ID   KRA62_MOUSE             Reviewed;         159 AA.
AC   O08884;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1997, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Keratin-associated protein 6-2 {ECO:0000312|MGI:MGI:1330280};
DE   AltName: Full=High-glycine tyrosine keratin type II.4 {ECO:0000312|EMBL:BAA20281.1};
DE            Short=HGTp type II.4 {ECO:0000303|PubMed:9374545};
DE            Short=HgtpII.4;
GN   Name=Krtap6-2 {ECO:0000312|MGI:MGI:1330280};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAA20281.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Skin {ECO:0000312|EMBL:BAA20281.1};
RX   PubMed=9374545; DOI=10.1074/jbc.272.48.30512;
RA   Aoki N., Ito K., Ito M.;
RT   "Isolation and characterization of mouse high-glycine/tyrosine proteins.";
RL   J. Biol. Chem. 272:30512-30518(1997).
CC   -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC       embedded in an interfilamentous matrix, consisting of hair keratin-
CC       associated proteins (KRTAP), which are essential for the formation of a
CC       rigid and resistant hair shaft through their extensive disulfide bond
CC       cross-linking with abundant cysteine residues of hair keratins. The
CC       matrix proteins include the high-sulfur and high-glycine-tyrosine
CC       keratins. {ECO:0000305}.
CC   -!- SUBUNIT: Interacts with hair keratins. {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in skin during two hair growth cycles.
CC       Expression restricted to the cortical cells of hair follicles,
CC       appearing first in the cortical cells processing the flat nuclei
CC       located a few cells above the dermal papilla.
CC       {ECO:0000269|PubMed:9374545}.
CC   -!- SIMILARITY: Belongs to the KRTAP type 6 family.
CC       {ECO:0000250|UniProtKB:Q3LI66}.
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DR   EMBL; D89902; BAA20281.1; -; mRNA.
DR   RefSeq; NP_034803.2; NM_010673.2.
DR   AlphaFoldDB; O08884; -.
DR   STRING; 10090.ENSMUSP00000139661; -.
DR   iPTMnet; O08884; -.
DR   PhosphoSitePlus; O08884; -.
DR   PRIDE; O08884; -.
DR   ProteomicsDB; 264955; -.
DR   DNASU; 16701; -.
DR   GeneID; 16701; -.
DR   KEGG; mmu:16701; -.
DR   CTD; 337967; -.
DR   MGI; MGI:1330280; Krtap6-2.
DR   BioGRID-ORCS; 16701; 1 hit in 63 CRISPR screens.
DR   PRO; PR:O08884; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; O08884; protein.
DR   GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR   GO; GO:0001942; P:hair follicle development; IBA:GO_Central.
PE   2: Evidence at transcript level;
KW   Keratin; Reference proteome; Repeat.
FT   CHAIN           1..159
FT                   /note="Keratin-associated protein 6-2"
FT                   /id="PRO_0000361662"
FT   REGION          11..147
FT                   /note="66 X 2 AA repeats of G-[YCGS]"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   159 AA;  15262 MW;  2925AEB08A777BB9 CRC64;
     MCCNYYGNSC GYGCGYGSGY GSGYGCGSGS GYGCGYGSGY GCGYGSGYGC GSGSGYGCGY
     GSGYGCGYGS GYGCGYGSGY GCGYGSGYGC GYGSGYGCGY GSGYGCGYGS GYGCGYGSGY
     GSGYGSGYGS GCGCGYGSYY RSGCCGYGPS CYRRCYSCC