KRA61_HUMAN
ID KRA61_HUMAN Reviewed; 71 AA.
AC Q3LI64;
DT 21-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Keratin-associated protein 6-1;
GN Name=KRTAP6-1; Synonyms=C21orf103, KAP6.1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hair root;
RA Obayashi I., Shibuya K., Minoshima S., Kudoh J., Shimizu N.;
RT "Identification of complete keratin-associated protein (KAP) gene cluster
RT spanning 800 kb region on human chromosome 21q22.11.";
RL Submitted (NOV-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- INTERACTION:
CC Q3LI64; Q9NYG5-2: ANAPC11; NbExp=3; IntAct=EBI-12111050, EBI-12224467;
CC Q3LI64; P41238: APOBEC1; NbExp=3; IntAct=EBI-12111050, EBI-12819523;
CC Q3LI64; Q03989: ARID5A; NbExp=3; IntAct=EBI-12111050, EBI-948603;
CC Q3LI64; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-12111050, EBI-742750;
CC Q3LI64; O14503: BHLHE40; NbExp=3; IntAct=EBI-12111050, EBI-711810;
CC Q3LI64; Q9UQM7: CAMK2A; NbExp=3; IntAct=EBI-12111050, EBI-1383687;
CC Q3LI64; Q13555-5: CAMK2G; NbExp=3; IntAct=EBI-12111050, EBI-12020154;
CC Q3LI64; Q8NEC5: CATSPER1; NbExp=3; IntAct=EBI-12111050, EBI-744545;
CC Q3LI64; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-12111050, EBI-744556;
CC Q3LI64; Q8N4L8: CCDC24; NbExp=3; IntAct=EBI-12111050, EBI-1104933;
CC Q3LI64; P32320: CDA; NbExp=3; IntAct=EBI-12111050, EBI-9250559;
CC Q3LI64; Q8N6W0: CELF5; NbExp=5; IntAct=EBI-12111050, EBI-12139335;
CC Q3LI64; Q02930-3: CREB5; NbExp=5; IntAct=EBI-12111050, EBI-10192698;
CC Q3LI64; P02511: CRYAB; NbExp=3; IntAct=EBI-12111050, EBI-739060;
CC Q3LI64; A8MQ03: CYSRT1; NbExp=6; IntAct=EBI-12111050, EBI-3867333;
CC Q3LI64; Q15038: DAZAP2; NbExp=8; IntAct=EBI-12111050, EBI-724310;
CC Q3LI64; Q86UW9: DTX2; NbExp=3; IntAct=EBI-12111050, EBI-740376;
CC Q3LI64; Q12805: EFEMP1; NbExp=3; IntAct=EBI-12111050, EBI-536772;
CC Q3LI64; Q03828: EVX2; NbExp=3; IntAct=EBI-12111050, EBI-17280301;
CC Q3LI64; A0A0C3SFZ9: FCHO1; NbExp=3; IntAct=EBI-12111050, EBI-11977403;
CC Q3LI64; Q9BZE0: GLIS2; NbExp=3; IntAct=EBI-12111050, EBI-7251368;
CC Q3LI64; Q8NEA6-2: GLIS3; NbExp=3; IntAct=EBI-12111050, EBI-12232117;
CC Q3LI64; Q9Y223-2: GNE; NbExp=3; IntAct=EBI-12111050, EBI-11975289;
CC Q3LI64; Q13227: GPS2; NbExp=3; IntAct=EBI-12111050, EBI-713355;
CC Q3LI64; P28799: GRN; NbExp=3; IntAct=EBI-12111050, EBI-747754;
CC Q3LI64; A0A087WSW0: HELT; NbExp=3; IntAct=EBI-12111050, EBI-12057631;
CC Q3LI64; Q9UBP5: HEY2; NbExp=3; IntAct=EBI-12111050, EBI-750630;
CC Q3LI64; Q03014: HHEX; NbExp=3; IntAct=EBI-12111050, EBI-747421;
CC Q3LI64; P49639: HOXA1; NbExp=3; IntAct=EBI-12111050, EBI-740785;
CC Q3LI64; P31273: HOXC8; NbExp=3; IntAct=EBI-12111050, EBI-1752118;
CC Q3LI64; Q6UXX5: ITIH6; NbExp=3; IntAct=EBI-12111050, EBI-11028396;
CC Q3LI64; Q5T749: KPRP; NbExp=3; IntAct=EBI-12111050, EBI-10981970;
CC Q3LI64; Q8IUC1: KRTAP11-1; NbExp=3; IntAct=EBI-12111050, EBI-1052037;
