KRA59_HUMAN
ID KRA59_HUMAN Reviewed; 169 AA.
AC P26371; Q14564; Q3MIP8;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1992, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Keratin-associated protein 5-9;
DE AltName: Full=Keratin, cuticle, ultrahigh sulfur 1;
DE AltName: Full=Keratin, ultra high-sulfur matrix protein A;
DE AltName: Full=Keratin-associated protein 5.9;
DE AltName: Full=UHS keratin A;
DE Short=UHS KerA;
DE AltName: Full=Ultrahigh sulfur keratin-associated protein 5.9;
GN Name=KRTAP5-9; Synonyms=KAP5.9, KRN1, KRTAP5.9, UHSK1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Hair follicle;
RX PubMed=1703541; DOI=10.1083/jcb.111.6.2587;
RA McKinnon P.J., Powell B.C., Rogers G.E.;
RT "Structure and expression of genes for a class of cysteine-rich proteins of
RT the cuticle layers of differentiating wool and hair follicles.";
RL J. Cell Biol. 111:2587-2600(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10023043; DOI=10.1016/s0378-1119(98)00616-7;
RA Perez C., Auriol J., Gerst C., Bernard B.A., Egly J.-M.;
RT "Genomic organization and promoter characterization of two human UHS
RT keratin genes.";
RL Gene 227:137-148(1999).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA], AND VARIANT CYS-40.
RC TISSUE=Testis;
RA Drabent B., Doenecke D.;
RL Submitted (DEC-1991) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC TISSUE=Hair root;
RX PubMed=15144888; DOI=10.1016/j.bbrc.2004.04.074;
RA Yahagi S., Shibuya K., Obayashi I., Masaki H., Kurata Y., Kudoh J.,
RA Shimizu N.;
RT "Identification of two novel clusters of ultrahigh-sulfur keratin-
RT associated protein genes on human chromosome 11.";
RL Biochem. Biophys. Res. Commun. 318:655-664(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated protein (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins.
CC -!- INTERACTION:
CC P26371; O43184-4: ADAM12; NbExp=3; IntAct=EBI-3958099, EBI-12006944;
CC P26371; Q6UY14-3: ADAMTSL4; NbExp=8; IntAct=EBI-3958099, EBI-10173507;
CC P26371; Q6ZMM2: ADAMTSL5; NbExp=3; IntAct=EBI-3958099, EBI-9075891;
CC P26371; P43353: ALDH3B1; NbExp=3; IntAct=EBI-3958099, EBI-2558314;
CC P26371; P05187: ALPP; NbExp=6; IntAct=EBI-3958099, EBI-1211484;
CC P26371; Q7Z3C6: ATG9A; NbExp=3; IntAct=EBI-3958099, EBI-727146;
CC P26371; Q9BXY8: BEX2; NbExp=3; IntAct=EBI-3958099, EBI-745073;
CC P26371; A8K571: BMP7; NbExp=3; IntAct=EBI-3958099, EBI-10174327;
CC P26371; P18075: BMP7; NbExp=3; IntAct=EBI-3958099, EBI-1035195;
CC P26371; Q5T681: C10orf62; NbExp=3; IntAct=EBI-3958099, EBI-744052;
CC P26371; Q6NUJ2: C11orf87; NbExp=3; IntAct=EBI-3958099, EBI-6660291;
CC P26371; Q8NEC5: CATSPER1; NbExp=6; IntAct=EBI-3958099, EBI-744545;
CC P26371; Q9UKJ5: CHIC2; NbExp=6; IntAct=EBI-3958099, EBI-741528;
