ID   KRA53_MOUSE             Reviewed;         196 AA.
AC   Q9D226;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Keratin-associated protein 5-3 {ECO:0000250|UniProtKB:Q6L8H2};
GN   Name=Krtap5-3 {ECO:0000312|MGI:MGI:1924465};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:BAB32180.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:BAB32180.1};
RC   TISSUE=Neonatal skin {ECO:0000312|EMBL:BAB32180.1};
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated protein (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins. {ECO:0000305}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 5 family.
CC       {ECO:0000250|UniProtKB:Q6L8H2}.
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DR   EMBL; AK020699; BAB32180.1; -; mRNA.
DR   AlphaFoldDB; Q9D226; -.
DR   PaxDb; Q9D226; -.
DR   PRIDE; Q9D226; -.
DR   MGI; MGI:1924465; Krtap5-3.
DR   PRO; PR:Q9D226; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q9D226; protein.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..196
FT                   /note="Keratin-associated protein 5-3"
FT                   /id="PRO_0000361659"
FT   REPEAT          14..17
FT                   /note="1"
FT   REPEAT          20..23
FT                   /note="2"
FT   REGION          14..23
FT                   /note="2 X 4 AA repeats of C-C-X-P"
SQ   SEQUENCE   196 AA;  17777 MW;  2136738FD496D815 CRC64;
     MSCCGCCGGC GSSCCKPVCC CVPVCSCSSC GGCKGGCSSC GGCGSCGGCK GGCGSCGGCG
     SCGGCKGGCG SCGGCGSCGG CKGGCGSCGG CGSCGGCKGG CGSCGGCGSC GGCKGGCSSC
     GGCGSCGAAS PSCVSPAAAS PAVQALLLPV QLLQALLLPA QLLLVQLLLS LLLLHDCGSS
     CCPMSCSLPI YCQREI