note="20 X 5 AA repeats OF C-C-[GRQVS]-[SPT]-[VSTQ]"
FT VARIANT 95
FT /note="Y -> C (in dbSNP:rs389784)"
FT /evidence="ECO:0000269|PubMed:11279113,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_060241"
SQ SEQUENCE 136 AA; 14462 MW; 51F82875EB25E02E CRC64;
MVNSCCGSVC SDQGCGLENC CRPSCCQTTC CRTTCCRPSC CVSSCCRPQC CQSVCCQPTC
CSPSCCQTTC CRTTCCRPSC CVSSCFRPQC CQSVYCQPTC CRPSCGQTTC CRTTCYRPSC
CVSTCCRPTC SSGSCC
