KRA56_HUMAN
ID KRA56_HUMAN Reviewed; 129 AA.
AC Q6L8G9; A1L452;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Keratin-associated protein 5-6;
DE AltName: Full=Keratin-associated protein 5.6;
DE AltName: Full=Ultrahigh sulfur keratin-associated protein 5.6;
GN Name=KRTAP5-6; Synonyms=KAP5.6, KRTAP5.6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Hair root;
RX PubMed=15144888; DOI=10.1016/j.bbrc.2004.04.074;
RA Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J.,
RA Shimizu N.;
RT "Identification of two novel clusters of ultrahigh-sulfur keratin-
RT associated protein genes on human chromosome 11.";
RL Biochem. Biophys. Res. Commun. 318:655-664(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated protein (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q6L8G9; O43184-4: ADAM12; NbExp=3; IntAct=EBI-10250562, EBI-12006944;
CC Q6L8G9; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-10250562, EBI-10173507;
CC Q6L8G9; Q6P5X5: C22orf39; NbExp=3; IntAct=EBI-10250562, EBI-7317823;
CC Q6L8G9; Q8NEC5: CATSPER1; NbExp=6; IntAct=EBI-10250562, EBI-744545;
CC Q6L8G9; P48745: CCN3; NbExp=3; IntAct=EBI-10250562, EBI-3904822;
CC Q6L8G9; P27658: COL8A1; NbExp=3; IntAct=EBI-10250562, EBI-747133;
CC Q6L8G9; Q9UGL9: CRCT1; NbExp=6; IntAct=EBI-10250562, EBI-713677;
CC Q6L8G9; Q02930-3: CREB5; NbExp=6; IntAct=EBI-10250562, EBI-10192698;
CC Q6L8G9; A8MQ03: CYSRT1; NbExp=6; IntAct=EBI-10250562, EBI-3867333;
CC Q6L8G9; Q96D03: DDIT4L; NbExp=3; IntAct=EBI-10250562, EBI-742054;
CC Q6L8G9; O76003: GLRX3; NbExp=7; IntAct=EBI-10250562, EBI-374781;
CC Q6L8G9; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-10250562, EBI-11978177;
CC Q6L8G9; P49639: HOXA1; NbExp=9; IntAct=EBI-10250562, EBI-740785;
CC Q6L8G9; Q0VD86: INCA1; NbExp=3; IntAct=EBI-10250562, EBI-6509505;
CC Q6L8G9; Q15323: KRT31; NbExp=3; IntAct=EBI-10250562, EBI-948001;
CC Q6L8G9; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-10250562, EBI-11959885;
CC Q6L8G9; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-10250562, EBI-11749135;
CC Q6L8G9; Q9BYS1: KRTAP1-5; NbExp=3; IntAct=EBI-10250562, EBI-11741292;
CC Q6L8G9; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-10250562, EBI-10172150;
CC Q6L8G9; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-10250562, EBI-10172290;
CC Q6L8G9; P60410: KRTAP10-8; NbExp=8; IntAct=EBI-10250562, EBI-10171774;
CC Q6L8G9; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10250562, EBI-10172052;
CC Q6L8G9; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-10250562, EBI-1052037;
CC Q6L8G9; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-10250562, EBI-10210845;
CC Q6L8G9; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-10250562, EBI-11953334;
CC Q6L8G9; Q3SY46: KRTAP13-3; NbExp=3; IntAct=EBI-10250562, EBI-10241252;
CC Q6L8G9; Q9BYP8: KRTAP17-1; NbExp=5; IntAct=EBI-10250562, EBI-11988175;
CC Q6L8G9; Q6PEX3: KRTAP26-1; NbExp=6; IntAct=EBI-10250562, EBI-3957672;
CC Q6L8G9; Q9BYR6: KRTAP3-3; NbExp=3; IntAct=EBI-10250562, EBI-3957694;
CC Q6L8G9; A0A087WY89: KRTAP4-1; NbExp=3; IntAct=EBI-10250562, EBI-11957260;
CC Q6L8G9; Q9BYQ6: KRTAP4-11; NbExp=3; IntAct=EBI-10250562, EBI-10302392;
CC Q6L8G9; Q9BQ66: KRTAP4-12; NbExp=6; IntAct=EBI-10250562, EBI-739863;
CC Q6L8G9; Q9BYR5: KRTAP4-2; NbExp=8; IntAct=EBI-10250562, EBI-10172511;
CC Q6L8G9; Q6L8H4: KRTAP5-1; NbExp=3; IntAct=EBI-10250562, EBI-12074540;
CC Q6L8G9; Q6L8G8: KRTAP5-7; NbExp=4; IntAct=EBI-10250562, EBI-11987425;
CC Q6L8G9; P26371: KRTAP5-9; NbExp=9; IntAct=EBI-10250562, EBI-3958099;
