ID   KRA61_RABIT             Reviewed;          80 AA.
AC   Q02957;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Keratin-associated protein 6-1;
DE   AltName: Full=Keratin, glycine/tyrosine-rich of hair;
GN   Name=KRTAP6-1; Synonyms=KAP6-1;
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   TISSUE=Liver;
RX   PubMed=7680040; DOI=10.1016/s0021-9258(18)53639-5;
RA   Fratini A., Powell B.C., Rogers G.E.;
RT   "Sequence, expression, and evolutionary conservation of a gene encoding a
RT   glycine/tyrosine-rich keratin-associated protein of hair.";
RL   J. Biol. Chem. 268:4511-4518(1993).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with hair keratins.
CC   -!- DEVELOPMENTAL STAGE: KAP6 proteins are first expressed in
CC       differentiating hair shaft keratinocytes a considerable distance above
CC       the proliferative zone of the follicle bulb.
CC   -!- SIMILARITY: Belongs to the KRTAP type 6 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M95718; AAA31379.1; -; Genomic_DNA.
DR   PIR; B45466; B45466.
DR   RefSeq; NP_001164738.1; NM_001171267.1.
DR   AlphaFoldDB; Q02957; -.
DR   GeneID; 100328943; -.
DR   KEGG; ocu:100328943; -.
DR   CTD; 337966; -.
DR   Proteomes; UP000001811; Unplaced.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0031424; P:keratinization; IEA:InterPro.
DR   InterPro; IPR040313; KAP6.
DR   PANTHER; PTHR31678; PTHR31678; 1.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000305"
FT   CHAIN           2..80
FT                   /note="Keratin-associated protein 6-1"
FT                   /id="PRO_0000185222"
SQ   SEQUENCE   80 AA;  8274 MW;  65C4E99483AE0FAB CRC64;
     MCGYYGNYYG GRGYGCCGYG GLGYGYGGLG CGLGSYYGCG YRRLGCGYGC GYGYGYGSRS
     LCGCGYGYGS GYGSGFGYYY