CC P26371; Q9H2X0: CHRD; NbExp=6; IntAct=EBI-3958099, EBI-947551;
CC P26371; P07510-2: CHRNG; NbExp=3; IntAct=EBI-3958099, EBI-11979451;
CC P26371; P61024: CKS1B; NbExp=3; IntAct=EBI-3958099, EBI-456371;
CC P26371; Q8NE01: CNNM3; NbExp=6; IntAct=EBI-3958099, EBI-741032;
CC P26371; P27658: COL8A1; NbExp=3; IntAct=EBI-3958099, EBI-747133;
CC P26371; P21964-2: COMT; NbExp=3; IntAct=EBI-3958099, EBI-10200977;
CC P26371; Q9UGL9: CRCT1; NbExp=6; IntAct=EBI-3958099, EBI-713677;
CC P26371; Q02930-3: CREB5; NbExp=3; IntAct=EBI-3958099, EBI-10192698;
CC P26371; P06850: CRH; NbExp=3; IntAct=EBI-3958099, EBI-3870390;
CC P26371; Q49AN0: CRY2; NbExp=3; IntAct=EBI-3958099, EBI-2212355;
CC P26371; Q9NSA3: CTNNBIP1; NbExp=3; IntAct=EBI-3958099, EBI-747082;
CC P26371; Q9UBR2: CTSZ; NbExp=8; IntAct=EBI-3958099, EBI-8636823;
CC P26371; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-3958099, EBI-3867333;
CC P26371; Q9UHG0: DCDC2; NbExp=3; IntAct=EBI-3958099, EBI-10303987;
CC P26371; Q96LJ7: DHRS1; NbExp=3; IntAct=EBI-3958099, EBI-746300;
CC P26371; Q9NQL9: DMRT3; NbExp=3; IntAct=EBI-3958099, EBI-9679045;
CC P26371; Q13609: DNASE1L3; NbExp=3; IntAct=EBI-3958099, EBI-9512718;
CC P26371; Q92608: DOCK2; NbExp=6; IntAct=EBI-3958099, EBI-448771;
CC P26371; Q9NPA0: EMC7; NbExp=3; IntAct=EBI-3958099, EBI-6309137;
CC P26371; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-3958099, EBI-744099;
CC P26371; Q6UWV6: ENPP7; NbExp=3; IntAct=EBI-3958099, EBI-12047821;
CC P26371; P16930: FAH; NbExp=3; IntAct=EBI-3958099, EBI-4397076;
CC P26371; Q9H5Z6: FAM124B; NbExp=3; IntAct=EBI-3958099, EBI-741626;
CC P26371; Q3B820: FAM161A; NbExp=6; IntAct=EBI-3958099, EBI-719941;
CC P26371; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-3958099, EBI-10247271;
CC P26371; Q5HYJ3: FAM76B; NbExp=3; IntAct=EBI-3958099, EBI-751192;
CC P26371; Q5HYJ3-3: FAM76B; NbExp=3; IntAct=EBI-3958099, EBI-11956087;
CC P26371; P49771: FLT3LG; NbExp=3; IntAct=EBI-3958099, EBI-724977;
CC P26371; Q86UU5: GGN; NbExp=3; IntAct=EBI-3958099, EBI-10259069;
CC P26371; P43220: GLP1R; NbExp=3; IntAct=EBI-3958099, EBI-7466542;
CC P26371; O76003: GLRX3; NbExp=8; IntAct=EBI-3958099, EBI-374781;
CC P26371; Q9Y223: GNE; NbExp=3; IntAct=EBI-3958099, EBI-4291090;
CC P26371; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-3958099, EBI-11975289;
CC P26371; P28799: GRN; NbExp=3; IntAct=EBI-3958099, EBI-747754;
CC P26371; O15499: GSC2; NbExp=3; IntAct=EBI-3958099, EBI-19954058;
CC P26371; Q9UBP5: HEY2; NbExp=3; IntAct=EBI-3958099, EBI-750630;
CC P26371; Q03014: HHEX; NbExp=3; IntAct=EBI-3958099, EBI-747421;
CC P26371; P50747: HLCS; NbExp=3; IntAct=EBI-3958099, EBI-3915568;
CC P26371; P49639: HOXA1; NbExp=12; IntAct=EBI-3958099, EBI-740785;
CC P26371; P17482: HOXB9; NbExp=3; IntAct=EBI-3958099, EBI-745290;