CC Q6L8G9; Q9BYQ4: KRTAP9-2; NbExp=8; IntAct=EBI-10250562, EBI-1044640;
CC Q6L8G9; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-10250562, EBI-1043191;
CC Q6L8G9; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-10250562, EBI-10185730;
CC Q6L8G9; Q9BYQ0: KRTAP9-8; NbExp=4; IntAct=EBI-10250562, EBI-11958364;
CC Q6L8G9; P52954: LBX1; NbExp=3; IntAct=EBI-10250562, EBI-20141748;
CC Q6L8G9; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-10250562, EBI-11962058;
CC Q6L8G9; Q5T7P3: LCE1B; NbExp=5; IntAct=EBI-10250562, EBI-10245913;
CC Q6L8G9; Q5T751: LCE1C; NbExp=3; IntAct=EBI-10250562, EBI-12224199;
CC Q6L8G9; Q5T752: LCE1D; NbExp=6; IntAct=EBI-10250562, EBI-11741311;
CC Q6L8G9; Q5T753: LCE1E; NbExp=3; IntAct=EBI-10250562, EBI-11955335;
CC Q6L8G9; Q5T754: LCE1F; NbExp=3; IntAct=EBI-10250562, EBI-11958008;
CC Q6L8G9; Q5TA79: LCE2A; NbExp=3; IntAct=EBI-10250562, EBI-10246607;
CC Q6L8G9; Q5TA81: LCE2C; NbExp=6; IntAct=EBI-10250562, EBI-11973993;
CC Q6L8G9; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-10250562, EBI-10246750;
CC Q6L8G9; Q5TA76: LCE3A; NbExp=6; IntAct=EBI-10250562, EBI-9394625;
CC Q6L8G9; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-10250562, EBI-11974495;
CC Q6L8G9; Q5T5A8: LCE3C; NbExp=3; IntAct=EBI-10250562, EBI-10245291;
CC Q6L8G9; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-10250562, EBI-6658837;
CC Q6L8G9; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-10250562, EBI-10245456;
CC Q6L8G9; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-10250562, EBI-10246358;
CC Q6L8G9; Q5TCM9: LCE5A; NbExp=5; IntAct=EBI-10250562, EBI-11955689;
CC Q6L8G9; Q5T871: LELP1; NbExp=3; IntAct=EBI-10250562, EBI-18115868;
CC Q6L8G9; Q96FE5: LINGO1; NbExp=3; IntAct=EBI-10250562, EBI-719955;
CC Q6L8G9; Q8IXW0: LMNTD2; NbExp=3; IntAct=EBI-10250562, EBI-12028858;
CC Q6L8G9; O60336: MAPKBP1; NbExp=3; IntAct=EBI-10250562, EBI-947402;
CC Q6L8G9; P50222: MEOX2; NbExp=3; IntAct=EBI-10250562, EBI-748397;
CC Q6L8G9; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-10250562, EBI-16439278;
CC Q6L8G9; Q86VE0: MYPOP; NbExp=3; IntAct=EBI-10250562, EBI-2858213;
CC Q6L8G9; Q9UBE8: NLK; NbExp=3; IntAct=EBI-10250562, EBI-366978;
CC Q6L8G9; Q7Z3S9: NOTCH2NLA; NbExp=4; IntAct=EBI-10250562, EBI-945833;
CC Q6L8G9; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-10250562, EBI-22310682;
CC Q6L8G9; A8MTQ0: NOTO; NbExp=3; IntAct=EBI-10250562, EBI-17490746;
CC Q6L8G9; Q6NSM0: NR1D2; NbExp=3; IntAct=EBI-10250562, EBI-10250949;
CC Q6L8G9; Q92570: NR4A3; NbExp=3; IntAct=EBI-10250562, EBI-13644623;
CC Q6L8G9; Q7Z417: NUFIP2; NbExp=6; IntAct=EBI-10250562, EBI-1210753;
CC Q6L8G9; P32242: OTX1; NbExp=6; IntAct=EBI-10250562, EBI-740446;
CC Q6L8G9; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-10250562, EBI-12813389;
CC Q6L8G9; O15162: PLSCR1; NbExp=3; IntAct=EBI-10250562, EBI-740019;
CC Q6L8G9; Q12837: POU4F2; NbExp=3; IntAct=EBI-10250562, EBI-17236143;
CC Q6L8G9; Q9UGC6: RGS17; NbExp=3; IntAct=EBI-10250562, EBI-3918154;
CC Q6L8G9; P49795: RGS19; NbExp=3; IntAct=EBI-10250562, EBI-874907;
CC Q6L8G9; O76081-6: RGS20; NbExp=6; IntAct=EBI-10250562, EBI-10178530;
CC Q6L8G9; P49901: SMCP; NbExp=8; IntAct=EBI-10250562, EBI-750494;
CC Q6L8G9; O43597: SPRY2; NbExp=3; IntAct=EBI-10250562, EBI-742487;
CC Q6L8G9; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-10250562, EBI-11957216;
CC Q6L8G9; P25490: YY1; NbExp=3; IntAct=EBI-10250562, EBI-765538;
CC -!- TISSUE SPECIFICITY: Expressed in hair root and not in skin. Expressed
CC also in liver and skeletal muscle. {ECO:0000269|PubMed:15144888}.
