ID   KRA55_MOUSE             Reviewed;         241 AA.
AC   Q2TA51;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-JAN-2006, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Keratin-associated protein 5-5;
GN   Name=Krtap5-5 {ECO:0000312|MGI:MGI:2149673};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:AAI11114.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated protein (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins. {ECO:0000305}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 5 family.
CC       {ECO:0000250|UniProtKB:Q701N2}.
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DR   EMBL; BC111113; AAI11114.1; -; mRNA.
DR   CCDS; CCDS22026.1; -.
DR   RefSeq; NP_001032911.1; NM_001037822.1.
DR   AlphaFoldDB; Q2TA51; -.
DR   STRING; 10090.ENSMUSP00000095555; -.
DR   PaxDb; Q2TA51; -.
DR   PRIDE; Q2TA51; -.
DR   Ensembl; ENSMUST00000097942; ENSMUSP00000095555; ENSMUSG00000073785.
DR   GeneID; 114666; -.
DR   KEGG; mmu:114666; -.
DR   UCSC; uc009kmq.1; mouse.
DR   CTD; 439915; -.
DR   MGI; MGI:2149673; Krtap5-5.
DR   VEuPathDB; HostDB:ENSMUSG00000073785; -.
DR   eggNOG; KOG4726; Eukaryota.
DR   GeneTree; ENSGT00940000164129; -.
DR   HOGENOM; CLU_097966_0_0_1; -.
DR   OMA; CCKDAPC; -.
DR   Reactome; R-MMU-6805567; Keratinization.
DR   BioGRID-ORCS; 114666; 3 hits in 48 CRISPR screens.
DR   PRO; PR:Q2TA51; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q2TA51; protein.
DR   Bgee; ENSMUSG00000073785; Expressed in lip and 8 other tissues.
DR   Genevisible; Q2TA51; MM.
DR   GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IMP:MGI.
DR   InterPro; IPR002494; KAP.
DR   PANTHER; PTHR23262; PTHR23262; 4.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..241
FT                   /note="Keratin-associated protein 5-5"
FT                   /id="PRO_0000361661"
FT   REPEAT          35..38
FT                   /note="1"
FT                   /evidence="ECO:0000255"
FT   REPEAT          41..44
FT                   /note="2"
FT                   /evidence="ECO:0000255"
FT   REPEAT          47..50
FT                   /note="3"
FT                   /evidence="ECO:0000255"
FT   REPEAT          105..108
FT                   /note="4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          115..118
FT                   /note="5"
FT                   /evidence="ECO:0000255"
FT   REPEAT          133..136
FT                   /note="6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          143..146
FT                   /note="7"
FT                   /evidence="ECO:0000255"
FT   REPEAT          161..164
FT                   /note="8"
FT                   /evidence="ECO:0000255"
FT   REPEAT          171..174
FT                   /note="9"
FT                   /evidence="ECO:0000255"
FT   REPEAT          181..184
FT                   /note="10"
FT                   /evidence="ECO:0000255"
FT   REPEAT          191..194
FT                   /note="11"
FT                   /evidence="ECO:0000255"
FT   REPEAT          201..204
FT                   /note="12"
FT                   /evidence="ECO:0000255"
FT   REPEAT          211..214
FT                   /note="13"
FT                   /evidence="ECO:0000255"
FT   REPEAT          221..224
FT                   /note="14"
FT                   /evidence="ECO:0000255"
FT   REPEAT          231..234
FT                   /note="15"
FT                   /evidence="ECO:0000255"
FT   REGION          35..234
FT                   /note="15 X 4 AA repeats of C-C-X-P"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   241 AA;  23063 MW;  41A73039A2C9E91E CRC64;
     MTCCGCSGGC GSSCGGCGCS GGCGSSCGGC GSSCCCKPVC CCKPVCCCVP ACSCSSCGGC
     KGGCGSCGGC KGSCGSCGGC KGGCGSCGGC GSCGGCKPSC CQSSCCKPCC CQSSCCKPCC
     SSGCGSSCCQ SSCCKPCCCQ SSCCKPCCSS GCGSSCCQSS CCKPCCCQSS CCKPCCCQSS
     CCKPCCCQSS CCKPCCCQSS CCKPCCCQSS CCKPCCCQSS CCKPCCCQSS CCAPVCCQCK
     I