CC P26371; P37235: HPCAL1; NbExp=3; IntAct=EBI-3958099, EBI-749311;
CC P26371; Q9H2F3: HSD3B7; NbExp=3; IntAct=EBI-3958099, EBI-3918847;
CC P26371; P10809: HSPD1; NbExp=3; IntAct=EBI-3958099, EBI-352528;
CC P26371; P24592: IGFBP6; NbExp=3; IntAct=EBI-3958099, EBI-947015;
CC P26371; Q15040: JOSD1; NbExp=3; IntAct=EBI-3958099, EBI-2510602;
CC P26371; Q2WGJ6: KLHL38; NbExp=6; IntAct=EBI-3958099, EBI-6426443;
CC P26371; O60259: KLK8; NbExp=3; IntAct=EBI-3958099, EBI-3915857;
CC P26371; Q5T749: KPRP; NbExp=3; IntAct=EBI-3958099, EBI-10981970;
CC P26371; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-3958099, EBI-11749135;
CC P26371; P60014: KRTAP10-10; NbExp=3; IntAct=EBI-3958099, EBI-11955579;
CC P26371; P60412: KRTAP10-11; NbExp=6; IntAct=EBI-3958099, EBI-10217483;
CC P26371; P60370: KRTAP10-5; NbExp=8; IntAct=EBI-3958099, EBI-10172150;
CC P26371; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-3958099, EBI-12012928;
CC P26371; P60409: KRTAP10-7; NbExp=5; IntAct=EBI-3958099, EBI-10172290;
CC P26371; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-3958099, EBI-10171774;
CC P26371; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-3958099, EBI-10172052;
CC P26371; Q8IUC1: KRTAP11-1; NbExp=4; IntAct=EBI-3958099, EBI-1052037;
CC P26371; P59990: KRTAP12-1; NbExp=6; IntAct=EBI-3958099, EBI-10210845;
CC P26371; P59991: KRTAP12-2; NbExp=6; IntAct=EBI-3958099, EBI-10176379;
CC P26371; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-3958099, EBI-11953334;
CC P26371; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-3958099, EBI-14065470;
CC P26371; Q9BYQ6: KRTAP4-11; NbExp=6; IntAct=EBI-3958099, EBI-10302392;
CC P26371; Q9BQ66: KRTAP4-12; NbExp=8; IntAct=EBI-3958099, EBI-739863;
CC P26371; Q9BYR5: KRTAP4-2; NbExp=8; IntAct=EBI-3958099, EBI-10172511;
CC P26371; Q9BYR3: KRTAP4-4; NbExp=3; IntAct=EBI-3958099, EBI-11958132;
CC P26371; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-3958099, EBI-11993254;
CC P26371; Q6L8G4: KRTAP5-11; NbExp=3; IntAct=EBI-3958099, EBI-11993296;
CC P26371; Q701N4: KRTAP5-2; NbExp=3; IntAct=EBI-3958099, EBI-11958178;
CC P26371; Q6L8H2: KRTAP5-3; NbExp=3; IntAct=EBI-3958099, EBI-11974251;
CC P26371; Q6L8H1: KRTAP5-4; NbExp=6; IntAct=EBI-3958099, EBI-11963072;
CC P26371; Q6L8G9: KRTAP5-6; NbExp=9; IntAct=EBI-3958099, EBI-10250562;
CC P26371; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-3958099, EBI-3958099;
CC P26371; Q9BYQ4: KRTAP9-2; NbExp=6; IntAct=EBI-3958099, EBI-1044640;
CC P26371; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-3958099, EBI-1043191;
CC P26371; Q9BYQ2: KRTAP9-4; NbExp=3; IntAct=EBI-3958099, EBI-10185730;
CC P26371; Q9BYQ0: KRTAP9-8; NbExp=6; IntAct=EBI-3958099, EBI-11958364;
CC P26371; Q5T7P2: LCE1A; NbExp=3; IntAct=EBI-3958099, EBI-11962058;