CC Q3LI64; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-12111050, EBI-10210845;
CC Q3LI64; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-12111050, EBI-11953334;
CC Q3LI64; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-12111050, EBI-3957672;
CC Q3LI64; Q9BYR8: KRTAP3-1; NbExp=3; IntAct=EBI-12111050, EBI-9996449;
CC Q3LI64; Q9BYR2: KRTAP4-5; NbExp=3; IntAct=EBI-12111050, EBI-11993254;
CC Q3LI64; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-12111050, EBI-11962084;
CC Q3LI64; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-12111050, EBI-2341787;
CC Q3LI64; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-12111050, EBI-716006;
CC Q3LI64; Q8NDC0: MAPK1IP1L; NbExp=3; IntAct=EBI-12111050, EBI-741424;
CC Q3LI64; Q71SY5: MED25; NbExp=3; IntAct=EBI-12111050, EBI-394558;
CC Q3LI64; O14770-4: MEIS2; NbExp=3; IntAct=EBI-12111050, EBI-8025850;
CC Q3LI64; Q8IVT4: MGC50722; NbExp=3; IntAct=EBI-12111050, EBI-14086479;
CC Q3LI64; Q8TDC0: MYOZ3; NbExp=3; IntAct=EBI-12111050, EBI-5662487;
CC Q3LI64; Q96HR8: NAF1; NbExp=3; IntAct=EBI-12111050, EBI-2515597;
CC Q3LI64; A8MTQ0: NOTO; NbExp=3; IntAct=EBI-12111050, EBI-17490746;
CC Q3LI64; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-12111050, EBI-741158;
CC Q3LI64; Q7RTU3: OLIG3; NbExp=3; IntAct=EBI-12111050, EBI-10225049;
CC Q3LI64; Q8N2R0-2: OSR2; NbExp=3; IntAct=EBI-12111050, EBI-12850348;
CC Q3LI64; P32242: OTX1; NbExp=3; IntAct=EBI-12111050, EBI-740446;
CC Q3LI64; Q7Z4N8: P4HA3; NbExp=3; IntAct=EBI-12111050, EBI-10181968;
CC Q3LI64; Q9HBE1-4: PATZ1; NbExp=3; IntAct=EBI-12111050, EBI-11022007;
CC Q3LI64; Q13087: PDIA2; NbExp=3; IntAct=EBI-12111050, EBI-1752525;
CC Q3LI64; P78337: PITX1; NbExp=3; IntAct=EBI-12111050, EBI-748265;
CC Q3LI64; Q99697-2: PITX2; NbExp=3; IntAct=EBI-12111050, EBI-12138495;
CC Q3LI64; Q9NRY6: PLSCR3; NbExp=3; IntAct=EBI-12111050, EBI-750734;
CC Q3LI64; Q9NRQ2: PLSCR4; NbExp=4; IntAct=EBI-12111050, EBI-769257;
CC Q3LI64; P28069: POU1F1; NbExp=3; IntAct=EBI-12111050, EBI-8673859;
CC Q3LI64; Q12837: POU4F2; NbExp=3; IntAct=EBI-12111050, EBI-17236143;
CC Q3LI64; Q9NZ81: PRR13; NbExp=5; IntAct=EBI-12111050, EBI-740924;
CC Q3LI64; P0CG20: PRR35; NbExp=3; IntAct=EBI-12111050, EBI-11986293;
CC Q3LI64; Q6ZRY4: RBPMS2; NbExp=3; IntAct=EBI-12111050, EBI-11987469;
CC Q3LI64; Q9BQY4: RHOXF2; NbExp=5; IntAct=EBI-12111050, EBI-372094;
CC Q3LI64; Q92922: SMARCC1; NbExp=3; IntAct=EBI-12111050, EBI-355653;
CC Q3LI64; Q16637: SMN2; NbExp=3; IntAct=EBI-12111050, EBI-395421;
CC Q3LI64; P14678-2: SNRPB; NbExp=3; IntAct=EBI-12111050, EBI-372475;
CC Q3LI64; Q9NQB0-10: TCF7L2; NbExp=3; IntAct=EBI-12111050, EBI-11746252;
CC Q3LI64; Q9BXF9: TEKT3; NbExp=3; IntAct=EBI-12111050, EBI-8644516;
CC Q3LI64; Q96A09: TENT5B; NbExp=3; IntAct=EBI-12111050, EBI-752030;
CC Q3LI64; Q7Z6R9: TFAP2D; NbExp=3; IntAct=EBI-12111050, EBI-11952651;
CC Q3LI64; O43711: TLX3; NbExp=3; IntAct=EBI-12111050, EBI-3939165;
