KRA52_MOUSE
ID KRA52_MOUSE Reviewed; 189 AA.
AC Q9D5Z7;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Keratin-associated protein 5-2 {ECO:0000250|UniProtKB:Q701N4};
GN Name=Krtap5-2 {ECO:0000312|MGI:MGI:1918873};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAB29552.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB29552.1};
RC TISSUE=Head {ECO:0000312|EMBL:BAB29552.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated protein (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the KRTAP type 5 family.
CC {ECO:0000250|UniProtKB:Q701N4}.
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DR EMBL; AK014785; BAB29552.1; -; mRNA.
DR RefSeq; NP_082120.3; NM_027844.4.
DR AlphaFoldDB; Q9D5Z7; -.
DR STRING; 10090.ENSMUSP00000140784; -.
DR PhosphoSitePlus; Q9D5Z7; -.
DR PaxDb; Q9D5Z7; -.
DR PRIDE; Q9D5Z7; -.
DR DNASU; 71623; -.
DR GeneID; 71623; -.
DR KEGG; mmu:71623; -.
DR CTD; 440021; -.
DR MGI; MGI:1918873; Krtap5-2.
DR BioGRID-ORCS; 71623; 7 hits in 45 CRISPR screens.
DR PRO; PR:Q9D5Z7; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9D5Z7; protein.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 2.
DR Pfam; PF13885; Keratin_B2_2; 1.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..189
FT /note="Keratin-associated protein 5-2"
FT /id="PRO_0000361658"
FT REPEAT 21..24
FT /note="1"
FT /evidence="ECO:0000255"
FT REPEAT 27..30
FT /note="2"
FT /evidence="ECO:0000255"
FT REPEAT 33..36
FT /note="3"
FT /evidence="ECO:0000255"
FT REPEAT 134..137
FT /note="4"
FT /evidence="ECO:0000255"
FT REPEAT 144..147
FT /note="5"
FT /evidence="ECO:0000255"
FT REPEAT 159..162
FT /note="6"
FT /evidence="ECO:0000255"
FT REPEAT 169..172
FT /note="7"
FT /evidence="ECO:0000255"
FT REPEAT 179..182
FT /note="8"
FT /evidence="ECO:0000255"
FT REGION 27..182
FT /note="8 X 4 AA repeats of C-C-X-P"
FT /evidence="ECO:0000255"
SQ SEQUENCE 189 AA; 17234 MW; B6A30BFB5E2AA31E CRC64;
MSCCGCSGGC GSSCGGCGSN CCKPVCCCKP VCCCVPACSC SSCGDCKGGC GSCGGCKGGC
GSCGGCKGGC GSCGGCKGGC GSCGGCGSCG GCKGGCSSCG GCGSCGGCKG GCGSCGGCGS
CGGCGSCGCC QSSCCKPCCC QSSCCKPCCC QSSCCQSSCC KPCCCQSSCC KPCCCQSSCC
APVCCQCKI