CC P26371; Q5T7P3: LCE1B; NbExp=10; IntAct=EBI-3958099, EBI-10245913;
CC P26371; Q5T751: LCE1C; NbExp=3; IntAct=EBI-3958099, EBI-12224199;
CC P26371; Q5T752: LCE1D; NbExp=3; IntAct=EBI-3958099, EBI-11741311;
CC P26371; Q5T753: LCE1E; NbExp=6; IntAct=EBI-3958099, EBI-11955335;
CC P26371; Q5T754: LCE1F; NbExp=6; IntAct=EBI-3958099, EBI-11958008;
CC P26371; Q5TA79: LCE2A; NbExp=9; IntAct=EBI-3958099, EBI-10246607;
CC P26371; O14633: LCE2B; NbExp=6; IntAct=EBI-3958099, EBI-11478468;
CC P26371; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-3958099, EBI-11973993;
CC P26371; Q5TA82: LCE2D; NbExp=3; IntAct=EBI-3958099, EBI-10246750;
CC P26371; Q5TA76: LCE3A; NbExp=6; IntAct=EBI-3958099, EBI-9394625;
CC P26371; Q5TA77: LCE3B; NbExp=4; IntAct=EBI-3958099, EBI-11974495;
CC P26371; Q5T5A8: LCE3C; NbExp=10; IntAct=EBI-3958099, EBI-10245291;
CC P26371; Q9BYE3: LCE3D; NbExp=3; IntAct=EBI-3958099, EBI-6658837;
CC P26371; Q5T5B0: LCE3E; NbExp=9; IntAct=EBI-3958099, EBI-10245456;
CC P26371; Q5TA78: LCE4A; NbExp=6; IntAct=EBI-3958099, EBI-10246358;
CC P26371; Q5TCM9: LCE5A; NbExp=6; IntAct=EBI-3958099, EBI-11955689;
CC P26371; Q5T871: LELP1; NbExp=3; IntAct=EBI-3958099, EBI-18115868;
CC P26371; Q96FE5: LINGO1; NbExp=3; IntAct=EBI-3958099, EBI-719955;
CC P26371; Q8TBB1: LNX1; NbExp=3; IntAct=EBI-3958099, EBI-739832;
CC P26371; O94772: LY6H; NbExp=3; IntAct=EBI-3958099, EBI-724687;
CC P26371; O60336: MAPKBP1; NbExp=6; IntAct=EBI-3958099, EBI-947402;
CC P26371; P50222: MEOX2; NbExp=3; IntAct=EBI-3958099, EBI-748397;
CC P26371; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-3958099, EBI-16439278;
CC P26371; Q13875-3: MOBP; NbExp=3; IntAct=EBI-3958099, EBI-12013470;
CC P26371; Q549C5: MST065; NbExp=3; IntAct=EBI-3958099, EBI-10243297;
CC P26371; Q8N339: MT1M; NbExp=3; IntAct=EBI-3958099, EBI-3911571;
CC P26371; Q8IW45: NAXD; NbExp=3; IntAct=EBI-3958099, EBI-8650724;
CC P26371; Q969V3-2: NCLN; NbExp=3; IntAct=EBI-3958099, EBI-10281480;
CC P26371; Q92692: NECTIN2; NbExp=3; IntAct=EBI-3958099, EBI-718419;
CC P26371; Q9NQS3-2: NECTIN3; NbExp=3; IntAct=EBI-3958099, EBI-12106440;
CC P26371; Q969G9: NKD1; NbExp=3; IntAct=EBI-3958099, EBI-1538217;
CC P26371; Q9UBE8: NLK; NbExp=3; IntAct=EBI-3958099, EBI-366978;
CC P26371; P48645: NMU; NbExp=6; IntAct=EBI-3958099, EBI-10210351;
CC P26371; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-3958099, EBI-945833;
CC P26371; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-3958099, EBI-22310682;
CC P26371; P48146: NPBWR2; NbExp=3; IntAct=EBI-3958099, EBI-10210114;
CC P26371; Q9NQX5: NPDC1; NbExp=6; IntAct=EBI-3958099, EBI-748927;
CC P26371; Q92570: NR4A3; NbExp=3; IntAct=EBI-3958099, EBI-13644623;
CC P26371; Q96HA8: NTAQ1; NbExp=6; IntAct=EBI-3958099, EBI-741158;