CC Q3LI64; Q15025: TNIP1; NbExp=3; IntAct=EBI-12111050, EBI-357849;
CC Q3LI64; Q9H0E2: TOLLIP; NbExp=5; IntAct=EBI-12111050, EBI-74615;
CC Q3LI64; Q8WVR3: TRAPPC14; NbExp=3; IntAct=EBI-12111050, EBI-719893;
CC Q3LI64; Q15645: TRIP13; NbExp=4; IntAct=EBI-12111050, EBI-358993;
CC Q3LI64; Q8IV45: UNC5CL; NbExp=3; IntAct=EBI-12111050, EBI-12238241;
CC Q3LI64; Q08AM6: VAC14; NbExp=3; IntAct=EBI-12111050, EBI-2107455;
CC Q3LI64; O95231: VENTX; NbExp=3; IntAct=EBI-12111050, EBI-10191303;
CC Q3LI64; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-12111050, EBI-11957216;
CC Q3LI64; A5D8V6: VPS37C; NbExp=3; IntAct=EBI-12111050, EBI-2559305;
CC Q3LI64; A0A0C4DGF1: ZBTB32; NbExp=5; IntAct=EBI-12111050, EBI-10188476;
CC Q3LI64; Q96K80: ZC3H10; NbExp=3; IntAct=EBI-12111050, EBI-742550;
CC Q3LI64; Q15915: ZIC1; NbExp=3; IntAct=EBI-12111050, EBI-11963196;
CC Q3LI64; Q96IQ9: ZNF414; NbExp=5; IntAct=EBI-12111050, EBI-744257;
CC -!- SIMILARITY: Belongs to the KRTAP type 6 family. {ECO:0000305}.
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DR EMBL; AB096954; BAE46369.1; -; mRNA.
DR CCDS; CCDS13602.1; -.
DR RefSeq; NP_853633.1; NM_181602.1.
DR AlphaFoldDB; Q3LI64; -.
DR BioGRID; 130649; 102.
DR IntAct; Q3LI64; 86.
DR STRING; 9606.ENSP00000332690; -.
DR iPTMnet; Q3LI64; -.
DR PhosphoSitePlus; Q3LI64; -.
DR BioMuta; KRTAP6-1; -.
DR MassIVE; Q3LI64; -.
DR PaxDb; Q3LI64; -.
DR PeptideAtlas; Q3LI64; -.
DR PRIDE; Q3LI64; -.
DR ProteomicsDB; 61765; -.
DR DNASU; 337966; -.
DR Ensembl; ENST00000329122.2; ENSP00000332690.2; ENSG00000184724.5.
DR GeneID; 337966; -.
DR KEGG; hsa:337966; -.
DR MANE-Select; ENST00000329122.2; ENSP00000332690.2; NM_181602.2; NP_853633.1.
DR UCSC; uc002yop.4; human.
DR CTD; 337966; -.
DR GeneCards; KRTAP6-1; -.
DR HGNC; HGNC:18931; KRTAP6-1.
DR HPA; ENSG00000184724; Tissue enriched (skin).
DR neXtProt; NX_Q3LI64; -.
DR PharmGKB; PA134988301; -.
DR VEuPathDB; HostDB:ENSG00000184724; -.
DR eggNOG; ENOG502TF3E; Eukaryota.
DR GeneTree; ENSGT00950000183372; -.
DR HOGENOM; CLU_182642_0_0_1; -.
DR OMA; YRSLCDY; -.
DR PathwayCommons; Q3LI64; -.
DR Reactome; R-HSA-6805567; Keratinization.
DR SignaLink; Q3LI64; -.
DR BioGRID-ORCS; 337966; 10 hits in 1058 CRISPR screens.
DR GenomeRNAi; 337966; -.
DR Pharos; Q3LI64; Tdark.
DR PRO; PR:Q3LI64; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q3LI64; protein.
DR Bgee; ENSG00000184724; Expressed in prefrontal cortex and 8 other tissues.
DR GO; GO:0005829; C:cytosol; HDA:UniProtKB.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0031424; P:keratinization; IEA:InterPro.
DR InterPro; IPR040313; KAP6.
DR PANTHER; PTHR31678; PTHR31678; 1.
PE 1: Evidence at protein level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..71
FT /note="Keratin-associated protein 6-1"
FT /id="PRO_0000223898"
SQ SEQUENCE 71 AA; 7279 MW; 233D648E50FB8858 CRC64;
MCGSYYGNYY GTPGYGFCGY GGLGYGYGGL GCGYGSCCGC GFRRLGCGYG YGSRSLCGYG
YGCGSGSGYY Y