CC -!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}.
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DR EMBL; AB126075; BAD20202.1; -; mRNA.
DR EMBL; BC130399; AAI30400.1; -; mRNA.
DR EMBL; BC133035; AAI33036.1; -; mRNA.
DR CCDS; CCDS31332.1; -.
DR RefSeq; NP_001012416.1; NM_001012416.1.
DR AlphaFoldDB; Q6L8G9; -.
DR BioGRID; 136221; 79.
DR IntAct; Q6L8G9; 82.
DR STRING; 9606.ENSP00000371595; -.
DR iPTMnet; Q6L8G9; -.
DR PhosphoSitePlus; Q6L8G9; -.
DR BioMuta; KRTAP5-6; -.
DR PaxDb; Q6L8G9; -.
DR PeptideAtlas; Q6L8G9; -.
DR PRIDE; Q6L8G9; -.
DR DNASU; 440023; -.
DR Ensembl; ENST00000382160.1; ENSP00000371595.1; ENSG00000205864.1.
DR Ensembl; ENST00000611731.1; ENSP00000479098.1; ENSG00000277389.1.
DR GeneID; 440023; -.
DR KEGG; hsa:440023; -.
DR MANE-Select; ENST00000382160.1; ENSP00000371595.1; NM_001012416.1; NP_001012416.1.
DR UCSC; uc001lua.3; human.
DR CTD; 440023; -.
DR GeneCards; KRTAP5-6; -.
DR HGNC; HGNC:23600; KRTAP5-6.
DR HPA; ENSG00000205864; Tissue enhanced (liver).
DR neXtProt; NX_Q6L8G9; -.
DR OpenTargets; ENSG00000205864; -.
DR PharmGKB; PA134922071; -.
DR VEuPathDB; HostDB:ENSG00000205864; -.
DR eggNOG; ENOG502TEXH; Eukaryota.
DR GeneTree; ENSGT00940000164776; -.
DR HOGENOM; CLU_097966_1_0_1; -.
DR OMA; CKSSHCQ; -.
DR PathwayCommons; Q6L8G9; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q6L8G9; -.
DR BioGRID-ORCS; 440023; 318 hits in 990 CRISPR screens.
DR GenomeRNAi; 440023; -.
DR Pharos; Q6L8G9; Tdark.
DR PRO; PR:Q6L8G9; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6L8G9; protein.
DR Bgee; ENSG00000205864; Expressed in right lobe of liver and 19 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..129
FT /note="Keratin-associated protein 5-6"
FT /id="PRO_0000184104"
FT REPEAT 28..31
FT /note="1"
FT REPEAT 34..37
FT /note="2"
FT REPEAT 40..43
FT /note="3"
FT REPEAT 90..93
FT /note="4"
FT REPEAT 109..112
FT /note="5"
FT REPEAT 119..122
FT /note="6"
FT REGION 28..112
FT /note="6 X 4 AA repeats of C-C-X-P"
FT VARIANT 6
FT /note="C -> F (in dbSNP:rs58645950)"
FT /id="VAR_062155"
SQ SEQUENCE 129 AA; 11784 MW; 3C19C560119E2C3F CRC64;
MGCCGCSGGC GSGCGGCGSG CGGCGSSCCV PICCCKPVCC CVPACSCTSC GSCGGSKGCC
GSCGGSKGGC GSCGGSKGGC GSCGCSQCSC CKPCYCSSGC GSSCCQSSCC KPCCSQASCC
VPICCQCKI