CC P26371; Q9P121: NTM; NbExp=3; IntAct=EBI-3958099, EBI-4315078;
CC P26371; Q9HB63: NTN4; NbExp=4; IntAct=EBI-3958099, EBI-743459;
CC P26371; Q9HB63-3: NTN4; NbExp=3; IntAct=EBI-3958099, EBI-10310092;
CC P26371; Q7Z417: NUFIP2; NbExp=5; IntAct=EBI-3958099, EBI-1210753;
CC P26371; P32242: OTX1; NbExp=8; IntAct=EBI-3958099, EBI-740446;
CC P26371; Q99571: P2RX4; NbExp=3; IntAct=EBI-3958099, EBI-2828248;
CC P26371; Q15077: P2RY6; NbExp=3; IntAct=EBI-3958099, EBI-10235794;
CC P26371; P07237: P4HB; NbExp=3; IntAct=EBI-3958099, EBI-395883;
CC P26371; Q92824: PCSK5; NbExp=3; IntAct=EBI-3958099, EBI-751290;
CC P26371; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-3958099, EBI-11956269;
CC P26371; O76083-2: PDE9A; NbExp=3; IntAct=EBI-3958099, EBI-11524542;
CC P26371; P17858: PFKL; NbExp=3; IntAct=EBI-3958099, EBI-487243;
CC P26371; Q9HCN3: PGAP6; NbExp=3; IntAct=EBI-3958099, EBI-10310808;
CC P26371; A2BDE7: PHLDA1; NbExp=3; IntAct=EBI-3958099, EBI-14084211;
CC P26371; Q13526: PIN1; NbExp=3; IntAct=EBI-3958099, EBI-714158;
CC P26371; A0JP26: POTEB3; NbExp=3; IntAct=EBI-3958099, EBI-18165900;
CC P26371; Q12837: POU4F2; NbExp=3; IntAct=EBI-3958099, EBI-17236143;
CC P26371; O43741: PRKAB2; NbExp=6; IntAct=EBI-3958099, EBI-1053424;
CC P26371; P25786: PSMA1; NbExp=6; IntAct=EBI-3958099, EBI-359352;
CC P26371; Q8WUK0: PTPMT1; NbExp=6; IntAct=EBI-3958099, EBI-7199479;
CC P26371; O60896: RAMP3; NbExp=3; IntAct=EBI-3958099, EBI-720447;
CC P26371; Q9Y272: RASD1; NbExp=3; IntAct=EBI-3958099, EBI-740818;
CC P26371; O76081: RGS20; NbExp=3; IntAct=EBI-3958099, EBI-1052678;
CC P26371; O76081-6: RGS20; NbExp=6; IntAct=EBI-3958099, EBI-10178530;
CC P26371; Q6ZNA4: RNF111; NbExp=5; IntAct=EBI-3958099, EBI-2129175;
CC P26371; Q8WTV0: SCARB1; NbExp=3; IntAct=EBI-3958099, EBI-78657;
CC P26371; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-3958099, EBI-748391;
CC P26371; A0A0S2Z4U3: SDC3; NbExp=9; IntAct=EBI-3958099, EBI-10204280;
CC P26371; O00560: SDCBP; NbExp=6; IntAct=EBI-3958099, EBI-727004;
CC P26371; Q13214-2: SEMA3B; NbExp=3; IntAct=EBI-3958099, EBI-11017428;
CC P26371; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-3958099, EBI-10313866;
CC P26371; Q9NUL5-4: SHFL; NbExp=3; IntAct=EBI-3958099, EBI-11955083;
CC P26371; Q86YT5: SLC13A5; NbExp=3; IntAct=EBI-3958099, EBI-12002412;
CC P26371; Q8IY34: SLC15A3; NbExp=3; IntAct=EBI-3958099, EBI-12179023;
CC P26371; A1A5C7: SLC22A23; NbExp=3; IntAct=EBI-3958099, EBI-10171756;
CC P26371; Q9UBX3: SLC25A10; NbExp=3; IntAct=EBI-3958099, EBI-750394;
CC P26371; Q9UBX3-2: SLC25A10; NbExp=3; IntAct=EBI-3958099, EBI-12056597;
CC P26371; P49901: SMCP; NbExp=8; IntAct=EBI-3958099, EBI-750494;
CC P26371; A0A024R4B0: SPATA3; NbExp=3; IntAct=EBI-3958099, EBI-14123856;
