KRA54_HUMAN
ID KRA54_HUMAN Reviewed; 288 AA.
AC Q6L8H1;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Keratin-associated protein 5-4;
DE AltName: Full=Keratin-associated protein 5.4;
DE AltName: Full=Ultrahigh sulfur keratin-associated protein 5.4;
GN Name=KRTAP5-4; Synonyms=KAP5.4, KRTAP5.4;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Hair root;
RX PubMed=15144888; DOI=10.1016/j.bbrc.2004.04.074;
RA Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J.,
RA Shimizu N.;
RT "Identification of two novel clusters of ultrahigh-sulfur keratin-
RT associated protein genes on human chromosome 11.";
RL Biochem. Biophys. Res. Commun. 318:655-664(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated protein (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q6L8H1; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11963072, EBI-10173507;
CC Q6L8H1; Q9UL15: BAG5; NbExp=3; IntAct=EBI-11963072, EBI-356517;
CC Q6L8H1; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-11963072, EBI-744545;
CC Q6L8H1; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-11963072, EBI-713677;
CC Q6L8H1; Q02930-3: CREB5; NbExp=3; IntAct=EBI-11963072, EBI-10192698;
CC Q6L8H1; Q49AN0: CRY2; NbExp=3; IntAct=EBI-11963072, EBI-2212355;
CC Q6L8H1; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11963072, EBI-3867333;
CC Q6L8H1; O76003: GLRX3; NbExp=3; IntAct=EBI-11963072, EBI-374781;
CC Q6L8H1; P49639: HOXA1; NbExp=8; IntAct=EBI-11963072, EBI-740785;
CC Q6L8H1; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-11963072, EBI-11959885;
CC Q6L8H1; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-11963072, EBI-11749135;
CC Q6L8H1; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11963072, EBI-10171774;
CC Q6L8H1; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-11963072, EBI-1052037;
CC Q6L8H1; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-11963072, EBI-11958178;
CC Q6L8H1; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-11963072, EBI-3958099;
CC Q6L8H1; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11963072, EBI-1044640;
CC Q6L8H1; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-11963072, EBI-1043191;
CC Q6L8H1; Q5T7P3: LCE1B; NbExp=5; IntAct=EBI-11963072, EBI-10245913;
CC Q6L8H1; Q5T751: LCE1C; NbExp=3; IntAct=EBI-11963072, EBI-12224199;
CC Q6L8H1; Q5T752: LCE1D; NbExp=3; IntAct=EBI-11963072, EBI-11741311;
CC Q6L8H1; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11963072, EBI-11955335;
CC Q6L8H1; Q5T754: LCE1F; NbExp=3; IntAct=EBI-11963072, EBI-11958008;
CC Q6L8H1; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11963072, EBI-11973993;
CC Q6L8H1; Q5TA76: LCE3A; NbExp=5; IntAct=EBI-11963072, EBI-9394625;
CC Q6L8H1; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-11963072, EBI-11974495;
CC Q6L8H1; Q5T5A8: LCE3C; NbExp=5; IntAct=EBI-11963072, EBI-10245291;
CC Q6L8H1; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-11963072, EBI-10246358;
CC Q6L8H1; Q5TCM9: LCE5A; NbExp=4; IntAct=EBI-11963072, EBI-11955689;
CC Q6L8H1; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-11963072, EBI-16439278;
CC Q6L8H1; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11963072, EBI-22310682;
CC Q6L8H1; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-11963072, EBI-1210753;
CC Q6L8H1; P32242: OTX1; NbExp=3; IntAct=EBI-11963072, EBI-740446;
CC Q6L8H1; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-11963072, EBI-742388;
CC Q6L8H1; Q12837: POU4F2; NbExp=3; IntAct=EBI-11963072, EBI-17236143;
CC Q6L8H1; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-11963072, EBI-3918154;
CC Q6L8H1; P49901: SMCP; NbExp=3; IntAct=EBI-11963072, EBI-750494;
CC Q6L8H1; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-11963072, EBI-10180829;
CC -!- TISSUE SPECIFICITY: Restricted to hair root, not detected in any other
CC tissues. {ECO:0000269|PubMed:15144888}.
CC -!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}.
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DR EMBL; AB126073; BAD20200.1; -; mRNA.
DR RefSeq; NP_001012727.1; NM_001012709.1.
DR AlphaFoldDB; Q6L8H1; -.
DR BioGRID; 132268; 36.
DR IntAct; Q6L8H1; 37.
DR iPTMnet; Q6L8H1; -.
DR PhosphoSitePlus; Q6L8H1; -.
DR BioMuta; KRTAP5-4; -.
DR PeptideAtlas; Q6L8H1; -.
DR PRIDE; Q6L8H1; -.
DR DNASU; 387267; -.
DR Ensembl; ENST00000630519.1; ENSP00000486225.1; ENSG00000278620.3.
DR GeneID; 387267; -.
DR KEGG; hsa:387267; -.
DR UCSC; uc031ypm.1; human.
DR CTD; 387267; -.
DR DisGeNET; 387267; -.
DR GeneCards; KRTAP5-4; -.
DR HGNC; HGNC:23599; KRTAP5-4.
DR neXtProt; NX_Q6L8H1; -.
DR PharmGKB; PA134916197; -.
DR PathwayCommons; Q6L8H1; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q6L8H1; -.
DR BioGRID-ORCS; 387267; 5 hits in 141 CRISPR screens.
DR GenomeRNAi; 387267; -.
DR Pharos; Q6L8H1; Tdark.
DR PRO; PR:Q6L8H1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6L8H1; protein.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 3.
DR Pfam; PF13885; Keratin_B2_2; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..288
FT /note="Keratin-associated protein 5-4"
FT /id="PRO_0000184102"
FT REPEAT 49..52
FT /note="1"
FT REPEAT 55..58
FT /note="2"
FT REPEAT 61..64
FT /note="3"
FT REPEAT 201..204
FT /note="4"
FT REPEAT 220..223
FT /note="5"
FT REPEAT 239..242
FT /note="6"
FT REPEAT 249..252
FT /note="7"
FT REPEAT 268..271
FT /note="8"
FT REPEAT 278..281
FT /note="9"
FT REGION 49..281
FT /note="9 X 4 AA repeats of C-C-X-P"
SQ SEQUENCE 288 AA; 25249 MW; 8C2F4E3CA65B4A1D CRC64;
MGCCGCSGGC GSGCGGCGSG CGGCGSGCGG CGSGCGGCGS GCGGCGSSCC VPICCCKPVC
CCVPACSCSS CGSCGGSKGG YGSCGGSKGG CVSCGGSKGG CGSCGGSKGG CGSCGGSKGG
CGSCGGSKGG CVSCGGSKGG CGSCGGSKGG CVSCGGSKGG CGSCGGSKGG CGSCGGSKGG
CGSCGGSKGG CGSCGCSQCS CCKPCCCSSG CGSSCCQSSC CKPCCSSSGC GSSCCQSSCC
KPYCCQSSCC KPCCSSSGCG SSCCQSSCCN PCCSQSSCCV PVCCQCKI
