ID   KRA61_SHEEP             Reviewed;          83 AA.
AC   Q02958;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 2.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Keratin-associated protein 6-1;
DE   AltName: Full=Keratin, glycine/tyrosine-rich of hair;
GN   Name=KRTAP6-1; Synonyms=KAP6-1;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Merino X Dorset Horn; TISSUE=Wool follicle;
RX   PubMed=7680040; DOI=10.1016/s0021-9258(18)53639-5;
RA   Fratini A., Powell B.C., Rogers G.E.;
RT   "Sequence, expression, and evolutionary conservation of a gene encoding a
RT   glycine/tyrosine-rich keratin-associated protein of hair.";
RL   J. Biol. Chem. 268:4511-4518(1993).
RN   [2]
RP   PROTEIN SEQUENCE OF 17-83.
RX   PubMed=1809119;
RA   Rogers G.E., Fietz M.J., Fratini A.;
RT   "Trichohyalin and matrix proteins.";
RL   Ann. N. Y. Acad. Sci. 642:64-81(1991).
CC   -!- FUNCTION: In the wool cortex, wool keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant wool shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of wool keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins.
CC   -!- SUBUNIT: Interacts with wool keratins.
CC   -!- DEVELOPMENTAL STAGE: The KAP6 proteins are first expressed in
CC       differentiating hair shaft keratinocytes, a considerable distance above
CC       the proliferative zone of the follicle bulb.
CC   -!- SIMILARITY: Belongs to the KRTAP type 6 family. {ECO:0000305}.
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DR   EMBL; M95719; AAA31554.1; -; Genomic_DNA.
DR   PIR; A45466; A45466.
DR   RefSeq; NP_001180328.1; NM_001193399.1.
DR   AlphaFoldDB; Q02958; -.
DR   PRIDE; Q02958; -.
DR   Ensembl; ENSOART00020002329; ENSOARP00020001940; ENSOARG00020001540.
DR   GeneID; 100499198; -.
DR   KEGG; oas:100499198; -.
DR   CTD; 337966; -.
DR   Proteomes; UP000002356; Unplaced.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0031424; P:keratinization; IEA:InterPro.
DR   InterPro; IPR040313; KAP6.
DR   PANTHER; PTHR31678; PTHR31678; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Keratin; Reference proteome; Repeat.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000305"
FT   CHAIN           2..83
FT                   /note="Keratin-associated protein 6-1"
FT                   /id="PRO_0000185223"
FT   REPEAT          9..15
FT                   /note="RPT 1-1"
FT   REPEAT          19..25
FT                   /note="RPT 1-2"
FT   REPEAT          44..55
FT                   /note="RPT 2-1"
FT   REPEAT          56..67
FT                   /note="RPT 2-2"
FT   CONFLICT        17
FT                   /note="Y -> G (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   83 AA;  8427 MW;  064E8002BE815DE6 CRC64;
     MCGYYGNYYG GLGCGSYSYG GLGCGYGSCY GSGFRRLGCG YGCGYGYGSR SLCGSGYGYG
     SRSLCGSGYG CGSGYGSGFG YYY