KRA54_MOUSE
ID KRA54_MOUSE Reviewed; 223 AA.
AC Q62220;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Keratin-associated protein 5-4 {ECO:0000250|UniProtKB:Q6L8H1};
DE AltName: Full=Ultra high sulfur serine protein 2;
DE Short=UHS-Ser-2;
GN Name=Krtap5-4 {ECO:0000312|MGI:MGI:1354758};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAA40107.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ {ECO:0000312|EMBL:AAA40107.1};
RX PubMed=2250030; DOI=10.1016/s0021-9258(17)45371-3;
RA Wood L., Mills M., Hatzenbuhler N., Vogeli G.;
RT "Serine-rich ultra high sulfur protein gene expression in murine hair and
RT skin during the hair cycle.";
RL J. Biol. Chem. 265:21375-21380(1990).
RN [2]
RP ERRATUM OF PUBMED:2250030.
RX PubMed=1840598; DOI=10.1016/s0021-9258(19)67899-3;
RA Wood L., Mills M., Hatzenbuhler N., Vogeli G.;
RL J. Biol. Chem. 266:4024-4024(1991).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated protein (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed during the active phases of the hair
CC cycle in the medulla and the inner root sheath of the forming hair.
CC Also expressed in the upper layers of the epidermis of skin.
CC {ECO:0000269|PubMed:2250030}.
CC -!- SIMILARITY: Belongs to the KRTAP type 5 family.
CC {ECO:0000250|UniProtKB:Q6L8H1}.
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DR EMBL; M37760; AAA40107.1; -; Genomic_DNA.
DR CCDS; CCDS22027.1; -.
DR PIR; A38660; B38346.
DR RefSeq; NP_056624.1; NM_015809.2.
DR AlphaFoldDB; Q62220; -.
DR STRING; 10090.ENSMUSP00000059461; -.
DR PaxDb; Q62220; -.
DR PRIDE; Q62220; -.
DR DNASU; 50775; -.
DR Ensembl; ENSMUST00000061403; ENSMUSP00000059461; ENSMUSG00000045236.
DR GeneID; 50775; -.
DR KEGG; mmu:50775; -.
DR UCSC; uc009kms.1; mouse.
DR CTD; 387267; -.
DR MGI; MGI:1354758; Krtap5-4.
DR VEuPathDB; HostDB:ENSMUSG00000045236; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00940000164129; -.
DR HOGENOM; CLU_097966_0_0_1; -.
DR OMA; ACTCTAN; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR BioGRID-ORCS; 50775; 7 hits in 50 CRISPR screens.
DR PRO; PR:Q62220; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q62220; protein.
DR Bgee; ENSMUSG00000045236; Expressed in lip and 6 other tissues.
DR Genevisible; Q62220; MM.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 5.
DR Pfam; PF13885; Keratin_B2_2; 2.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..223
FT /note="Keratin-associated protein 5-4"
FT /id="PRO_0000361660"
FT REPEAT 21..24
FT /note="1"
FT /evidence="ECO:0000255"
FT REPEAT 27..30
FT /note="2"
FT /evidence="ECO:0000255"
FT REPEAT 79..82
FT /note="3"
FT /evidence="ECO:0000255"
FT REPEAT 89..92
FT /note="4"
FT /evidence="ECO:0000255"
FT REPEAT 107..110
FT /note="5"
FT /evidence="ECO:0000255"
FT REPEAT 117..120
FT /note="6"
FT /evidence="ECO:0000255"
FT REPEAT 135..138
FT /note="7"
FT /evidence="ECO:0000255"
FT REPEAT 145..148
FT /note="8"
FT /evidence="ECO:0000255"
FT REPEAT 155..158
FT /note="9"
FT /evidence="ECO:0000255"
FT REPEAT 173..176
FT /note="10"
FT /evidence="ECO:0000255"
FT REPEAT 183..186
FT /note="11"
FT /evidence="ECO:0000255"
FT REPEAT 193..196
FT /note="12"
FT /evidence="ECO:0000255"
FT REPEAT 203..206
FT /note="13"
FT /evidence="ECO:0000255"
FT REPEAT 213..216
FT /note="14"
FT /evidence="ECO:0000255"
FT REGION 21..216
FT /note="14 X 4 AA repeats of C-C-X-P"
FT /evidence="ECO:0000255"
SQ SEQUENCE 223 AA; 21442 MW; C654BDB9FD08C59A CRC64;
MTCCGCSGGC GSSCGGCGSS CCKPVCCCVP VCSCSSCGGC KGGCGSCGGC KGGCGSCGGC
KGGCGSCGGC KGGCCQSSCC KPCCCQSSCC KPCCSSGCGS SCCQSSCCKP CCCQSSCCKP
CCSSGCGSSC CQSSCCKPCC CQSSCCKPCC CQSSCCKPCC SSGCGSSCCQ SSCCKPCCCQ
SSCCKPCCCQ SSCCKPCCCQ SSCCKPCCCQ SSCCAPVCCQ CKI
