KRA65_MOUSE
ID KRA65_MOUSE Reviewed; 78 AA.
AC Q925H3;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Keratin-associated protein 6-5;
DE AltName: Full=Keratin-associated protein 16-8 {ECO:0000312|EMBL:AAI32613.1};
DE AltName: Full=Keratin-associated protein 16.8 {ECO:0000312|EMBL:AAK52896.1};
GN Name=Krtap6-5; Synonyms=Krtap16-8, Krtap16.8 {ECO:0000312|EMBL:AAK52896.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAK52896.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND INDUCTION.
RC STRAIN=FVB/NJ {ECO:0000312|EMBL:AAK52896.1};
RC TISSUE=Skin {ECO:0000269|PubMed:11290294};
RX PubMed=11290294; DOI=10.1242/dev.128.9.1547;
RA Tkatchenko A.V., Visconti R.P., Shang L., Papenbrock T., Pruett N.D.,
RA Ito T., Ogawa M., Awgulewitsch A.;
RT "Overexpression of Hoxc13 in differentiating keratinocytes results in
RT downregulation of a novel hair keratin gene cluster and alopecia.";
RL Development 128:1547-1558(2001).
RN [2] {ECO:0000312|EMBL:BAC25027.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC25027.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAC25027.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000312|EMBL:AAI32613.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP TISSUE SPECIFICITY.
RX PubMed=15385554; DOI=10.1074/jbc.m404331200;
RA Pruett N.D., Tkatchenko T.V., Jave-Suarez L., Jacobs D.F., Potter C.S.,
RA Tkatchenko A.V., Schweizer J., Awgulewitsch A.;
RT "Krtap16, characterization of a new hair keratin-associated protein (KAP)
RT gene complex on mouse chromosome 16 and evidence for regulation by
RT Hoxc13.";
RL J. Biol. Chem. 279:51524-51533(2004).
RN [5] {ECO:0000305}
RP INDUCTION.
RX PubMed=17151017; DOI=10.1242/dev.02721;
RA Kurek D., Garinis G.A., van Doorninck J.H., van der Wees J., Grosveld F.G.;
RT "Transcriptome and phenotypic analysis reveals Gata3-dependent signalling
RT pathways in murine hair follicles.";
RL Development 134:261-272(2007).
CC -!- FUNCTION: In the hair cortex, hair keratin intermediate filaments are
CC embedded in an interfilamentous matrix, consisting of hair keratin-
CC associated proteins (KRTAP), which are essential for the formation of a
CC rigid and resistant hair shaft through their extensive disulfide bond
CC cross-linking with abundant cysteine residues of hair keratins. The
CC matrix proteins include the high-sulfur and high-glycine-tyrosine
CC keratins. {ECO:0000305}.
CC -!- SUBUNIT: Interacts with hair keratins. {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strong expression in narrowly defined pattern
CC restricted to the lower and middle cortical regions of the hair shaft
CC in both developing and cycling hair. During hair follicle regression
CC (catagen), expression levels decrease until expression is no longer
CC detectable in follicles at resting stage (telogen).
CC {ECO:0000269|PubMed:15385554, ECO:0000269|PubMed:15489334}.
CC -!- INDUCTION: Expression in skin and hair follicle is regulated by HOXC13
CC and by GATA3. {ECO:0000269|PubMed:11290294,
CC ECO:0000269|PubMed:17151017}.
CC -!- SIMILARITY: Belongs to the KRTAP type 6 family. {ECO:0000305}.
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DR EMBL; AF345298; AAK52896.1; -; mRNA.
DR EMBL; AK003281; BAC25027.1; -; mRNA.
DR EMBL; BC132612; AAI32613.1; -; mRNA.
DR CCDS; CCDS37390.1; -.
DR RefSeq; NP_570926.1; NM_130856.2.
DR AlphaFoldDB; Q925H3; -.
DR STRING; 10090.ENSMUSP00000074211; -.
DR PaxDb; Q925H3; -.
DR PRIDE; Q925H3; -.
DR Ensembl; ENSMUST00000074637; ENSMUSP00000074211; ENSMUSG00000062400.
DR GeneID; 68484; -.
DR KEGG; mmu:68484; -.
DR UCSC; uc012ahz.1; mouse.
DR CTD; 68484; -.
DR MGI; MGI:1915734; Krtap6-5.
DR VEuPathDB; HostDB:ENSMUSG00000062400; -.
DR GeneTree; ENSGT00920000149427; -.
DR HOGENOM; CLU_182642_0_0_1; -.
DR OMA; YRSCYGS; -.
DR Reactome; R-MMU-6805567; Keratinization.
DR BioGRID-ORCS; 68484; 6 hits in 37 CRISPR screens.
DR ChiTaRS; Krtap6-5; mouse.
DR PRO; PR:Q925H3; -.
DR Proteomes; UP000000589; Chromosome 16.
DR RNAct; Q925H3; protein.
DR Bgee; ENSMUSG00000062400; Expressed in tail skin and 13 other tissues.
DR Genevisible; Q925H3; MM.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0031424; P:keratinization; IEA:InterPro.
DR InterPro; IPR040313; KAP6.
DR PANTHER; PTHR31678; PTHR31678; 1.
PE 2: Evidence at transcript level;
KW Keratin; Reference proteome; Repeat.
FT CHAIN 1..78
FT /note="Keratin-associated protein 6-5"
FT /id="PRO_0000356217"
FT REGION 3..76
FT /note="25 X 2 AA repeats of G-[YCGS]"
FT /evidence="ECO:0000255"
SQ SEQUENCE 78 AA; 7945 MW; 41991950D5F9D8E6 CRC64;
MCGYYGNYYG GRGYGCCGCG GLGYGYGGLG CGYGSYYGCG YRGLGCGYGY GCGYGSRSLY
GCGYGCGSGY GSGFGYYY
