KRA57_HUMAN
ID KRA57_HUMAN Reviewed; 165 AA.
AC Q6L8G8; B2RNM3; Q701N5;
DT 21-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Keratin-associated protein 5-7;
DE AltName: Full=Keratin-associated protein 5-3;
DE AltName: Full=Keratin-associated protein 5.3;
DE AltName: Full=Keratin-associated protein 5.7;
DE AltName: Full=Ultrahigh sulfur keratin-associated protein 5.7;
GN Name=KRTAP5-7; Synonyms=KAP5-7, KAP5.3, KRTAP5.3, KRTAP5.7;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Hair root;
RX PubMed=15144888; DOI=10.1016/j.bbrc.2004.04.074;
RA Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J.,
RA Shimizu N.;
RT "Identification of two novel clusters of ultrahigh-sulfur keratin-
RT associated protein genes on human chromosome 11.";
RL Biochem. Biophys. Res. Commun. 318:655-664(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 128-165.
RC TISSUE=Scalp;
RA Rogers M.A., Langbein L., Winter H., Praetzel S., Schweizer J.;
RT "Characterization of two domains of keratin associated protein (KAP) family
RT members on human chromosome 11.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated protein (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC Q6L8G8; P82987: ADAMTSL3; NbExp=3; IntAct=EBI-11987425, EBI-10221726;
CC Q6L8G8; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-11987425, EBI-10173507;
CC Q6L8G8; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-11987425, EBI-11530605;
CC Q6L8G8; Q6UXG3: CD300LG; NbExp=3; IntAct=EBI-11987425, EBI-10254587;
CC Q6L8G8; P27658: COL8A1; NbExp=3; IntAct=EBI-11987425, EBI-747133;
CC Q6L8G8; Q9UGL9: CRCT1; NbExp=3; IntAct=EBI-11987425, EBI-713677;
CC Q6L8G8; Q02930-3: CREB5; NbExp=3; IntAct=EBI-11987425, EBI-10192698;
CC Q6L8G8; Q49AN0: CRY2; NbExp=3; IntAct=EBI-11987425, EBI-2212355;
CC Q6L8G8; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11987425, EBI-3867333;
CC Q6L8G8; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-11987425, EBI-9679045;
CC Q6L8G8; Q92608: DOCK2; NbExp=3; IntAct=EBI-11987425, EBI-448771;
CC Q6L8G8; Q3B820: FAM161A; NbExp=3; IntAct=EBI-11987425, EBI-719941;
CC Q6L8G8; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-11987425, EBI-11978177;
CC Q6L8G8; Q03014: HHEX; NbExp=3; IntAct=EBI-11987425, EBI-747421;
CC Q6L8G8; P17482: HOXB9; NbExp=3; IntAct=EBI-11987425, EBI-745290;
CC Q6L8G8; P24592: IGFBP6; NbExp=3; IntAct=EBI-11987425, EBI-947015;
CC Q6L8G8; Q969P0: IGSF8; NbExp=3; IntAct=EBI-11987425, EBI-8293590;
CC Q6L8G8; P31785: IL2RG; NbExp=3; IntAct=EBI-11987425, EBI-80475;
CC Q6L8G8; P18084: ITGB5; NbExp=3; IntAct=EBI-11987425, EBI-1223434;
CC Q6L8G8; Q5T749: KPRP; NbExp=3; IntAct=EBI-11987425, EBI-10981970;
CC Q6L8G8; P60014: KRTAP10-10; NbExp=3; IntAct=EBI-11987425, EBI-11955579;
CC Q6L8G8; Q9BYR5: KRTAP4-2; NbExp=4; IntAct=EBI-11987425, EBI-10172511;
CC Q6L8G8; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-11987425, EBI-11958132;
CC Q6L8G8; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-11987425, EBI-11993296;
CC Q6L8G8; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-11987425, EBI-11958178;
CC Q6L8G8; Q6L8G9: KRTAP5-6; NbExp=4; IntAct=EBI-11987425, EBI-10250562;
CC Q6L8G8; Q9BYQ4: KRTAP9-2; NbExp=3; IntAct=EBI-11987425, EBI-1044640;
CC Q6L8G8; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-11987425, EBI-11962058;
CC Q6L8G8; Q5T7P3: LCE1B; NbExp=3; IntAct=EBI-11987425, EBI-10245913;
CC Q6L8G8; Q5T753: LCE1E; NbExp=3; IntAct=EBI-11987425, EBI-11955335;
CC Q6L8G8; O14633: LCE2B; NbExp=3; IntAct=EBI-11987425, EBI-11478468;
CC Q6L8G8; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11987425, EBI-11973993;
CC Q6L8G8; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-11987425, EBI-10246750;
CC Q6L8G8; Q5TA76: LCE3A; NbExp=3; IntAct=EBI-11987425, EBI-9394625;
CC Q6L8G8; Q5TA77: LCE3B; NbExp=3; IntAct=EBI-11987425, EBI-11974495;
CC Q6L8G8; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-11987425, EBI-6658837;
CC Q6L8G8; Q5T5B0: LCE3E; NbExp=3; IntAct=EBI-11987425, EBI-10245456;
CC Q6L8G8; Q5TA78: LCE4A; NbExp=3; IntAct=EBI-11987425, EBI-10246358;