CC P26371; P20155: SPINK2; NbExp=3; IntAct=EBI-3958099, EBI-10200479;
CC P26371; O43609: SPRY1; NbExp=3; IntAct=EBI-3958099, EBI-3866665;
CC P26371; O43597: SPRY2; NbExp=3; IntAct=EBI-3958099, EBI-742487;
CC P26371; Q8IV04: TBC1D10C; NbExp=3; IntAct=EBI-3958099, EBI-10261452;
CC P26371; Q15560: TCEA2; NbExp=3; IntAct=EBI-3958099, EBI-710310;
CC P26371; Q8N8B7: TCEANC; NbExp=3; IntAct=EBI-3958099, EBI-954696;
CC P26371; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-3958099, EBI-11955057;
CC P26371; P22735: TGM1; NbExp=3; IntAct=EBI-3958099, EBI-2562368;
CC P26371; A5PKU2: TUSC5; NbExp=3; IntAct=EBI-3958099, EBI-11988865;
CC P26371; Q06418: TYRO3; NbExp=5; IntAct=EBI-3958099, EBI-3951628;
CC P26371; Q7KZS0: UBE2I; NbExp=3; IntAct=EBI-3958099, EBI-10180829;
CC P26371; Q9UBK9: UXT; NbExp=3; IntAct=EBI-3958099, EBI-357355;
CC P26371; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-3958099, EBI-11957238;
CC P26371; O96014: WNT11; NbExp=3; IntAct=EBI-3958099, EBI-8058160;
CC P26371; Q9GZM5: YIPF3; NbExp=3; IntAct=EBI-3958099, EBI-743787;
CC P26371; O43167: ZBTB24; NbExp=3; IntAct=EBI-3958099, EBI-744471;
CC P26371; Q9BQ24: ZFYVE21; NbExp=3; IntAct=EBI-3958099, EBI-2849569;
CC P26371; Q15973: ZNF124; NbExp=6; IntAct=EBI-3958099, EBI-2555767;
CC P26371; Q14584: ZNF266; NbExp=3; IntAct=EBI-3958099, EBI-7115319;
CC P26371; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-3958099, EBI-347633;
CC P26371; Q96IQ9: ZNF414; NbExp=3; IntAct=EBI-3958099, EBI-744257;
CC P26371; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-3958099, EBI-740727;
CC P26371; Q8NDP4: ZNF439; NbExp=6; IntAct=EBI-3958099, EBI-747580;
CC P26371; Q8IYI8: ZNF440; NbExp=3; IntAct=EBI-3958099, EBI-726439;
CC P26371; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-3958099, EBI-745520;
CC P26371; Q96SQ5: ZNF587; NbExp=6; IntAct=EBI-3958099, EBI-6427977;
CC P26371; Q8N720: ZNF655; NbExp=3; IntAct=EBI-3958099, EBI-625509;
CC P26371; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-3958099, EBI-11090299;
CC P26371; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-3958099, EBI-11962574;
CC P26371; Q5BKY6; NbExp=3; IntAct=EBI-3958099, EBI-10243533;
CC P26371; Q9NWL9; NbExp=3; IntAct=EBI-3958099, EBI-10315054;
CC P26371; P09022: Hoxa1; Xeno; NbExp=3; IntAct=EBI-3958099, EBI-3957603;
CC -!- TISSUE SPECIFICITY: Restricted to hair root, not detected in any other
CC tissues. Expressed in cuticle layers of differentiating hair follicles.
CC {ECO:0000269|PubMed:15144888}.
CC -!- DEVELOPMENTAL STAGE: At a late stage of fiber differentiation.
CC -!- SIMILARITY: Belongs to the KRTAP type 5 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X55293; CAA39005.1; -; Genomic_DNA.
DR EMBL; AJ006693; CAA07189.1; -; Genomic_DNA.
DR EMBL; X63755; CAA45283.1; -; mRNA.