CC Q6L8G8; Q8N5G2: MACO1; NbExp=3; IntAct=EBI-11987425, EBI-2683507;
CC Q6L8G8; O60336: MAPKBP1; NbExp=3; IntAct=EBI-11987425, EBI-947402;
CC Q6L8G8; Q9NV56: MRGBP; NbExp=3; IntAct=EBI-11987425, EBI-399076;
CC Q6L8G8; P50539-3: MXI1; NbExp=3; IntAct=EBI-11987425, EBI-10211940;
CC Q6L8G8; P52179-2: MYOM1; NbExp=3; IntAct=EBI-11987425, EBI-12010196;
CC Q6L8G8; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-11987425, EBI-14084211;
CC Q6L8G8; Q8WUK0: PTPMT1; NbExp=3; IntAct=EBI-11987425, EBI-7199479;
CC Q6L8G8; O60896: RAMP3; NbExp=3; IntAct=EBI-11987425, EBI-720447;
CC Q6L8G8; Q96NU1: SAMD11; NbExp=3; IntAct=EBI-11987425, EBI-14067109;
CC Q6L8G8; Q14162: SCARF1; NbExp=3; IntAct=EBI-11987425, EBI-12056025;
CC Q6L8G8; A0A0S2Z4U3: SDC3; NbExp=3; IntAct=EBI-11987425, EBI-10204280;
CC Q6L8G8; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-11987425, EBI-11955083;
CC Q6L8G8; Q92504: SLC39A7; NbExp=3; IntAct=EBI-11987425, EBI-1051105;
CC Q6L8G8; A0A024R4B0: SPATA3; NbExp=3; IntAct=EBI-11987425, EBI-14123856;
CC Q6L8G8; Q8IWZ5: TRIM42; NbExp=3; IntAct=EBI-11987425, EBI-5235829;
CC Q6L8G8; Q9UBK9: UXT; NbExp=3; IntAct=EBI-11987425, EBI-357355;
CC Q6L8G8; O96014: WNT11; NbExp=3; IntAct=EBI-11987425, EBI-8058160;
CC Q6L8G8; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-11987425, EBI-373456;
CC Q6L8G8; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-11987425, EBI-726439;
CC Q6L8G8; Q96JC4: ZNF479; NbExp=3; IntAct=EBI-11987425, EBI-10820574;
CC Q6L8G8; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-11987425, EBI-6427977;
CC Q6L8G8; Q6PF04: ZNF613; NbExp=3; IntAct=EBI-11987425, EBI-12062855;
CC -!- TISSUE SPECIFICITY: Expressed in hair root but not in skin.
CC {ECO:0000269|PubMed:15144888}.
CC -!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}.
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DR EMBL; AB126076; BAD20203.1; -; mRNA.
DR EMBL; BC136967; AAI36968.1; -; mRNA.
DR EMBL; BC136968; AAI36969.1; -; mRNA.
DR EMBL; AJ628243; CAF31636.1; -; mRNA.
DR CCDS; CCDS41682.1; -.
DR RefSeq; NP_001012521.1; NM_001012503.1.
DR AlphaFoldDB; Q6L8G8; -.
DR BioGRID; 136247; 61.
DR IntAct; Q6L8G8; 60.
DR STRING; 9606.ENSP00000417330; -.
DR iPTMnet; Q6L8G8; -.
DR PhosphoSitePlus; Q6L8G8; -.
DR BioMuta; KRTAP5-7; -.
DR PaxDb; Q6L8G8; -.
DR PeptideAtlas; Q6L8G8; -.
DR PRIDE; Q6L8G8; -.
DR DNASU; 440050; -.
DR Ensembl; ENST00000398536.6; ENSP00000417330.2; ENSG00000244411.4.
DR GeneID; 440050; -.
DR KEGG; hsa:440050; -.
DR MANE-Select; ENST00000398536.6; ENSP00000417330.2; NM_001012503.2; NP_001012521.1.
DR UCSC; uc001oqq.2; human.
DR CTD; 440050; -.
DR GeneCards; KRTAP5-7; -.
DR HGNC; HGNC:23602; KRTAP5-7.
DR HPA; ENSG00000244411; Tissue enhanced (skin, testis).
DR neXtProt; NX_Q6L8G8; -.
DR OpenTargets; ENSG00000244411; -.
DR PharmGKB; PA134880610; -.
DR VEuPathDB; HostDB:ENSG00000244411; -.
DR eggNOG; ENOG502TEPC; Eukaryota.
DR GeneTree; ENSGT00990000205266; -.
DR HOGENOM; CLU_097966_1_0_1; -.
DR OMA; KGSSACC; -.
DR PathwayCommons; Q6L8G8; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q6L8G8; -.
DR BioGRID-ORCS; 440050; 380 hits in 987 CRISPR screens.
DR GenomeRNAi; 440050; -.
DR Pharos; Q6L8G8; Tdark.
DR PRO; PR:Q6L8G8; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q6L8G8; protein.
DR Bgee; ENSG00000244411; Expressed in substantia nigra and 38 other tissues.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 3.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..165
FT /note="Keratin-associated protein 5-7"
FT /id="PRO_0000184105"
FT REPEAT 35..38
FT /note="1"
FT REPEAT 41..44
FT /note="2"
FT REPEAT 47..50
FT /note="3"
FT REPEAT 116..119
FT /note="4"
FT REPEAT 126..129
FT /note="5"
FT REPEAT 145..148
FT /note="6"
FT REPEAT 155..158
FT /note="7"
FT REGION 35..158
FT /note="7 X 4 AA repeats of C-C-X-P"
SQ SEQUENCE 165 AA; 15150 MW; 717A45732B1431C5 CRC64;
MGCCGCSEGC GSGCGGCGSG CGGCGSGCGG CGSSCCVPVC CCKPVCCCVP ACSCSSCGSC
GGSKGGCGSC GGSKGGCGSC GGSKGGCGSC GCSQCSCYKP CCCSSGCGSS CCQSSCCKPC
CCQSSCCKPC CCSSGCGSSC CQSSCCNPCC SQSSCCVPVC CQCKI