DR EMBL; AB126078; BAD20205.1; -; mRNA.
DR EMBL; BC069531; AAH69531.1; -; mRNA.
DR EMBL; BC101744; AAI01745.2; -; mRNA.
DR CCDS; CCDS53677.1; -.
DR PIR; S18946; S18946.
DR RefSeq; NP_005544.4; NM_005553.3.
DR AlphaFoldDB; P26371; -.
DR BioGRID; 110044; 199.
DR IntAct; P26371; 195.
DR MINT; P26371; -.
DR iPTMnet; P26371; -.
DR PhosphoSitePlus; P26371; -.
DR BioMuta; KRTAP5-9; -.
DR MassIVE; P26371; -.
DR PaxDb; P26371; -.
DR PeptideAtlas; P26371; -.
DR PRIDE; P26371; -.
DR DNASU; 3846; -.
DR Ensembl; ENST00000528743.4; ENSP00000431443.3; ENSG00000254997.4.
DR GeneID; 3846; -.
DR KEGG; hsa:3846; -.
DR MANE-Select; ENST00000528743.4; ENSP00000431443.3; NM_005553.4; NP_005544.4.
DR UCSC; uc001oqs.2; human.
DR CTD; 3846; -.
DR DisGeNET; 3846; -.
DR GeneCards; KRTAP5-9; -.
DR HGNC; HGNC:23604; KRTAP5-9.
DR HPA; ENSG00000254997; Tissue enhanced (testis).
DR MIM; 148021; gene.
DR neXtProt; NX_P26371; -.
DR OpenTargets; ENSG00000254997; -.
DR PharmGKB; PA134946701; -.
DR VEuPathDB; HostDB:ENSG00000254997; -.
DR eggNOG; KOG4726; Eukaryota.
DR GeneTree; ENSGT00950000186550; -.
DR HOGENOM; CLU_097966_0_0_1; -.
DR OMA; CGPSCCA; -.
DR PathwayCommons; P26371; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; P26371; -.
DR BioGRID-ORCS; 3846; 72 hits in 1053 CRISPR screens.
DR GenomeRNAi; 3846; -.
DR Pharos; P26371; Tdark.
DR PRO; PR:P26371; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; P26371; protein.
DR Bgee; ENSG00000254997; Expressed in mucosa of transverse colon and 97 other tissues.
DR Genevisible; P26371; HS.
DR GO; GO:0005829; C:cytosol; TAS:Reactome.
DR GO; GO:0045095; C:keratin filament; IEA:InterPro.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0008544; P:epidermis development; TAS:ProtInc.
DR InterPro; IPR002494; KAP.
DR PANTHER; PTHR23262; PTHR23262; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..169
FT /note="Keratin-associated protein 5-9"
FT /id="PRO_0000184107"
FT REPEAT 35..38
FT /note="1"
FT REPEAT 41..44
FT /note="2"
FT REPEAT 47..50
FT /note="3"
FT REPEAT 82..85
FT /note="4"
FT REPEAT 101..104
FT /note="5"
FT REPEAT 130..134
FT /note="6"
FT REPEAT 149..152
FT /note="7"
FT REPEAT 159..162
FT /note="8"
FT REGION 35..162
FT /note="8 X 4 AA repeats of C-C-X-P"
FT VARIANT 8
FT /note="G -> R (in dbSNP:rs34213141)"
FT /id="VAR_053731"
FT VARIANT 40
FT /note="Y -> C (in dbSNP:rs10792769)"
FT /evidence="ECO:0000269|Ref.3"
FT /id="VAR_053732"
SQ SEQUENCE 169 AA; 16276 MW; 219B14FEEB49D4AB CRC64;
MGCCGCSGGC GSSCGGCDSS CGSCGSGCRG CGPSCCAPVY CCKPVCCCVP ACSCSSCGKR
GCGSCGGSKG GCGSCGCSQC SCCKPCCCSS GCGSSCCQCS CCKPYCSQCS CCKPCCSSSG
RGSSCCQSSC CKPCCSSSGC GSSCCQSSCC KPCCSQSRCC VPVCYQCKI
